PMID- 25116577
OWN - NLM
STAT- MEDLINE
DCOM- 20150224
LR  - 20141003
IS  - 1421-9751 (Electronic)
IS  - 0008-6312 (Linking)
VI  - 129
IP  - 2
DP  - 2014
TI  - Intracoronary injection of CD34-cells in chronic ischemic heart failure: 7 years 
      follow-up of the DanCell study.
PG  - 69-74
LID - 10.1159/000363133 [doi]
AB  - OBJECTIVES: Seven years ago, the DanCell study was carried out to test the 
      hypothesis of improvement in left ventricular ejection fraction (LVEF) following 
      repeated intracoronary injections of autologous bone marrow-derived stem cells 
      (BMSCs) in patients suffering from chronic ischemic heart failure. In this post 
      hoc analysis, the long-term effect of therapy is assessed. METHODS: 32 patients 
      [mean age 61 (SD +/- 9), 81% males] with systolic dysfunction (LVEF 33 +/- 9%) 
      received two repeated intracoronary infusions (4 months apart) of autologous 
      BMSCs (1,533 +/- 765 x 10(6) BMSCs including 23 +/- 11 x 10(6) CD34(+) cells and 14 +/- 
      7 x 10(6) CD133(+) cells). Patients were followed for 7 years and deaths were 
      recorded. RESULTS: During follow-up, 10 patients died (31%). In univariate 
      regression analysis, the total number of BMSCs, CD34(+) cell count and CD133(+) 
      cell count did not significantly correlate with survival (hazard ratio: 0.999, 
      95% CI: 0.998-1.000, p = 0.24; hazard ratio: 0.94, 95% CI: 0.88-1.01, p = 0.10, 
      and hazard ratio: 0.96, 95% CI: 0.87-1.07, p = 0.47, respectively). After 
      adjustment for baseline variables in multivariate regression analysis, the 
      CD34(+) cell count was significantly associated with survival (hazard ratio: 
      0.90, 95% CI: 0.82-1.00, p = 0.04). CONCLUSIONS: Intracoronary injections of a 
      high number of CD34(+) cells may have a beneficial effect on chronic ischemic 
      heart failure in terms of long-term survival.
FAU - Hansen, Morten
AU  - Hansen M
AD  - Department of Cardiology, Odense University Hospital, Odense, Denmark.
FAU - Nyby, Sebastian
AU  - Nyby S
FAU - Eifer Moller, Jacob
AU  - Eifer Moller J
FAU - Videbaek, Lars
AU  - Videbaek L
FAU - Kassem, Moustapha
AU  - Kassem M
FAU - Barington, Torben
AU  - Barington T
FAU - Thayssen, Per
AU  - Thayssen P
FAU - Diederichsen, Axel Cosmus Pyndt
AU  - Diederichsen AC
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20140812
PL  - Switzerland
TA  - Cardiology
JT  - Cardiology
JID - 1266406
RN  - 0 (Antigens, CD34)
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - Aged
MH  - *Antigens, CD34
MH  - Bone Marrow Transplantation/methods
MH  - Chronic Disease
MH  - Female
MH  - Follow-Up Studies
MH  - Heart Failure/*therapy
MH  - Humans
MH  - Infusions, Intralesional
MH  - Injections, Intralesional
MH  - Male
MH  - Middle Aged
MH  - Myocardial Ischemia/therapy
MH  - Stem Cell Transplantation/*methods
MH  - Transplantation, Autologous/methods
MH  - Treatment Outcome
MH  - Ventricular Dysfunction, Left/therapy
MH  - Young Adult
EDAT- 2014/08/15 06:00
MHDA- 2015/02/25 06:00
CRDT- 2014/08/14 06:00
PHST- 2014/01/27 00:00 [received]
PHST- 2014/04/24 00:00 [accepted]
PHST- 2014/08/14 06:00 [entrez]
PHST- 2014/08/15 06:00 [pubmed]
PHST- 2015/02/25 06:00 [medline]
AID - 000363133 [pii]
AID - 10.1159/000363133 [doi]
PST - ppublish
SO  - Cardiology. 2014;129(2):69-74. doi: 10.1159/000363133. Epub 2014 Aug 12.