PMID- 25117065
OWN - NLM
STAT- MEDLINE
DCOM- 20150514
LR  - 20211021
IS  - 1549-490X (Electronic)
IS  - 1083-7159 (Print)
IS  - 1083-7159 (Linking)
VI  - 19
IP  - 9
DP  - 2014 Sep
TI  - Real-world study of everolimus in advanced progressive neuroendocrine tumors.
PG  - 966-74
LID - 10.1634/theoncologist.2014-0037 [doi]
AB  - Everolimus is a valid therapeutic option for neuroendocrine tumors (NETs); 
      however, data in a real-world setting outside regulatory trials are sparse. The 
      aim of this study was to determine everolimus tolerability and efficacy, in 
      relation to previous treatments, in a compassionate use program. A total of 169 
      patients with advanced progressive NETs treated with everolimus were enrolled, 
      including 85 with pancreatic NETs (pNETs) and 84 with nonpancreatic NETs 
      (non-pNETs). Previous treatments included somatostatin analogs (92.9%), peptide 
      receptor radionuclide therapy (PRRT; 50.3%), chemotherapy (49.7%), and PRRT and 
      chemotherapy (22.8%). Overall, 85.2% of patients experienced adverse events 
      (AEs), which were severe (grade 3-4) in 46.1%. The most frequent severe AEs were 
      pneumonitis (8.3%), thrombocytopenia (7.7%), anemia (5.3%), and renal failure 
      (3.5%). In patients previously treated with PRRT and chemotherapy, a 12-fold 
      increased risk for severe toxicity was observed, with grade 3-4 AEs reported in 
      86.8% (vs. 34.3% in other patients). In addition, 63.3% of patients required 
      temporarily everolimus discontinuation due to toxicity. Overall, 27.8% of 
      patients died during a median follow-up of 12 months. Median progression-free 
      survival (PFS) and overall survival (OS) were 12 months and 32 months, 
      respectively. Similar disease control rates, PFS, and OS were reported in pNETs 
      and non-pNETs. In the real-world setting, everolimus is safe and effective for 
      the treatment of NETs of different origins. Higher severe toxicity occurred in 
      patients previously treated with systemic chemotherapy and PRRT. This finding 
      prompts caution when using this drug in pretreated patients and raises the issue 
      of planning for everolimus before PRRT and chemotherapy in the therapeutic 
      algorithm for advanced NETs.
CI  - (c)AlphaMed Press.
FAU - Panzuto, Francesco
AU  - Panzuto F
AD  - Digestive and Liver Disease, Sapienza University of Rome, Sant'Andrea Hospital, 
      Rome, Italy; Unit of Gastrointestinal and Neuroendocrine Tumors, European 
      Institute of Oncology, Milan, Italy; Department of Medical Oncology, Fondazione 
      IRCCS Istituto Nazionale Tumori, Milan, Italy; Oncology and Hematology, 
      Policlinico di Modena, Italy; Section of Endocrinology and Internal Medicine, 
      Department of Medical Sciences, University of Ferrara, Ferrara, Italy; 
      Departments of Endocrinology and Oncologia Medica, Universita Cattolica del S. 
      Cuore, Rome, Italy; Departments of Medical and Surgical Sciences and Medical 
      Oncology, S. Orsola-Malpighi Hospital, University of Bologna, Bologna, Italy; 
      Oncology, Antonio Cardarelli Hospital, Naples, Italy; Division of Medical 
      Oncology and Endocrinology Unit, Regina Elena National Cancer Institute Rome, 
      IRCCS, Rome, Italy; Oncology, San Luigi Gonzaga Hospital, Orbassano, Torino, 
      Italy; Department of Clinical Medicine and Surgery, Federico II University of 
      Naples, Naples, Italy; Oncology, Fondazione Poliambulanza, Brescia, Italy; 
      Oncology, Istituto Oncologico Veneto, Padova, Italy; Departments of Medical 
      Oncology and Pancreatic Surgery, AOU Ospedali Riuniti, Universita Politecnica 
      delle Marche, Ancona, Italy; Oncology, S. Croce e Carle Hospital, Cuneo, Italy; 
      Department of Medical Oncology A, IRCCS AOU San Martino-IST, Genova, Italy; 
      Oncologia Medica 1, Azienda Ospedaliero-Universitaria Careggi, Florence, Italy; 
      Oncology, Niguarda Cancer Center, Ospedale Niguarda Ca' Granda, Milan, Italy; 
      Oncologia, Spedali Civili di Brescia, University of Brescia, Brescia, Italy.
FAU - Rinzivillo, Maria
AU  - Rinzivillo M
AD  - Digestive and Liver Disease, Sapienza University of Rome, Sant'Andrea Hospital, 
      Rome, Italy; Unit of Gastrointestinal and Neuroendocrine Tumors, European 
      Institute of Oncology, Milan, Italy; Department of Medical Oncology, Fondazione 
      IRCCS Istituto Nazionale Tumori, Milan, Italy; Oncology and Hematology, 
      Policlinico di Modena, Italy; Section of Endocrinology and Internal Medicine, 
      Department of Medical Sciences, University of Ferrara, Ferrara, Italy; 
      Departments of Endocrinology and Oncologia Medica, Universita Cattolica del S. 
      Cuore, Rome, Italy; Departments of Medical and Surgical Sciences and Medical 
      Oncology, S. Orsola-Malpighi Hospital, University of Bologna, Bologna, Italy; 
      Oncology, Antonio Cardarelli Hospital, Naples, Italy; Division of Medical 
      Oncology and Endocrinology Unit, Regina Elena National Cancer Institute Rome, 
      IRCCS, Rome, Italy; Oncology, San Luigi Gonzaga Hospital, Orbassano, Torino, 
      Italy; Department of Clinical Medicine and Surgery, Federico II University of 
      Naples, Naples, Italy; Oncology, Fondazione Poliambulanza, Brescia, Italy; 
      Oncology, Istituto Oncologico Veneto, Padova, Italy; Departments of Medical 
      Oncology and Pancreatic Surgery, AOU Ospedali Riuniti, Universita Politecnica 
      delle Marche, Ancona, Italy; Oncology, S. Croce e Carle Hospital, Cuneo, Italy; 
      Department of Medical Oncology A, IRCCS AOU San Martino-IST, Genova, Italy; 
      Oncologia Medica 1, Azienda Ospedaliero-Universitaria Careggi, Florence, Italy; 
      Oncology, Niguarda Cancer Center, Ospedale Niguarda Ca' Granda, Milan, Italy; 
      Oncologia, Spedali Civili di Brescia, University of Brescia, Brescia, Italy.
FAU - Fazio, Nicola
AU  - Fazio N
AD  - Digestive and Liver Disease, Sapienza University of Rome, Sant'Andrea Hospital, 
      Rome, Italy; Unit of Gastrointestinal and Neuroendocrine Tumors, European 
      Institute of Oncology, Milan, Italy; Department of Medical Oncology, Fondazione 
      IRCCS Istituto Nazionale Tumori, Milan, Italy; Oncology and Hematology, 
      Policlinico di Modena, Italy; Section of Endocrinology and Internal Medicine, 
      Department of Medical Sciences, University of Ferrara, Ferrara, Italy; 
      Departments of Endocrinology and Oncologia Medica, Universita Cattolica del S. 
      Cuore, Rome, Italy; Departments of Medical and Surgical Sciences and Medical 
      Oncology, S. Orsola-Malpighi Hospital, University of Bologna, Bologna, Italy; 
      Oncology, Antonio Cardarelli Hospital, Naples, Italy; Division of Medical 
      Oncology and Endocrinology Unit, Regina Elena National Cancer Institute Rome, 
      IRCCS, Rome, Italy; Oncology, San Luigi Gonzaga Hospital, Orbassano, Torino, 
      Italy; Department of Clinical Medicine and Surgery, Federico II University of 
      Naples, Naples, Italy; Oncology, Fondazione Poliambulanza, Brescia, Italy; 
      Oncology, Istituto Oncologico Veneto, Padova, Italy; Departments of Medical 
      Oncology and Pancreatic Surgery, AOU Ospedali Riuniti, Universita Politecnica 
      delle Marche, Ancona, Italy; Oncology, S. Croce e Carle Hospital, Cuneo, Italy; 
      Department of Medical Oncology A, IRCCS AOU San Martino-IST, Genova, Italy; 
      Oncologia Medica 1, Azienda Ospedaliero-Universitaria Careggi, Florence, Italy; 
      Oncology, Niguarda Cancer Center, Ospedale Niguarda Ca' Granda, Milan, Italy; 
      Oncologia, Spedali Civili di Brescia, University of Brescia, Brescia, Italy.
