PMID- 25117987 OWN - NLM STAT- MEDLINE DCOM- 20150707 LR - 20211021 IS - 1476-5640 (Electronic) IS - 0954-3007 (Print) IS - 0954-3007 (Linking) VI - 68 IP - 11 DP - 2014 Nov TI - Timing of complementary food introduction and age at diagnosis of type 1 diabetes: the SEARCH nutrition ancillary study (SNAS). PG - 1258-60 LID - 10.1038/ejcn.2014.159 [doi] AB - The association between timing of complementary food introduction and age at diagnosis of type 1 diabetes was investigated among 1077 children in the SEARCH for Diabetes in Youth study. Age at diagnosis was 5 months earlier for children introduced to sugar-sweetened beverages (SSB) in the first 12 months of life compared with those who were not (9.0+/-0.2 vs 9.5+/-0.1; P=0.02) independent of human leukocyte antigen (HLA) risk status. Analyses stratified by HLA risk status found that children with a high-risk HLA genotype had an earlier age at diagnosis if they were introduced to fruit juice in the first year of life (mean age at diagnosis=9.3+/-0.1, 9.1+/-0.1 and 9.6+/-0.2 for introduction at ⩽6 months, between 7 and 11 months and ⩾12 months, respectively; P=0.04). Introduction of SSB in the first year of life may accelerate the onset of type 1 diabetes independent of HLA risk status. FAU - Crume, T L AU - Crume TL AD - Department of Epidemiology, Colorado School of Public Health, University of Colorado Denver, Aurora, CO, USA. FAU - Crandell, J AU - Crandell J AD - Department of Nutrition, University of North Carolina at Chapel Hill School of Public Health and School of Medicine, Chapel Hill, NC, USA. FAU - Norris, J M AU - Norris JM AD - Department of Epidemiology, Colorado School of Public Health, University of Colorado Denver, Aurora, CO, USA. FAU - Dabelea, D AU - Dabelea D AD - Department of Epidemiology, Colorado School of Public Health, University of Colorado Denver, Aurora, CO, USA. FAU - Fangman, M T AU - Fangman MT AD - Department of Nutrition, University of North Carolina at Chapel Hill School of Public Health and School of Medicine, Chapel Hill, NC, USA. FAU - Pettitt, D J AU - Pettitt DJ AD - Sansum Diabetes Research Institute, Santa Barbara, CA, USA. FAU - Dolan, L AU - Dolan L AD - Cincinnati Children's Hospital, The University of Cincinnati, Cincinnati, OH, USA. FAU - Rodriguez, B L AU - Rodriguez BL AD - John A Burns School of Medicine, University of Hawaii, Kaukini Medical Center, Honolulu, HI, USA. FAU - O'Connor, R AU - O'Connor R AD - Center for Clinical and Translational Research, Division of Endocrinology, Seattle Children's Research Institute and University of Washington School of Nursing, Seattle, WA, USA. FAU - Mayer-Davis, E J AU - Mayer-Davis EJ AD - Department of Nutrition, University of North Carolina at Chapel Hill School of Public Health and School of Medicine, Chapel Hill, NC, USA. LA - eng GR - P30 DK057516/DK/NIDDK NIH HHS/United States GR - U48/CCU419249/PHS HHS/United States GR - M01 RR000069/RR/NCRR NIH HHS/United States GR - U18 DP002714/DP/NCCDPHP CDC HHS/United States GR - U01 DP000248/DP/NCCDPHP CDC HHS/United States GR - P30 DK57516/DK/NIDDK NIH HHS/United States GR - U48/CCU519239/PHS HHS/United States GR - U18DP002710-01/DP/NCCDPHP CDC HHS/United States GR - DK056350/DK/NIDDK NIH HHS/United States GR - U01 DP000250/DP/NCCDPHP CDC HHS/United States GR - HIR 10-001/HX/HSRD VA/United States GR - 1U18DP002709/DP/NCCDPHP CDC HHS/United States GR - U48/CCU819241-3/PHS HHS/United States GR - M01RR00037/RR/NCRR NIH HHS/United States GR - U01 DP000247/DP/NCCDPHP CDC HHS/United States GR - R01 DK077949/DK/NIDDK NIH HHS/United States GR - U18 DP002710/DP/NCCDPHP CDC HHS/United States GR - U18DP002714/DP/NCCDPHP CDC HHS/United States GR - U01 DP000245/DP/NCCDPHP CDC HHS/United States GR - DP-05-069/DP/NCCDPHP CDC HHS/United States GR - U18DP002708-01/DP/NCCDPHP CDC HHS/United States GR - 200-2010-35171/PHS HHS/United States GR - U48/CCU919219/PHS HHS/United States GR - M01 RR000037/RR/NCRR NIH HHS/United States GR - DP-10-001/DP/NCCDPHP CDC HHS/United States GR - U01 DP000244/DP/NCCDPHP CDC HHS/United States GR - U58CCU919256/PHS HHS/United States GR - 00097/PHS HHS/United States GR - 1UL1RR026314-01/RR/NCRR NIH HHS/United States GR - U18DP000247-06A1/DP/NCCDPHP CDC HHS/United States GR - UL1 RR029882/RR/NCRR NIH HHS/United States GR - M01 RR00069/RR/NCRR NIH HHS/United States GR - U58/CCU019235-4/PHS HHS/United States GR - U18 DP002709/DP/NCCDPHP CDC HHS/United States GR - UL1 TR001082/TR/NCATS NIH HHS/United States GR - P30 DK056350/DK/NIDDK NIH HHS/United States GR - U01 DP000246/DP/NCCDPHP CDC HHS/United States GR - U01 DP000254/DP/NCCDPHP CDC HHS/United States GR - UL1 RR026314/RR/NCRR NIH HHS/United States GR - U18 DP002708/DP/NCCDPHP CDC HHS/United States GR - UL1RR029882/RR/NCRR NIH HHS/United States PT - Journal Article PT - Research Support, N.I.H., Extramural PT - Research Support, U.S. Gov't, P.H.S. DEP - 20140813 PL - England TA - Eur J Clin Nutr JT - European journal of clinical nutrition JID - 8804070 RN - 0 (Carbohydrates) RN - 0 (HLA Antigens) SB - IM MH - Beverages/*analysis MH - Carbohydrates/administration & dosage/analysis MH - Child MH - Child, Preschool MH - Diabetes Mellitus, Type 1/*diagnosis MH - Genotype MH - HLA Antigens/genetics MH - Humans MH - Infant MH - *Infant Nutritional Physiological Phenomena MH - Retrospective Studies MH - Risk Factors MH - Surveys and Questionnaires PMC - PMC4414319 MID - NIHMS599771 EDAT- 2014/08/15 06:00 MHDA- 2015/07/08 06:00 PMCR- 2015/05/01 CRDT- 2014/08/14 06:00 PHST- 2013/08/02 00:00 [received] PHST- 2014/05/02 00:00 [revised] PHST- 2014/05/26 00:00 [accepted] PHST- 2014/08/14 06:00 [entrez] PHST- 2014/08/15 06:00 [pubmed] PHST- 2015/07/08 06:00 [medline] PHST- 2015/05/01 00:00 [pmc-release] AID - ejcn2014159 [pii] AID - 10.1038/ejcn.2014.159 [doi] PST - ppublish SO - Eur J Clin Nutr. 2014 Nov;68(11):1258-60. doi: 10.1038/ejcn.2014.159. Epub 2014 Aug 13.