PMID- 25119778
OWN - NLM
STAT- MEDLINE
DCOM- 20151002
LR  - 20211021
IS  - 1432-1912 (Electronic)
IS  - 0028-1298 (Linking)
VI  - 388
IP  - 2
DP  - 2015 Feb
TI  - The case for extracellular Nm23-H1 as a driver of acute myeloid leukaemia (AML) 
      progression.
PG  - 225-33
LID - 10.1007/s00210-014-1027-8 [doi]
AB  - Studies in the 1990s identified a link between extracellular Nm23 proteins and 
      acute myeloid leukaemia (AML). Confidence in the importance of these observations 
      was undermined by a lack of appreciation that extracellular Nm23 proteins were 
      relevant to either normal or pathophysiology coupled with the lack of 
      demonstrable activity of Nm23 proteins against human AML cell lines. However, 
      independent studies have highlighted the importance of Nm23-H1 in AML and have 
      identified an elaborate Nm23-H1-mediated cross talk between cells within the AML 
      clone. In other studies, roles for Nm23-H1 have now also been implicated in the 
      maintenance of the stem cell state of embryonic stem (ES) cells and induced 
      pluripotent stem (IPS) cells. In this review, we have generated a unifying model 
      of the action of Nm23-H1 in AML, including previously unpublished data from our 
      laboratory, and provide arguments as to why we consider this role to be distinct 
      from that in ES and IPS cells.
FAU - Lilly, A Joshua
AU  - Lilly AJ
AD  - Cancer Research UK Manchester Institute, The University of Manchester, 
      Manchester, M20 4BX, UK.
FAU - Khanim, Farhat L
AU  - Khanim FL
FAU - Bunce, Christopher M
AU  - Bunce CM
LA  - eng
GR  - Medical Research Council/United Kingdom
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Review
DEP - 20140815
PL  - Germany
TA  - Naunyn Schmiedebergs Arch Pharmacol
JT  - Naunyn-Schmiedeberg's archives of pharmacology
JID - 0326264
RN  - 0 (Mucin-1)
RN  - 0 (NM23 Nucleoside Diphosphate Kinases)
RN  - 0 (Receptors, Cell Surface)
SB  - IM
MH  - Animals
MH  - Disease Progression
MH  - Humans
MH  - *Leukemia, Myeloid, Acute/metabolism
MH  - Mucin-1/metabolism
MH  - NM23 Nucleoside Diphosphate Kinases/*metabolism
MH  - Receptors, Cell Surface/metabolism
EDAT- 2014/08/15 06:00
MHDA- 2015/10/03 06:00
CRDT- 2014/08/15 06:00
PHST- 2014/04/27 00:00 [received]
PHST- 2014/07/23 00:00 [accepted]
PHST- 2014/08/15 06:00 [entrez]
PHST- 2014/08/15 06:00 [pubmed]
PHST- 2015/10/03 06:00 [medline]
AID - 10.1007/s00210-014-1027-8 [doi]
PST - ppublish
SO  - Naunyn Schmiedebergs Arch Pharmacol. 2015 Feb;388(2):225-33. doi: 
      10.1007/s00210-014-1027-8. Epub 2014 Aug 15.