FAU - de Braud, Filippo
AU  - de Braud F
AD  - Digestive and Liver Disease, Sapienza University of Rome, Sant'Andrea Hospital, 
      Rome, Italy; Unit of Gastrointestinal and Neuroendocrine Tumors, European 
      Institute of Oncology, Milan, Italy; Department of Medical Oncology, Fondazione 
      IRCCS Istituto Nazionale Tumori, Milan, Italy; Oncology and Hematology, 
      Policlinico di Modena, Italy; Section of Endocrinology and Internal Medicine, 
      Department of Medical Sciences, University of Ferrara, Ferrara, Italy; 
      Departments of Endocrinology and Oncologia Medica, Universita Cattolica del S. 
      Cuore, Rome, Italy; Departments of Medical and Surgical Sciences and Medical 
      Oncology, S. Orsola-Malpighi Hospital, University of Bologna, Bologna, Italy; 
      Oncology, Antonio Cardarelli Hospital, Naples, Italy; Division of Medical 
      Oncology and Endocrinology Unit, Regina Elena National Cancer Institute Rome, 
      IRCCS, Rome, Italy; Oncology, San Luigi Gonzaga Hospital, Orbassano, Torino, 
      Italy; Department of Clinical Medicine and Surgery, Federico II University of 
      Naples, Naples, Italy; Oncology, Fondazione Poliambulanza, Brescia, Italy; 
      Oncology, Istituto Oncologico Veneto, Padova, Italy; Departments of Medical 
      Oncology and Pancreatic Surgery, AOU Ospedali Riuniti, Universita Politecnica 
      delle Marche, Ancona, Italy; Oncology, S. Croce e Carle Hospital, Cuneo, Italy; 
      Department of Medical Oncology A, IRCCS AOU San Martino-IST, Genova, Italy; 
      Oncologia Medica 1, Azienda Ospedaliero-Universitaria Careggi, Florence, Italy; 
      Oncology, Niguarda Cancer Center, Ospedale Niguarda Ca' Granda, Milan, Italy; 
      Oncologia, Spedali Civili di Brescia, University of Brescia, Brescia, Italy.
FAU - Luppi, Gabriele
AU  - Luppi G
AD  - Digestive and Liver Disease, Sapienza University of Rome, Sant'Andrea Hospital, 
      Rome, Italy; Unit of Gastrointestinal and Neuroendocrine Tumors, European 
      Institute of Oncology, Milan, Italy; Department of Medical Oncology, Fondazione 
      IRCCS Istituto Nazionale Tumori, Milan, Italy; Oncology and Hematology, 
      Policlinico di Modena, Italy; Section of Endocrinology and Internal Medicine, 
      Department of Medical Sciences, University of Ferrara, Ferrara, Italy; 
      Departments of Endocrinology and Oncologia Medica, Universita Cattolica del S. 
      Cuore, Rome, Italy; Departments of Medical and Surgical Sciences and Medical 
      Oncology, S. Orsola-Malpighi Hospital, University of Bologna, Bologna, Italy; 
      Oncology, Antonio Cardarelli Hospital, Naples, Italy; Division of Medical 
      Oncology and Endocrinology Unit, Regina Elena National Cancer Institute Rome, 
      IRCCS, Rome, Italy; Oncology, San Luigi Gonzaga Hospital, Orbassano, Torino, 
      Italy; Department of Clinical Medicine and Surgery, Federico II University of 
      Naples, Naples, Italy; Oncology, Fondazione Poliambulanza, Brescia, Italy; 
      Oncology, Istituto Oncologico Veneto, Padova, Italy; Departments of Medical 
      Oncology and Pancreatic Surgery, AOU Ospedali Riuniti, Universita Politecnica 
      delle Marche, Ancona, Italy; Oncology, S. Croce e Carle Hospital, Cuneo, Italy; 
      Department of Medical Oncology A, IRCCS AOU San Martino-IST, Genova, Italy; 
      Oncologia Medica 1, Azienda Ospedaliero-Universitaria Careggi, Florence, Italy; 
      Oncology, Niguarda Cancer Center, Ospedale Niguarda Ca' Granda, Milan, Italy; 
      Oncologia, Spedali Civili di Brescia, University of Brescia, Brescia, Italy.
FAU - Zatelli, Maria Chiara
AU  - Zatelli MC
AD  - Digestive and Liver Disease, Sapienza University of Rome, Sant'Andrea Hospital, 
      Rome, Italy; Unit of Gastrointestinal and Neuroendocrine Tumors, European 
      Institute of Oncology, Milan, Italy; Department of Medical Oncology, Fondazione 
      IRCCS Istituto Nazionale Tumori, Milan, Italy; Oncology and Hematology, 
      Policlinico di Modena, Italy; Section of Endocrinology and Internal Medicine, 
      Department of Medical Sciences, University of Ferrara, Ferrara, Italy; 
      Departments of Endocrinology and Oncologia Medica, Universita Cattolica del S. 
      Cuore, Rome, Italy; Departments of Medical and Surgical Sciences and Medical 
      Oncology, S. Orsola-Malpighi Hospital, University of Bologna, Bologna, Italy; 
      Oncology, Antonio Cardarelli Hospital, Naples, Italy; Division of Medical 
      Oncology and Endocrinology Unit, Regina Elena National Cancer Institute Rome, 
      IRCCS, Rome, Italy; Oncology, San Luigi Gonzaga Hospital, Orbassano, Torino, 
      Italy; Department of Clinical Medicine and Surgery, Federico II University of 
      Naples, Naples, Italy; Oncology, Fondazione Poliambulanza, Brescia, Italy; 
      Oncology, Istituto Oncologico Veneto, Padova, Italy; Departments of Medical 
      Oncology and Pancreatic Surgery, AOU Ospedali Riuniti, Universita Politecnica 
      delle Marche, Ancona, Italy; Oncology, S. Croce e Carle Hospital, Cuneo, Italy; 
      Department of Medical Oncology A, IRCCS AOU San Martino-IST, Genova, Italy; 
      Oncologia Medica 1, Azienda Ospedaliero-Universitaria Careggi, Florence, Italy; 
      Oncology, Niguarda Cancer Center, Ospedale Niguarda Ca' Granda, Milan, Italy; 
      Oncologia, Spedali Civili di Brescia, University of Brescia, Brescia, Italy.
FAU - Lugli, Francesca
AU  - Lugli F
AD  - Digestive and Liver Disease, Sapienza University of Rome, Sant'Andrea Hospital, 
      Rome, Italy; Unit of Gastrointestinal and Neuroendocrine Tumors, European 
      Institute of Oncology, Milan, Italy; Department of Medical Oncology, Fondazione 
      IRCCS Istituto Nazionale Tumori, Milan, Italy; Oncology and Hematology, 
      Policlinico di Modena, Italy; Section of Endocrinology and Internal Medicine, 
      Department of Medical Sciences, University of Ferrara, Ferrara, Italy; 
      Departments of Endocrinology and Oncologia Medica, Universita Cattolica del S. 
      Cuore, Rome, Italy; Departments of Medical and Surgical Sciences and Medical 
      Oncology, S. Orsola-Malpighi Hospital, University of Bologna, Bologna, Italy; 
      Oncology, Antonio Cardarelli Hospital, Naples, Italy; Division of Medical 
      Oncology and Endocrinology Unit, Regina Elena National Cancer Institute Rome, 
      IRCCS, Rome, Italy; Oncology, San Luigi Gonzaga Hospital, Orbassano, Torino, 
      Italy; Department of Clinical Medicine and Surgery, Federico II University of 
      Naples, Naples, Italy; Oncology, Fondazione Poliambulanza, Brescia, Italy; 
      Oncology, Istituto Oncologico Veneto, Padova, Italy; Departments of Medical 
      Oncology and Pancreatic Surgery, AOU Ospedali Riuniti, Universita Politecnica 
      delle Marche, Ancona, Italy; Oncology, S. Croce e Carle Hospital, Cuneo, Italy; 
      Department of Medical Oncology A, IRCCS AOU San Martino-IST, Genova, Italy; 
      Oncologia Medica 1, Azienda Ospedaliero-Universitaria Careggi, Florence, Italy; 
      Oncology, Niguarda Cancer Center, Ospedale Niguarda Ca' Granda, Milan, Italy; 
      Oncologia, Spedali Civili di Brescia, University of Brescia, Brescia, Italy.
FAU - Tomassetti, Paola
AU  - Tomassetti P
AD  - Digestive and Liver Disease, Sapienza University of Rome, Sant'Andrea Hospital, 
      Rome, Italy; Unit of Gastrointestinal and Neuroendocrine Tumors, European 
      Institute of Oncology, Milan, Italy; Department of Medical Oncology, Fondazione 
      IRCCS Istituto Nazionale Tumori, Milan, Italy; Oncology and Hematology, 
      Policlinico di Modena, Italy; Section of Endocrinology and Internal Medicine, 
      Department of Medical Sciences, University of Ferrara, Ferrara, Italy; 
      Departments of Endocrinology and Oncologia Medica, Universita Cattolica del S. 
