PMID- 25120606
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20211021
IS  - 1792-0981 (Print)
IS  - 1792-1015 (Electronic)
IS  - 1792-0981 (Linking)
VI  - 8
IP  - 3
DP  - 2014 Sep
TI  - Prognostic significance of artemin and GFRalpha1 expression in laryngeal squamous 
      cell carcinoma.
PG  - 818-822
AB  - Artemin (ARTN) has been implicated in the development and progression of several 
      human malignancies. However, the clinical and prognostic significance of ARTN and 
      its receptors has not yet been investigated in human laryngeal squamous cell 
      carcinoma (LSCC). Therefore, in the present study, the protein expression of ARTN 
      and its receptor, namely GFRalpha1, was determined in 76 LSCC and 26 laryngeal polyp 
      tissue samples using immunohistochemistry. Furthermore, the clinicopathological 
      and prognostic significance of ARTN and GFRalpha1 expression was analyzed in patients 
      with LSCC. The results revealed that the expression of ARTN and GFRalpha1 was 
      significantly increased in LSCC compared with polyp tissue samples. Furthermore, 
      the expression of ARTN and GFRalpha1 was positively associated with pTNM stage in 
      LSCC. Kaplan-Meier survival analyses revealed a strong association between the 
      expression of ARTN or GFRalpha1 and the survival of patients with LSCC. Correlation 
      analysis demonstrated that the expression of ARTN was significantly correlated 
      with the expression GFRalpha1. In conclusion, the results demonstrated that ARTN and 
      GFRalpha1 may be useful predictors of disease progression and outcome in patients 
      with LSCC.
FAU - Gao, Chaobing
AU  - Gao C
AD  - Department of Otorhinolaryngology, Head and Neck Surgery, The First Affiliated 
      Hospital of Anhui Medical University, Hefei, Anhui 230022, P.R. China.
FAU - Cheng, Xingwang
AU  - Cheng X
AD  - Department of Emergency, The First Affiliated Hospital of Bengbu Medical 
      University, Bengbu, Anhui 233030, P.R. China.
FAU - Li, Xiaohong
AU  - Li X
AD  - Department of Otorhinolaryngology, Head and Neck Surgery, The First Affiliated 
      Hospital of Anhui Medical University, Hefei, Anhui 230022, P.R. China.
FAU - Tong, Busheng
AU  - Tong B
AD  - Department of Otorhinolaryngology, Head and Neck Surgery, The First Affiliated 
      Hospital of Anhui Medical University, Hefei, Anhui 230022, P.R. China.
FAU - Wu, Kaile
AU  - Wu K
AD  - Department of Otorhinolaryngology, Head and Neck Surgery, The First Affiliated 
      Hospital of Anhui Medical University, Hefei, Anhui 230022, P.R. China.
FAU - Liu, Yehai
AU  - Liu Y
AD  - Department of Otorhinolaryngology, Head and Neck Surgery, The First Affiliated 
      Hospital of Anhui Medical University, Hefei, Anhui 230022, P.R. China.
LA  - eng
PT  - Journal Article
DEP - 20140702
PL  - Greece
TA  - Exp Ther Med
JT  - Experimental and therapeutic medicine
JID - 101531947
PMC - PMC4113528
OTO - NOTNLM
OT  - GFRalpha1
OT  - artemin
OT  - laryngeal squamous cell
OT  - survival
EDAT- 2014/08/15 06:00
MHDA- 2014/08/15 06:01
PMCR- 2014/07/02
CRDT- 2014/08/15 06:00
PHST- 2014/01/19 00:00 [received]
PHST- 2014/06/05 00:00 [accepted]
PHST- 2014/08/15 06:00 [entrez]
PHST- 2014/08/15 06:00 [pubmed]
PHST- 2014/08/15 06:01 [medline]
PHST- 2014/07/02 00:00 [pmc-release]
AID - etm-08-03-0818 [pii]
AID - 10.3892/etm.2014.1821 [doi]
PST - ppublish
SO  - Exp Ther Med. 2014 Sep;8(3):818-822. doi: 10.3892/etm.2014.1821. Epub 2014 Jul 2.