PMID- 25119165
OWN - NLM
STAT- MEDLINE
DCOM- 20150729
LR  - 20211021
IS  - 1573-6903 (Electronic)
IS  - 0364-3190 (Linking)
VI  - 39
IP  - 11
DP  - 2014 Nov
TI  - Brain-derived neurotrophic factor and interleukin-6 levels in the serum and 
      cerebrospinal fluid of children with viral infection-induced encephalopathy.
PG  - 2143-9
LID - 10.1007/s11064-014-1409-9 [doi]
AB  - We investigated changes in the brain-derived neurotrophic factor (BDNF) and 
      interleukin (IL)-6 levels in pediatric patients with central nervous system (CNS) 
      infections, particularly viral infection-induced encephalopathy. Over a 5-year 
      study period, 24 children hospitalized with encephalopathy were grouped based on 
      their acute encephalopathy type (the excitotoxicity, cytokine storm, and 
      metabolic error types). Children without CNS infections served as controls. In 
      serum and cerebrospinal fluid (CSF) samples, BDNF and IL-6 levels were increased 
      in all encephalopathy groups, and significant increases were noted in the 
      influenza-associated and cytokine storm encephalopathy groups. Children with 
      sequelae showed higher BDNF and IL-6 levels than those without sequelae. In 
      pediatric patients, changes in serum and CSF BDNF and IL-6 levels may serve as a 
      prognostic index of CNS infections, particularly for the diagnosis of 
      encephalopathy and differentiation of encephalopathy types.
FAU - Morichi, Shinichiro
AU  - Morichi S
AD  - Department of Pediatrics, Tokyo Medical University, 6-7-1 Nishishinjuku, 
      Shinjuku-ku, Tokyo, 160-0023, Japan, shinichiro-m@hotmail.co.jp.
FAU - Yamanaka, Gaku
AU  - Yamanaka G
FAU - Ishida, Yu
AU  - Ishida Y
FAU - Oana, Shingo
AU  - Oana S
FAU - Kashiwagi, Yasuyo
AU  - Kashiwagi Y
FAU - Kawashima, Hisashi
AU  - Kawashima H
LA  - eng
PT  - Journal Article
DEP - 20140815
PL  - United States
TA  - Neurochem Res
JT  - Neurochemical research
JID - 7613461
RN  - 0 (Brain-Derived Neurotrophic Factor)
RN  - 0 (IL6 protein, human)
RN  - 0 (Interleukin-6)
SB  - IM
MH  - Brain Diseases/blood/cerebrospinal fluid/*virology
MH  - Brain-Derived Neurotrophic Factor/*blood/*cerebrospinal fluid
MH  - Central Nervous System Viral Diseases/*metabolism
MH  - Child
MH  - Child, Preschool
MH  - Female
MH  - Humans
MH  - Infant
MH  - Interleukin-6/*blood/*cerebrospinal fluid
MH  - Male
EDAT- 2014/08/15 06:00
MHDA- 2015/07/30 06:00
CRDT- 2014/08/15 06:00
PHST- 2014/03/31 00:00 [received]
PHST- 2014/08/04 00:00 [accepted]
PHST- 2014/07/03 00:00 [revised]
PHST- 2014/08/15 06:00 [entrez]
PHST- 2014/08/15 06:00 [pubmed]
PHST- 2015/07/30 06:00 [medline]
AID - 10.1007/s11064-014-1409-9 [doi]
PST - ppublish
SO  - Neurochem Res. 2014 Nov;39(11):2143-9. doi: 10.1007/s11064-014-1409-9. Epub 2014 
      Aug 15.