      Cuore, Rome, Italy; Departments of Medical and Surgical Sciences and Medical 
      Oncology, S. Orsola-Malpighi Hospital, University of Bologna, Bologna, Italy; 
      Oncology, Antonio Cardarelli Hospital, Naples, Italy; Division of Medical 
      Oncology and Endocrinology Unit, Regina Elena National Cancer Institute Rome, 
      IRCCS, Rome, Italy; Oncology, San Luigi Gonzaga Hospital, Orbassano, Torino, 
      Italy; Department of Clinical Medicine and Surgery, Federico II University of 
      Naples, Naples, Italy; Oncology, Fondazione Poliambulanza, Brescia, Italy; 
      Oncology, Istituto Oncologico Veneto, Padova, Italy; Departments of Medical 
      Oncology and Pancreatic Surgery, AOU Ospedali Riuniti, Universita Politecnica 
      delle Marche, Ancona, Italy; Oncology, S. Croce e Carle Hospital, Cuneo, Italy; 
      Department of Medical Oncology A, IRCCS AOU San Martino-IST, Genova, Italy; 
      Oncologia Medica 1, Azienda Ospedaliero-Universitaria Careggi, Florence, Italy; 
      Oncology, Niguarda Cancer Center, Ospedale Niguarda Ca' Granda, Milan, Italy; 
      Oncologia, Spedali Civili di Brescia, University of Brescia, Brescia, Italy.
FAU - Riccardi, Ferdinando
AU  - Riccardi F
AD  - Digestive and Liver Disease, Sapienza University of Rome, Sant'Andrea Hospital, 
      Rome, Italy; Unit of Gastrointestinal and Neuroendocrine Tumors, European 
      Institute of Oncology, Milan, Italy; Department of Medical Oncology, Fondazione 
      IRCCS Istituto Nazionale Tumori, Milan, Italy; Oncology and Hematology, 
      Policlinico di Modena, Italy; Section of Endocrinology and Internal Medicine, 
      Department of Medical Sciences, University of Ferrara, Ferrara, Italy; 
      Departments of Endocrinology and Oncologia Medica, Universita Cattolica del S. 
      Cuore, Rome, Italy; Departments of Medical and Surgical Sciences and Medical 
      Oncology, S. Orsola-Malpighi Hospital, University of Bologna, Bologna, Italy; 
      Oncology, Antonio Cardarelli Hospital, Naples, Italy; Division of Medical 
      Oncology and Endocrinology Unit, Regina Elena National Cancer Institute Rome, 
      IRCCS, Rome, Italy; Oncology, San Luigi Gonzaga Hospital, Orbassano, Torino, 
      Italy; Department of Clinical Medicine and Surgery, Federico II University of 
      Naples, Naples, Italy; Oncology, Fondazione Poliambulanza, Brescia, Italy; 
      Oncology, Istituto Oncologico Veneto, Padova, Italy; Departments of Medical 
      Oncology and Pancreatic Surgery, AOU Ospedali Riuniti, Universita Politecnica 
      delle Marche, Ancona, Italy; Oncology, S. Croce e Carle Hospital, Cuneo, Italy; 
      Department of Medical Oncology A, IRCCS AOU San Martino-IST, Genova, Italy; 
      Oncologia Medica 1, Azienda Ospedaliero-Universitaria Careggi, Florence, Italy; 
      Oncology, Niguarda Cancer Center, Ospedale Niguarda Ca' Granda, Milan, Italy; 
      Oncologia, Spedali Civili di Brescia, University of Brescia, Brescia, Italy.
FAU - Nuzzo, Carmen
AU  - Nuzzo C
AD  - Digestive and Liver Disease, Sapienza University of Rome, Sant'Andrea Hospital, 
      Rome, Italy; Unit of Gastrointestinal and Neuroendocrine Tumors, European 
      Institute of Oncology, Milan, Italy; Department of Medical Oncology, Fondazione 
      IRCCS Istituto Nazionale Tumori, Milan, Italy; Oncology and Hematology, 
      Policlinico di Modena, Italy; Section of Endocrinology and Internal Medicine, 
      Department of Medical Sciences, University of Ferrara, Ferrara, Italy; 
      Departments of Endocrinology and Oncologia Medica, Universita Cattolica del S. 
      Cuore, Rome, Italy; Departments of Medical and Surgical Sciences and Medical 
      Oncology, S. Orsola-Malpighi Hospital, University of Bologna, Bologna, Italy; 
      Oncology, Antonio Cardarelli Hospital, Naples, Italy; Division of Medical 
      Oncology and Endocrinology Unit, Regina Elena National Cancer Institute Rome, 
      IRCCS, Rome, Italy; Oncology, San Luigi Gonzaga Hospital, Orbassano, Torino, 
      Italy; Department of Clinical Medicine and Surgery, Federico II University of 
      Naples, Naples, Italy; Oncology, Fondazione Poliambulanza, Brescia, Italy; 
      Oncology, Istituto Oncologico Veneto, Padova, Italy; Departments of Medical 
      Oncology and Pancreatic Surgery, AOU Ospedali Riuniti, Universita Politecnica 
      delle Marche, Ancona, Italy; Oncology, S. Croce e Carle Hospital, Cuneo, Italy; 
      Department of Medical Oncology A, IRCCS AOU San Martino-IST, Genova, Italy; 
      Oncologia Medica 1, Azienda Ospedaliero-Universitaria Careggi, Florence, Italy; 
      Oncology, Niguarda Cancer Center, Ospedale Niguarda Ca' Granda, Milan, Italy; 
      Oncologia, Spedali Civili di Brescia, University of Brescia, Brescia, Italy.
FAU - Brizzi, Maria Pia
AU  - Brizzi MP
AD  - Digestive and Liver Disease, Sapienza University of Rome, Sant'Andrea Hospital, 
      Rome, Italy; Unit of Gastrointestinal and Neuroendocrine Tumors, European 
      Institute of Oncology, Milan, Italy; Department of Medical Oncology, Fondazione 
      IRCCS Istituto Nazionale Tumori, Milan, Italy; Oncology and Hematology, 
      Policlinico di Modena, Italy; Section of Endocrinology and Internal Medicine, 
      Department of Medical Sciences, University of Ferrara, Ferrara, Italy; 
      Departments of Endocrinology and Oncologia Medica, Universita Cattolica del S. 
      Cuore, Rome, Italy; Departments of Medical and Surgical Sciences and Medical 
      Oncology, S. Orsola-Malpighi Hospital, University of Bologna, Bologna, Italy; 
      Oncology, Antonio Cardarelli Hospital, Naples, Italy; Division of Medical 
      Oncology and Endocrinology Unit, Regina Elena National Cancer Institute Rome, 
      IRCCS, Rome, Italy; Oncology, San Luigi Gonzaga Hospital, Orbassano, Torino, 
      Italy; Department of Clinical Medicine and Surgery, Federico II University of 
      Naples, Naples, Italy; Oncology, Fondazione Poliambulanza, Brescia, Italy; 
      Oncology, Istituto Oncologico Veneto, Padova, Italy; Departments of Medical 
      Oncology and Pancreatic Surgery, AOU Ospedali Riuniti, Universita Politecnica 
      delle Marche, Ancona, Italy; Oncology, S. Croce e Carle Hospital, Cuneo, Italy; 
      Department of Medical Oncology A, IRCCS AOU San Martino-IST, Genova, Italy; 
      Oncologia Medica 1, Azienda Ospedaliero-Universitaria Careggi, Florence, Italy; 
      Oncology, Niguarda Cancer Center, Ospedale Niguarda Ca' Granda, Milan, Italy; 
      Oncologia, Spedali Civili di Brescia, University of Brescia, Brescia, Italy.
FAU - Faggiano, Antongiulio
AU  - Faggiano A
AD  - Digestive and Liver Disease, Sapienza University of Rome, Sant'Andrea Hospital, 
      Rome, Italy; Unit of Gastrointestinal and Neuroendocrine Tumors, European 
      Institute of Oncology, Milan, Italy; Department of Medical Oncology, Fondazione 
      IRCCS Istituto Nazionale Tumori, Milan, Italy; Oncology and Hematology, 
      Policlinico di Modena, Italy; Section of Endocrinology and Internal Medicine, 
      Department of Medical Sciences, University of Ferrara, Ferrara, Italy; 
      Departments of Endocrinology and Oncologia Medica, Universita Cattolica del S. 
      Cuore, Rome, Italy; Departments of Medical and Surgical Sciences and Medical 
      Oncology, S. Orsola-Malpighi Hospital, University of Bologna, Bologna, Italy; 
      Oncology, Antonio Cardarelli Hospital, Naples, Italy; Division of Medical 
      Oncology and Endocrinology Unit, Regina Elena National Cancer Institute Rome, 
      IRCCS, Rome, Italy; Oncology, San Luigi Gonzaga Hospital, Orbassano, Torino, 
      Italy; Department of Clinical Medicine and Surgery, Federico II University of 
      Naples, Naples, Italy; Oncology, Fondazione Poliambulanza, Brescia, Italy; 
      Oncology, Istituto Oncologico Veneto, Padova, Italy; Departments of Medical 
      Oncology and Pancreatic Surgery, AOU Ospedali Riuniti, Universita Politecnica 
      delle Marche, Ancona, Italy; Oncology, S. Croce e Carle Hospital, Cuneo, Italy; 
      Department of Medical Oncology A, IRCCS AOU San Martino-IST, Genova, Italy; 
      Oncologia Medica 1, Azienda Ospedaliero-Universitaria Careggi, Florence, Italy; 
      Oncology, Niguarda Cancer Center, Ospedale Niguarda Ca' Granda, Milan, Italy; 
      Oncologia, Spedali Civili di Brescia, University of Brescia, Brescia, Italy.
FAU - Zaniboni, Alberto
AU  - Zaniboni A
AD  - Digestive and Liver Disease, Sapienza University of Rome, Sant'Andrea Hospital, 
      Rome, Italy; Unit of Gastrointestinal and Neuroendocrine Tumors, European 
      Institute of Oncology, Milan, Italy; Department of Medical Oncology, Fondazione 
      IRCCS Istituto Nazionale Tumori, Milan, Italy; Oncology and Hematology, 
      Policlinico di Modena, Italy; Section of Endocrinology and Internal Medicine, 
      Department of Medical Sciences, University of Ferrara, Ferrara, Italy; 
      Departments of Endocrinology and Oncologia Medica, Universita Cattolica del S. 
      Cuore, Rome, Italy; Departments of Medical and Surgical Sciences and Medical 
      Oncology, S. Orsola-Malpighi Hospital, University of Bologna, Bologna, Italy; 
      Oncology, Antonio Cardarelli Hospital, Naples, Italy; Division of Medical 
      Oncology and Endocrinology Unit, Regina Elena National Cancer Institute Rome, 
      IRCCS, Rome, Italy; Oncology, San Luigi Gonzaga Hospital, Orbassano, Torino, 
      Italy; Department of Clinical Medicine and Surgery, Federico II University of 
      Naples, Naples, Italy; Oncology, Fondazione Poliambulanza, Brescia, Italy; 
      Oncology, Istituto Oncologico Veneto, Padova, Italy; Departments of Medical 
      Oncology and Pancreatic Surgery, AOU Ospedali Riuniti, Universita Politecnica 
      delle Marche, Ancona, Italy; Oncology, S. Croce e Carle Hospital, Cuneo, Italy; 
      Department of Medical Oncology A, IRCCS AOU San Martino-IST, Genova, Italy; 
      Oncologia Medica 1, Azienda Ospedaliero-Universitaria Careggi, Florence, Italy; 
      Oncology, Niguarda Cancer Center, Ospedale Niguarda Ca' Granda, Milan, Italy; 
      Oncologia, Spedali Civili di Brescia, University of Brescia, Brescia, Italy.
FAU - Nobili, Elisabetta
AU  - Nobili E
AD  - Digestive and Liver Disease, Sapienza University of Rome, Sant'Andrea Hospital, 
      Rome, Italy; Unit of Gastrointestinal and Neuroendocrine Tumors, European 
      Institute of Oncology, Milan, Italy; Department of Medical Oncology, Fondazione 
      IRCCS Istituto Nazionale Tumori, Milan, Italy; Oncology and Hematology, 
      Policlinico di Modena, Italy; Section of Endocrinology and Internal Medicine, 
      Department of Medical Sciences, University of Ferrara, Ferrara, Italy; 
      Departments of Endocrinology and Oncologia Medica, Universita Cattolica del S. 
      Cuore, Rome, Italy; Departments of Medical and Surgical Sciences and Medical 
      Oncology, S. Orsola-Malpighi Hospital, University of Bologna, Bologna, Italy; 
      Oncology, Antonio Cardarelli Hospital, Naples, Italy; Division of Medical 
      Oncology and Endocrinology Unit, Regina Elena National Cancer Institute Rome, 
      IRCCS, Rome, Italy; Oncology, San Luigi Gonzaga Hospital, Orbassano, Torino, 
      Italy; Department of Clinical Medicine and Surgery, Federico II University of 
      Naples, Naples, Italy; Oncology, Fondazione Poliambulanza, Brescia, Italy; 
      Oncology, Istituto Oncologico Veneto, Padova, Italy; Departments of Medical 
      Oncology and Pancreatic Surgery, AOU Ospedali Riuniti, Universita Politecnica 
      delle Marche, Ancona, Italy; Oncology, S. Croce e Carle Hospital, Cuneo, Italy; 
      Department of Medical Oncology A, IRCCS AOU San Martino-IST, Genova, Italy; 
      Oncologia Medica 1, Azienda Ospedaliero-Universitaria Careggi, Florence, Italy; 
      Oncology, Niguarda Cancer Center, Ospedale Niguarda Ca' Granda, Milan, Italy; 
      Oncologia, Spedali Civili di Brescia, University of Brescia, Brescia, Italy.
FAU - Pastorelli, Davide
AU  - Pastorelli D
AD  - Digestive and Liver Disease, Sapienza University of Rome, Sant'Andrea Hospital, 
      Rome, Italy; Unit of Gastrointestinal and Neuroendocrine Tumors, European 
      Institute of Oncology, Milan, Italy; Department of Medical Oncology, Fondazione 
      IRCCS Istituto Nazionale Tumori, Milan, Italy; Oncology and Hematology, 
      Policlinico di Modena, Italy; Section of Endocrinology and Internal Medicine, 
      Department of Medical Sciences, University of Ferrara, Ferrara, Italy; 
      Departments of Endocrinology and Oncologia Medica, Universita Cattolica del S. 
      Cuore, Rome, Italy; Departments of Medical and Surgical Sciences and Medical 
      Oncology, S. Orsola-Malpighi Hospital, University of Bologna, Bologna, Italy; 
      Oncology, Antonio Cardarelli Hospital, Naples, Italy; Division of Medical 
      Oncology and Endocrinology Unit, Regina Elena National Cancer Institute Rome, 
      IRCCS, Rome, Italy; Oncology, San Luigi Gonzaga Hospital, Orbassano, Torino, 
      Italy; Department of Clinical Medicine and Surgery, Federico II University of 
      Naples, Naples, Italy; Oncology, Fondazione Poliambulanza, Brescia, Italy; 
      Oncology, Istituto Oncologico Veneto, Padova, Italy; Departments of Medical 
      Oncology and Pancreatic Surgery, AOU Ospedali Riuniti, Universita Politecnica 
      delle Marche, Ancona, Italy; Oncology, S. Croce e Carle Hospital, Cuneo, Italy; 
      Department of Medical Oncology A, IRCCS AOU San Martino-IST, Genova, Italy; 
      Oncologia Medica 1, Azienda Ospedaliero-Universitaria Careggi, Florence, Italy; 
      Oncology, Niguarda Cancer Center, Ospedale Niguarda Ca' Granda, Milan, Italy; 
      Oncologia, Spedali Civili di Brescia, University of Brescia, Brescia, Italy.
FAU - Cascinu, Stefano
AU  - Cascinu S
AD  - Digestive and Liver Disease, Sapienza University of Rome, Sant'Andrea Hospital, 
      Rome, Italy; Unit of Gastrointestinal and Neuroendocrine Tumors, European 
      Institute of Oncology, Milan, Italy; Department of Medical Oncology, Fondazione 
      IRCCS Istituto Nazionale Tumori, Milan, Italy; Oncology and Hematology, 
      Policlinico di Modena, Italy; Section of Endocrinology and Internal Medicine, 
      Department of Medical Sciences, University of Ferrara, Ferrara, Italy; 
      Departments of Endocrinology and Oncologia Medica, Universita Cattolica del S. 
      Cuore, Rome, Italy; Departments of Medical and Surgical Sciences and Medical 
      Oncology, S. Orsola-Malpighi Hospital, University of Bologna, Bologna, Italy; 
      Oncology, Antonio Cardarelli Hospital, Naples, Italy; Division of Medical 
      Oncology and Endocrinology Unit, Regina Elena National Cancer Institute Rome, 
      IRCCS, Rome, Italy; Oncology, San Luigi Gonzaga Hospital, Orbassano, Torino, 
      Italy; Department of Clinical Medicine and Surgery, Federico II University of 
      Naples, Naples, Italy; Oncology, Fondazione Poliambulanza, Brescia, Italy; 
      Oncology, Istituto Oncologico Veneto, Padova, Italy; Departments of Medical 
      Oncology and Pancreatic Surgery, AOU Ospedali Riuniti, Universita Politecnica 
      delle Marche, Ancona, Italy; Oncology, S. Croce e Carle Hospital, Cuneo, Italy; 
      Department of Medical Oncology A, IRCCS AOU San Martino-IST, Genova, Italy; 
      Oncologia Medica 1, Azienda Ospedaliero-Universitaria Careggi, Florence, Italy; 
      Oncology, Niguarda Cancer Center, Ospedale Niguarda Ca' Granda, Milan, Italy; 
      Oncologia, Spedali Civili di Brescia, University of Brescia, Brescia, Italy.
FAU - Merlano, Marco
AU  - Merlano M
AD  - Digestive and Liver Disease, Sapienza University of Rome, Sant'Andrea Hospital, 
      Rome, Italy; Unit of Gastrointestinal and Neuroendocrine Tumors, European 
      Institute of Oncology, Milan, Italy; Department of Medical Oncology, Fondazione 
      IRCCS Istituto Nazionale Tumori, Milan, Italy; Oncology and Hematology, 
      Policlinico di Modena, Italy; Section of Endocrinology and Internal Medicine, 
      Department of Medical Sciences, University of Ferrara, Ferrara, Italy; 
      Departments of Endocrinology and Oncologia Medica, Universita Cattolica del S. 
      Cuore, Rome, Italy; Departments of Medical and Surgical Sciences and Medical 
      Oncology, S. Orsola-Malpighi Hospital, University of Bologna, Bologna, Italy; 
      Oncology, Antonio Cardarelli Hospital, Naples, Italy; Division of Medical 
      Oncology and Endocrinology Unit, Regina Elena National Cancer Institute Rome, 
      IRCCS, Rome, Italy; Oncology, San Luigi Gonzaga Hospital, Orbassano, Torino, 
      Italy; Department of Clinical Medicine and Surgery, Federico II University of 
      Naples, Naples, Italy; Oncology, Fondazione Poliambulanza, Brescia, Italy; 
      Oncology, Istituto Oncologico Veneto, Padova, Italy; Departments of Medical 
      Oncology and Pancreatic Surgery, AOU Ospedali Riuniti, Universita Politecnica 
      delle Marche, Ancona, Italy; Oncology, S. Croce e Carle Hospital, Cuneo, Italy; 
      Department of Medical Oncology A, IRCCS AOU San Martino-IST, Genova, Italy; 
      Oncologia Medica 1, Azienda Ospedaliero-Universitaria Careggi, Florence, Italy; 
      Oncology, Niguarda Cancer Center, Ospedale Niguarda Ca' Granda, Milan, Italy; 
      Oncologia, Spedali Civili di Brescia, University of Brescia, Brescia, Italy.
FAU - Chiara, Silvana
AU  - Chiara S
AD  - Digestive and Liver Disease, Sapienza University of Rome, Sant'Andrea Hospital, 
      Rome, Italy; Unit of Gastrointestinal and Neuroendocrine Tumors, European 
      Institute of Oncology, Milan, Italy; Department of Medical Oncology, Fondazione 
      IRCCS Istituto Nazionale Tumori, Milan, Italy; Oncology and Hematology, 
      Policlinico di Modena, Italy; Section of Endocrinology and Internal Medicine, 
      Department of Medical Sciences, University of Ferrara, Ferrara, Italy; 
      Departments of Endocrinology and Oncologia Medica, Universita Cattolica del S. 
      Cuore, Rome, Italy; Departments of Medical and Surgical Sciences and Medical 
      Oncology, S. Orsola-Malpighi Hospital, University of Bologna, Bologna, Italy; 
      Oncology, Antonio Cardarelli Hospital, Naples, Italy; Division of Medical 
      Oncology and Endocrinology Unit, Regina Elena National Cancer Institute Rome, 
      IRCCS, Rome, Italy; Oncology, San Luigi Gonzaga Hospital, Orbassano, Torino, 
      Italy; Department of Clinical Medicine and Surgery, Federico II University of 
      Naples, Naples, Italy; Oncology, Fondazione Poliambulanza, Brescia, Italy; 
      Oncology, Istituto Oncologico Veneto, Padova, Italy; Departments of Medical 
      Oncology and Pancreatic Surgery, AOU Ospedali Riuniti, Universita Politecnica 
      delle Marche, Ancona, Italy; Oncology, S. Croce e Carle Hospital, Cuneo, Italy; 
      Department of Medical Oncology A, IRCCS AOU San Martino-IST, Genova, Italy; 
      Oncologia Medica 1, Azienda Ospedaliero-Universitaria Careggi, Florence, Italy; 
      Oncology, Niguarda Cancer Center, Ospedale Niguarda Ca' Granda, Milan, Italy; 
      Oncologia, Spedali Civili di Brescia, University of Brescia, Brescia, Italy.
FAU - Antonuzzo, Lorenzo
AU  - Antonuzzo L
AD  - Digestive and Liver Disease, Sapienza University of Rome, Sant'Andrea Hospital, 
      Rome, Italy; Unit of Gastrointestinal and Neuroendocrine Tumors, European 
      Institute of Oncology, Milan, Italy; Department of Medical Oncology, Fondazione 
      IRCCS Istituto Nazionale Tumori, Milan, Italy; Oncology and Hematology, 
      Policlinico di Modena, Italy; Section of Endocrinology and Internal Medicine, 
      Department of Medical Sciences, University of Ferrara, Ferrara, Italy; 
      Departments of Endocrinology and Oncologia Medica, Universita Cattolica del S. 
      Cuore, Rome, Italy; Departments of Medical and Surgical Sciences and Medical 
      Oncology, S. Orsola-Malpighi Hospital, University of Bologna, Bologna, Italy; 
      Oncology, Antonio Cardarelli Hospital, Naples, Italy; Division of Medical 
      Oncology and Endocrinology Unit, Regina Elena National Cancer Institute Rome, 
      IRCCS, Rome, Italy; Oncology, San Luigi Gonzaga Hospital, Orbassano, Torino, 
      Italy; Department of Clinical Medicine and Surgery, Federico II University of 
      Naples, Naples, Italy; Oncology, Fondazione Poliambulanza, Brescia, Italy; 
      Oncology, Istituto Oncologico Veneto, Padova, Italy; Departments of Medical 
      Oncology and Pancreatic Surgery, AOU Ospedali Riuniti, Universita Politecnica 
      delle Marche, Ancona, Italy; Oncology, S. Croce e Carle Hospital, Cuneo, Italy; 
      Department of Medical Oncology A, IRCCS AOU San Martino-IST, Genova, Italy; 
      Oncologia Medica 1, Azienda Ospedaliero-Universitaria Careggi, Florence, Italy; 
      Oncology, Niguarda Cancer Center, Ospedale Niguarda Ca' Granda, Milan, Italy; 
      Oncologia, Spedali Civili di Brescia, University of Brescia, Brescia, Italy.
FAU - Funaioli, Chiara
AU  - Funaioli C
AD  - Digestive and Liver Disease, Sapienza University of Rome, Sant'Andrea Hospital, 
      Rome, Italy; Unit of Gastrointestinal and Neuroendocrine Tumors, European 
      Institute of Oncology, Milan, Italy; Department of Medical Oncology, Fondazione 
      IRCCS Istituto Nazionale Tumori, Milan, Italy; Oncology and Hematology, 
      Policlinico di Modena, Italy; Section of Endocrinology and Internal Medicine, 
      Department of Medical Sciences, University of Ferrara, Ferrara, Italy; 
      Departments of Endocrinology and Oncologia Medica, Universita Cattolica del S. 
      Cuore, Rome, Italy; Departments of Medical and Surgical Sciences and Medical 
      Oncology, S. Orsola-Malpighi Hospital, University of Bologna, Bologna, Italy; 
      Oncology, Antonio Cardarelli Hospital, Naples, Italy; Division of Medical 
      Oncology and Endocrinology Unit, Regina Elena National Cancer Institute Rome, 
      IRCCS, Rome, Italy; Oncology, San Luigi Gonzaga Hospital, Orbassano, Torino, 
      Italy; Department of Clinical Medicine and Surgery, Federico II University of 
      Naples, Naples, Italy; Oncology, Fondazione Poliambulanza, Brescia, Italy; 
      Oncology, Istituto Oncologico Veneto, Padova, Italy; Departments of Medical 
      Oncology and Pancreatic Surgery, AOU Ospedali Riuniti, Universita Politecnica 
      delle Marche, Ancona, Italy; Oncology, S. Croce e Carle Hospital, Cuneo, Italy; 
      Department of Medical Oncology A, IRCCS AOU San Martino-IST, Genova, Italy; 
      Oncologia Medica 1, Azienda Ospedaliero-Universitaria Careggi, Florence, Italy; 
      Oncology, Niguarda Cancer Center, Ospedale Niguarda Ca' Granda, Milan, Italy; 
      Oncologia, Spedali Civili di Brescia, University of Brescia, Brescia, Italy.
FAU - Spada, Francesca
AU  - Spada F
AD  - Digestive and Liver Disease, Sapienza University of Rome, Sant'Andrea Hospital, 
      Rome, Italy; Unit of Gastrointestinal and Neuroendocrine Tumors, European 
      Institute of Oncology, Milan, Italy; Department of Medical Oncology, Fondazione 
      IRCCS Istituto Nazionale Tumori, Milan, Italy; Oncology and Hematology, 
      Policlinico di Modena, Italy; Section of Endocrinology and Internal Medicine, 
      Department of Medical Sciences, University of Ferrara, Ferrara, Italy; 
      Departments of Endocrinology and Oncologia Medica, Universita Cattolica del S. 
      Cuore, Rome, Italy; Departments of Medical and Surgical Sciences and Medical 
      Oncology, S. Orsola-Malpighi Hospital, University of Bologna, Bologna, Italy; 
      Oncology, Antonio Cardarelli Hospital, Naples, Italy; Division of Medical 
      Oncology and Endocrinology Unit, Regina Elena National Cancer Institute Rome, 
      IRCCS, Rome, Italy; Oncology, San Luigi Gonzaga Hospital, Orbassano, Torino, 
      Italy; Department of Clinical Medicine and Surgery, Federico II University of 
      Naples, Naples, Italy; Oncology, Fondazione Poliambulanza, Brescia, Italy; 
      Oncology, Istituto Oncologico Veneto, Padova, Italy; Departments of Medical 
      Oncology and Pancreatic Surgery, AOU Ospedali Riuniti, Universita Politecnica 
      delle Marche, Ancona, Italy; Oncology, S. Croce e Carle Hospital, Cuneo, Italy; 
      Department of Medical Oncology A, IRCCS AOU San Martino-IST, Genova, Italy; 
      Oncologia Medica 1, Azienda Ospedaliero-Universitaria Careggi, Florence, Italy; 
      Oncology, Niguarda Cancer Center, Ospedale Niguarda Ca' Granda, Milan, Italy; 
      Oncologia, Spedali Civili di Brescia, University of Brescia, Brescia, Italy.
FAU - Pusceddu, Sara
AU  - Pusceddu S
AD  - Digestive and Liver Disease, Sapienza University of Rome, Sant'Andrea Hospital, 
      Rome, Italy; Unit of Gastrointestinal and Neuroendocrine Tumors, European 
      Institute of Oncology, Milan, Italy; Department of Medical Oncology, Fondazione 
      IRCCS Istituto Nazionale Tumori, Milan, Italy; Oncology and Hematology, 
      Policlinico di Modena, Italy; Section of Endocrinology and Internal Medicine, 
      Department of Medical Sciences, University of Ferrara, Ferrara, Italy; 
      Departments of Endocrinology and Oncologia Medica, Universita Cattolica del S. 
      Cuore, Rome, Italy; Departments of Medical and Surgical Sciences and Medical 
      Oncology, S. Orsola-Malpighi Hospital, University of Bologna, Bologna, Italy; 
      Oncology, Antonio Cardarelli Hospital, Naples, Italy; Division of Medical 
      Oncology and Endocrinology Unit, Regina Elena National Cancer Institute Rome, 
      IRCCS, Rome, Italy; Oncology, San Luigi Gonzaga Hospital, Orbassano, Torino, 
      Italy; Department of Clinical Medicine and Surgery, Federico II University of 
      Naples, Naples, Italy; Oncology, Fondazione Poliambulanza, Brescia, Italy; 
      Oncology, Istituto Oncologico Veneto, Padova, Italy; Departments of Medical 
      Oncology and Pancreatic Surgery, AOU Ospedali Riuniti, Universita Politecnica 
      delle Marche, Ancona, Italy; Oncology, S. Croce e Carle Hospital, Cuneo, Italy; 
      Department of Medical Oncology A, IRCCS AOU San Martino-IST, Genova, Italy; 
      Oncologia Medica 1, Azienda Ospedaliero-Universitaria Careggi, Florence, Italy; 
      Oncology, Niguarda Cancer Center, Ospedale Niguarda Ca' Granda, Milan, Italy; 
      Oncologia, Spedali Civili di Brescia, University of Brescia, Brescia, Italy.
FAU - Fontana, Annalisa
AU  - Fontana A
AD  - Digestive and Liver Disease, Sapienza University of Rome, Sant'Andrea Hospital, 
      Rome, Italy; Unit of Gastrointestinal and Neuroendocrine Tumors, European 
      Institute of Oncology, Milan, Italy; Department of Medical Oncology, Fondazione 
      IRCCS Istituto Nazionale Tumori, Milan, Italy; Oncology and Hematology, 
      Policlinico di Modena, Italy; Section of Endocrinology and Internal Medicine, 
      Department of Medical Sciences, University of Ferrara, Ferrara, Italy; 
      Departments of Endocrinology and Oncologia Medica, Universita Cattolica del S. 
      Cuore, Rome, Italy; Departments of Medical and Surgical Sciences and Medical 
      Oncology, S. Orsola-Malpighi Hospital, University of Bologna, Bologna, Italy; 
      Oncology, Antonio Cardarelli Hospital, Naples, Italy; Division of Medical 
      Oncology and Endocrinology Unit, Regina Elena National Cancer Institute Rome, 
      IRCCS, Rome, Italy; Oncology, San Luigi Gonzaga Hospital, Orbassano, Torino, 
      Italy; Department of Clinical Medicine and Surgery, Federico II University of 
      Naples, Naples, Italy; Oncology, Fondazione Poliambulanza, Brescia, Italy; 
      Oncology, Istituto Oncologico Veneto, Padova, Italy; Departments of Medical 
      Oncology and Pancreatic Surgery, AOU Ospedali Riuniti, Universita Politecnica 
      delle Marche, Ancona, Italy; Oncology, S. Croce e Carle Hospital, Cuneo, Italy; 
      Department of Medical Oncology A, IRCCS AOU San Martino-IST, Genova, Italy; 
      Oncologia Medica 1, Azienda Ospedaliero-Universitaria Careggi, Florence, Italy; 
      Oncology, Niguarda Cancer Center, Ospedale Niguarda Ca' Granda, Milan, Italy; 
      Oncologia, Spedali Civili di Brescia, University of Brescia, Brescia, Italy.
FAU - Ambrosio, Maria Rosaria
AU  - Ambrosio MR
AD  - Digestive and Liver Disease, Sapienza University of Rome, Sant'Andrea Hospital, 
      Rome, Italy; Unit of Gastrointestinal and Neuroendocrine Tumors, European 
      Institute of Oncology, Milan, Italy; Department of Medical Oncology, Fondazione 
      IRCCS Istituto Nazionale Tumori, Milan, Italy; Oncology and Hematology, 
      Policlinico di Modena, Italy; Section of Endocrinology and Internal Medicine, 
      Department of Medical Sciences, University of Ferrara, Ferrara, Italy; 
      Departments of Endocrinology and Oncologia Medica, Universita Cattolica del S. 
      Cuore, Rome, Italy; Departments of Medical and Surgical Sciences and Medical 
      Oncology, S. Orsola-Malpighi Hospital, University of Bologna, Bologna, Italy; 
      Oncology, Antonio Cardarelli Hospital, Naples, Italy; Division of Medical 
      Oncology and Endocrinology Unit, Regina Elena National Cancer Institute Rome, 
      IRCCS, Rome, Italy; Oncology, San Luigi Gonzaga Hospital, Orbassano, Torino, 
      Italy; Department of Clinical Medicine and Surgery, Federico II University of 
      Naples, Naples, Italy; Oncology, Fondazione Poliambulanza, Brescia, Italy; 
      Oncology, Istituto Oncologico Veneto, Padova, Italy; Departments of Medical 
      Oncology and Pancreatic Surgery, AOU Ospedali Riuniti, Universita Politecnica 
      delle Marche, Ancona, Italy; Oncology, S. Croce e Carle Hospital, Cuneo, Italy; 
      Department of Medical Oncology A, IRCCS AOU San Martino-IST, Genova, Italy; 
      Oncologia Medica 1, Azienda Ospedaliero-Universitaria Careggi, Florence, Italy; 
      Oncology, Niguarda Cancer Center, Ospedale Niguarda Ca' Granda, Milan, Italy; 
      Oncologia, Spedali Civili di Brescia, University of Brescia, Brescia, Italy.
FAU - Cassano, Alessandra
AU  - Cassano A
AD  - Digestive and Liver Disease, Sapienza University of Rome, Sant'Andrea Hospital, 
      Rome, Italy; Unit of Gastrointestinal and Neuroendocrine Tumors, European 
      Institute of Oncology, Milan, Italy; Department of Medical Oncology, Fondazione 
      IRCCS Istituto Nazionale Tumori, Milan, Italy; Oncology and Hematology, 
      Policlinico di Modena, Italy; Section of Endocrinology and Internal Medicine, 
      Department of Medical Sciences, University of Ferrara, Ferrara, Italy; 
      Departments of Endocrinology and Oncologia Medica, Universita Cattolica del S. 
      Cuore, Rome, Italy; Departments of Medical and Surgical Sciences and Medical 
      Oncology, S. Orsola-Malpighi Hospital, University of Bologna, Bologna, Italy; 
      Oncology, Antonio Cardarelli Hospital, Naples, Italy; Division of Medical 
      Oncology and Endocrinology Unit, Regina Elena National Cancer Institute Rome, 
      IRCCS, Rome, Italy; Oncology, San Luigi Gonzaga Hospital, Orbassano, Torino, 
      Italy; Department of Clinical Medicine and Surgery, Federico II University of 
      Naples, Naples, Italy; Oncology, Fondazione Poliambulanza, Brescia, Italy; 
      Oncology, Istituto Oncologico Veneto, Padova, Italy; Departments of Medical 
      Oncology and Pancreatic Surgery, AOU Ospedali Riuniti, Universita Politecnica 
      delle Marche, Ancona, Italy; Oncology, S. Croce e Carle Hospital, Cuneo, Italy; 
      Department of Medical Oncology A, IRCCS AOU San Martino-IST, Genova, Italy; 
      Oncologia Medica 1, Azienda Ospedaliero-Universitaria Careggi, Florence, Italy; 
      Oncology, Niguarda Cancer Center, Ospedale Niguarda Ca' Granda, Milan, Italy; 
      Oncologia, Spedali Civili di Brescia, University of Brescia, Brescia, Italy.
FAU - Campana, Davide
AU  - Campana D
AD  - Digestive and Liver Disease, Sapienza University of Rome, Sant'Andrea Hospital, 
      Rome, Italy; Unit of Gastrointestinal and Neuroendocrine Tumors, European 
      Institute of Oncology, Milan, Italy; Department of Medical Oncology, Fondazione 
      IRCCS Istituto Nazionale Tumori, Milan, Italy; Oncology and Hematology, 
      Policlinico di Modena, Italy; Section of Endocrinology and Internal Medicine, 
      Department of Medical Sciences, University of Ferrara, Ferrara, Italy; 
      Departments of Endocrinology and Oncologia Medica, Universita Cattolica del S. 
      Cuore, Rome, Italy; Departments of Medical and Surgical Sciences and Medical 
      Oncology, S. Orsola-Malpighi Hospital, University of Bologna, Bologna, Italy; 
      Oncology, Antonio Cardarelli Hospital, Naples, Italy; Division of Medical 
      Oncology and Endocrinology Unit, Regina Elena National Cancer Institute Rome, 
      IRCCS, Rome, Italy; Oncology, San Luigi Gonzaga Hospital, Orbassano, Torino, 
      Italy; Department of Clinical Medicine and Surgery, Federico II University of 
      Naples, Naples, Italy; Oncology, Fondazione Poliambulanza, Brescia, Italy; 
      Oncology, Istituto Oncologico Veneto, Padova, Italy; Departments of Medical 
      Oncology and Pancreatic Surgery, AOU Ospedali Riuniti, Universita Politecnica 
      delle Marche, Ancona, Italy; Oncology, S. Croce e Carle Hospital, Cuneo, Italy; 
      Department of Medical Oncology A, IRCCS AOU San Martino-IST, Genova, Italy; 
      Oncologia Medica 1, Azienda Ospedaliero-Universitaria Careggi, Florence, Italy; 
      Oncology, Niguarda Cancer Center, Ospedale Niguarda Ca' Granda, Milan, Italy; 
      Oncologia, Spedali Civili di Brescia, University of Brescia, Brescia, Italy.
FAU - Carteni, Giacomo
AU  - Carteni G
AD  - Digestive and Liver Disease, Sapienza University of Rome, Sant'Andrea Hospital, 
      Rome, Italy; Unit of Gastrointestinal and Neuroendocrine Tumors, European 
      Institute of Oncology, Milan, Italy; Department of Medical Oncology, Fondazione 
      IRCCS Istituto Nazionale Tumori, Milan, Italy; Oncology and Hematology, 
      Policlinico di Modena, Italy; Section of Endocrinology and Internal Medicine, 
      Department of Medical Sciences, University of Ferrara, Ferrara, Italy; 
      Departments of Endocrinology and Oncologia Medica, Universita Cattolica del S. 
      Cuore, Rome, Italy; Departments of Medical and Surgical Sciences and Medical 
      Oncology, S. Orsola-Malpighi Hospital, University of Bologna, Bologna, Italy; 
      Oncology, Antonio Cardarelli Hospital, Naples, Italy; Division of Medical 
      Oncology and Endocrinology Unit, Regina Elena National Cancer Institute Rome, 
      IRCCS, Rome, Italy; Oncology, San Luigi Gonzaga Hospital, Orbassano, Torino, 
      Italy; Department of Clinical Medicine and Surgery, Federico II University of 
      Naples, Naples, Italy; Oncology, Fondazione Poliambulanza, Brescia, Italy; 
      Oncology, Istituto Oncologico Veneto, Padova, Italy; Departments of Medical 
      Oncology and Pancreatic Surgery, AOU Ospedali Riuniti, Universita Politecnica 
      delle Marche, Ancona, Italy; Oncology, S. Croce e Carle Hospital, Cuneo, Italy; 
      Department of Medical Oncology A, IRCCS AOU San Martino-IST, Genova, Italy; 
      Oncologia Medica 1, Azienda Ospedaliero-Universitaria Careggi, Florence, Italy; 
      Oncology, Niguarda Cancer Center, Ospedale Niguarda Ca' Granda, Milan, Italy; 
      Oncologia, Spedali Civili di Brescia, University of Brescia, Brescia, Italy.
FAU - Appetecchia, Marialuisa
AU  - Appetecchia M
AD  - Digestive and Liver Disease, Sapienza University of Rome, Sant'Andrea Hospital, 
      Rome, Italy; Unit of Gastrointestinal and Neuroendocrine Tumors, European 
      Institute of Oncology, Milan, Italy; Department of Medical Oncology, Fondazione 
      IRCCS Istituto Nazionale Tumori, Milan, Italy; Oncology and Hematology, 
      Policlinico di Modena, Italy; Section of Endocrinology and Internal Medicine, 
      Department of Medical Sciences, University of Ferrara, Ferrara, Italy; 
      Departments of Endocrinology and Oncologia Medica, Universita Cattolica del S. 
      Cuore, Rome, Italy; Departments of Medical and Surgical Sciences and Medical 
      Oncology, S. Orsola-Malpighi Hospital, University of Bologna, Bologna, Italy; 
      Oncology, Antonio Cardarelli Hospital, Naples, Italy; Division of Medical 
      Oncology and Endocrinology Unit, Regina Elena National Cancer Institute Rome, 
      IRCCS, Rome, Italy; Oncology, San Luigi Gonzaga Hospital, Orbassano, Torino, 
      Italy; Department of Clinical Medicine and Surgery, Federico II University of 
      Naples, Naples, Italy; Oncology, Fondazione Poliambulanza, Brescia, Italy; 
      Oncology, Istituto Oncologico Veneto, Padova, Italy; Departments of Medical 
      Oncology and Pancreatic Surgery, AOU Ospedali Riuniti, Universita Politecnica 
      delle Marche, Ancona, Italy; Oncology, S. Croce e Carle Hospital, Cuneo, Italy; 
      Department of Medical Oncology A, IRCCS AOU San Martino-IST, Genova, Italy; 
      Oncologia Medica 1, Azienda Ospedaliero-Universitaria Careggi, Florence, Italy; 
      Oncology, Niguarda Cancer Center, Ospedale Niguarda Ca' Granda, Milan, Italy; 
      Oncologia, Spedali Civili di Brescia, University of Brescia, Brescia, Italy.
FAU - Berruti, Alfredo
AU  - Berruti A
AD  - Digestive and Liver Disease, Sapienza University of Rome, Sant'Andrea Hospital, 
      Rome, Italy; Unit of Gastrointestinal and Neuroendocrine Tumors, European 
      Institute of Oncology, Milan, Italy; Department of Medical Oncology, Fondazione 
      IRCCS Istituto Nazionale Tumori, Milan, Italy; Oncology and Hematology, 
      Policlinico di Modena, Italy; Section of Endocrinology and Internal Medicine, 
      Department of Medical Sciences, University of Ferrara, Ferrara, Italy; 
      Departments of Endocrinology and Oncologia Medica, Universita Cattolica del S. 
      Cuore, Rome, Italy; Departments of Medical and Surgical Sciences and Medical 
      Oncology, S. Orsola-Malpighi Hospital, University of Bologna, Bologna, Italy; 
      Oncology, Antonio Cardarelli Hospital, Naples, Italy; Division of Medical 
      Oncology and Endocrinology Unit, Regina Elena National Cancer Institute Rome, 
      IRCCS, Rome, Italy; Oncology, San Luigi Gonzaga Hospital, Orbassano, Torino, 
      Italy; Department of Clinical Medicine and Surgery, Federico II University of 
      Naples, Naples, Italy; Oncology, Fondazione Poliambulanza, Brescia, Italy; 
      Oncology, Istituto Oncologico Veneto, Padova, Italy; Departments of Medical 
      Oncology and Pancreatic Surgery, AOU Ospedali Riuniti, Universita Politecnica 
      delle Marche, Ancona, Italy; Oncology, S. Croce e Carle Hospital, Cuneo, Italy; 
      Department of Medical Oncology A, IRCCS AOU San Martino-IST, Genova, Italy; 
      Oncologia Medica 1, Azienda Ospedaliero-Universitaria Careggi, Florence, Italy; 
      Oncology, Niguarda Cancer Center, Ospedale Niguarda Ca' Granda, Milan, Italy; 
      Oncologia, Spedali Civili di Brescia, University of Brescia, Brescia, Italy.
FAU - Colao, Annamaria
AU  - Colao A
AD  - Digestive and Liver Disease, Sapienza University of Rome, Sant'Andrea Hospital, 
      Rome, Italy; Unit of Gastrointestinal and Neuroendocrine Tumors, European 
      Institute of Oncology, Milan, Italy; Department of Medical Oncology, Fondazione 
      IRCCS Istituto Nazionale Tumori, Milan, Italy; Oncology and Hematology, 
      Policlinico di Modena, Italy; Section of Endocrinology and Internal Medicine, 
      Department of Medical Sciences, University of Ferrara, Ferrara, Italy; 
      Departments of Endocrinology and Oncologia Medica, Universita Cattolica del S. 
      Cuore, Rome, Italy; Departments of Medical and Surgical Sciences and Medical 
      Oncology, S. Orsola-Malpighi Hospital, University of Bologna, Bologna, Italy; 
      Oncology, Antonio Cardarelli Hospital, Naples, Italy; Division of Medical 
      Oncology and Endocrinology Unit, Regina Elena National Cancer Institute Rome, 
      IRCCS, Rome, Italy; Oncology, San Luigi Gonzaga Hospital, Orbassano, Torino, 
      Italy; Department of Clinical Medicine and Surgery, Federico II University of 
      Naples, Naples, Italy; Oncology, Fondazione Poliambulanza, Brescia, Italy; 
      Oncology, Istituto Oncologico Veneto, Padova, Italy; Departments of Medical 
      Oncology and Pancreatic Surgery, AOU Ospedali Riuniti, Universita Politecnica 
      delle Marche, Ancona, Italy; Oncology, S. Croce e Carle Hospital, Cuneo, Italy; 
      Department of Medical Oncology A, IRCCS AOU San Martino-IST, Genova, Italy; 
      Oncologia Medica 1, Azienda Ospedaliero-Universitaria Careggi, Florence, Italy; 
      Oncology, Niguarda Cancer Center, Ospedale Niguarda Ca' Granda, Milan, Italy; 
      Oncologia, Spedali Civili di Brescia, University of Brescia, Brescia, Italy.
FAU - Falconi, Massimo
AU  - Falconi M
AD  - Digestive and Liver Disease, Sapienza University of Rome, Sant'Andrea Hospital, 
      Rome, Italy; Unit of Gastrointestinal and Neuroendocrine Tumors, European 
      Institute of Oncology, Milan, Italy; Department of Medical Oncology, Fondazione 
      IRCCS Istituto Nazionale Tumori, Milan, Italy; Oncology and Hematology, 
      Policlinico di Modena, Italy; Section of Endocrinology and Internal Medicine, 
      Department of Medical Sciences, University of Ferrara, Ferrara, Italy; 
      Departments of Endocrinology and Oncologia Medica, Universita Cattolica del S. 
      Cuore, Rome, Italy; Departments of Medical and Surgical Sciences and Medical 
      Oncology, S. Orsola-Malpighi Hospital, University of Bologna, Bologna, Italy; 
      Oncology, Antonio Cardarelli Hospital, Naples, Italy; Division of Medical 
      Oncology and Endocrinology Unit, Regina Elena National Cancer Institute Rome, 
      IRCCS, Rome, Italy; Oncology, San Luigi Gonzaga Hospital, Orbassano, Torino, 
      Italy; Department of Clinical Medicine and Surgery, Federico II University of 
      Naples, Naples, Italy; Oncology, Fondazione Poliambulanza, Brescia, Italy; 
      Oncology, Istituto Oncologico Veneto, Padova, Italy; Departments of Medical 
      Oncology and Pancreatic Surgery, AOU Ospedali Riuniti, Universita Politecnica 
      delle Marche, Ancona, Italy; Oncology, S. Croce e Carle Hospital, Cuneo, Italy; 
      Department of Medical Oncology A, IRCCS AOU San Martino-IST, Genova, Italy; 
      Oncologia Medica 1, Azienda Ospedaliero-Universitaria Careggi, Florence, Italy; 
      Oncology, Niguarda Cancer Center, Ospedale Niguarda Ca' Granda, Milan, Italy; 
      Oncologia, Spedali Civili di Brescia, University of Brescia, Brescia, Italy.
FAU - Delle Fave, Gianfranco
AU  - Delle Fave G
AD  - Digestive and Liver Disease, Sapienza University of Rome, Sant'Andrea Hospital, 
      Rome, Italy; Unit of Gastrointestinal and Neuroendocrine Tumors, European 
      Institute of Oncology, Milan, Italy; Department of Medical Oncology, Fondazione 
      IRCCS Istituto Nazionale Tumori, Milan, Italy; Oncology and Hematology, 
      Policlinico di Modena, Italy; Section of Endocrinology and Internal Medicine, 
      Department of Medical Sciences, University of Ferrara, Ferrara, Italy; 
      Departments of Endocrinology and Oncologia Medica, Universita Cattolica del S. 
      Cuore, Rome, Italy; Departments of Medical and Surgical Sciences and Medical 
      Oncology, S. Orsola-Malpighi Hospital, University of Bologna, Bologna, Italy; 
      Oncology, Antonio Cardarelli Hospital, Naples, Italy; Division of Medical 
      Oncology and Endocrinology Unit, Regina Elena National Cancer Institute Rome, 
      IRCCS, Rome, Italy; Oncology, San Luigi Gonzaga Hospital, Orbassano, Torino, 
      Italy; Department of Clinical Medicine and Surgery, Federico II University of 
      Naples, Naples, Italy; Oncology, Fondazione Poliambulanza, Brescia, Italy; 
      Oncology, Istituto Oncologico Veneto, Padova, Italy; Departments of Medical 
      Oncology and Pancreatic Surgery, AOU Ospedali Riuniti, Universita Politecnica 
      delle Marche, Ancona, Italy; Oncology, S. Croce e Carle Hospital, Cuneo, Italy; 
      Department of Medical Oncology A, IRCCS AOU San Martino-IST, Genova, Italy; 
      Oncologia Medica 1, Azienda Ospedaliero-Universitaria Careggi, Florence, Italy; 
      Oncology, Niguarda Cancer Center, Ospedale Niguarda Ca' Granda, Milan, Italy; 
      Oncologia, Spedali Civili di Brescia, University of Brescia, Brescia, Italy 
      gianfranco.dellefave@uniroma1.it.
LA  - eng
PT  - Clinical Trial
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20140812
PL  - England
TA  - Oncologist
JT  - The oncologist
JID - 9607837
RN  - 9HW64Q8G6G (Everolimus)
RN  - RWM8CCW8GP (Octreotide)
RN  - W36ZG6FT64 (Sirolimus)
SB  - IM
EIN - Oncologist. 2015 May;20(5):570. PMID: 25956900
MH  - Aged
MH  - Carcinoid Tumor/drug therapy/pathology
MH  - Compassionate Use Trials
MH  - Disease-Free Survival
MH  - Drug-Related Side Effects and Adverse Reactions/classification/*pathology
MH  - Everolimus
MH  - Female
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Neoplasm Staging
MH  - Neuroendocrine Tumors/*drug therapy/pathology
MH  - Octreotide/administration & dosage
MH  - Pancreatic Neoplasms/*drug therapy/pathology
MH  - Sirolimus/administration & dosage/adverse effects/*analogs & derivatives
PMC - PMC4153458
OTO - NOTNLM
OT  - Carcinoids
OT  - Compassionate use
OT  - Everolimus
OT  - Neuroendocrine tumors
OT  - Pancreatic endocrine tumors
OT  - Prognosis
COIS- Disclosures of potential conflicts of interest may be found at the end of this 
      article.
EDAT- 2014/08/15 06:00
MHDA- 2015/05/15 06:00
PMCR- 2015/09/01
CRDT- 2014/08/14 06:00
PHST- 2014/08/14 06:00 [entrez]
PHST- 2014/08/15 06:00 [pubmed]
PHST- 2015/05/15 06:00 [medline]
PHST- 2015/09/01 00:00 [pmc-release]
AID - theoncologist.2014-0037 [pii]
AID - T1437 [pii]
AID - 10.1634/theoncologist.2014-0037 [doi]
PST - ppublish
SO  - Oncologist. 2014 Sep;19(9):966-74. doi: 10.1634/theoncologist.2014-0037. Epub 
      2014 Aug 12.