PMID- 25120819
OWN - NLM
STAT- MEDLINE
DCOM- 20150514
LR  - 20211021
IS  - 1936-2625 (Electronic)
IS  - 1936-2625 (Linking)
VI  - 7
IP  - 7
DP  - 2014
TI  - Associated liver enzymes with hyperlipidemic profile in type 2 diabetes patients.
PG  - 4345-9
AB  - Type 2 diabetes mellitus (T2DM) is characterized by hyperglycemia and is 
      associated with dyslipidemia and disturbed liver function. Aim of the present 
      work is to assess the liver enzymes and to find its association with 
      hyperlipidemic profile in T2DM. Total of 157 subjects were studied and divided 
      into two groups; diabetes (n=81) and non-diabetes (n=76). Various biochemical 
      parameters like fasting glucose, post prandial glucose, HbA1c, total cholesterol 
      (TC), triglycerides (Tg), high density lipoprotein cholesterol (HDL-C), alanine 
      amino transferase (ALT), aspartate amino transferase (AST) and gamma-glutamyl 
      transferase (GGT) were analyzed by ROCHE module Cobas 6000 (C501 & C601) 
      analyzer, kits were procured by ROCHE diagnostics. Low density lipoprotein 
      cholesterol (LDL-C) was estimated by Freidwald's formula. Statistical analysis 
      was performed by applying student t test and Pearson's correlation coefficient, 
      at 0.0001 and 0.05 level of significance, respectively. All the glycemic control 
      parameters, lipid profile parameters except HDL-C and liver enzymes were found 
      increased in diabetes group and significantly differ from non-diabetes group 
      (p>0.0001). ALT showed significant positive correlation with fasting glucose, 
      post prandial glucose, HbA1c, TC, Tg, LDL-C and GGT at p>0.05. AST showed very 
      weak relation with all parameters while GGT was positively associated with 
      fasting glucose, post prandial glucose, HbA1c, TC, Tg, LDL-C and ALT at p>0.05. 
      In conclusion, T2DM incline to elevate liver enzymes, especially ALT and GGT were 
      of significance. Routine screening of ALT and GGT in T2DM patients may assists 
      early detection of liver abnormalities and to arrest the progress of disease.
FAU - Al-Jameil, Noura
AU  - Al-Jameil N
AD  - Department of Clinical Laboratory Sciences, College of Applied Medical Sciences, 
      King Saud University Riyadh 11433, P. O. 10219, Saudi Arabia.
FAU - Khan, Farah A
AU  - Khan FA
AD  - Department of Clinical Laboratory Sciences, College of Applied Medical Sciences, 
      King Saud University Riyadh 11433, P. O. 10219, Saudi Arabia.
FAU - Arjumand, Sadia
AU  - Arjumand S
AD  - Department of Clinical Laboratory Sciences, College of Applied Medical Sciences, 
      King Saud University Riyadh 11433, P. O. 10219, Saudi Arabia.
FAU - Khan, Mohammad F
AU  - Khan MF
AD  - Department of Clinical Laboratory Sciences, College of Applied Medical Sciences, 
      King Saud University Riyadh 11433, P. O. 10219, Saudi Arabia.
FAU - Tabassum, Hajera
AU  - Tabassum H
AD  - Department of Clinical Laboratory Sciences, College of Applied Medical Sciences, 
      King Saud University Riyadh 11433, P. O. 10219, Saudi Arabia.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20140615
PL  - United States
TA  - Int J Clin Exp Pathol
JT  - International journal of clinical and experimental pathology
JID - 101480565
RN  - 0 (Blood Glucose)
RN  - EC 2.3.2.2 (gamma-Glutamyltransferase)
RN  - EC 2.6.1.1 (Aspartate Aminotransferases)
RN  - EC 2.6.1.2 (Alanine Transaminase)
SB  - IM
MH  - Adult
MH  - Aged
MH  - Aged, 80 and over
MH  - Alanine Transaminase/*metabolism
MH  - Aspartate Aminotransferases/*metabolism
MH  - Blood Glucose/analysis
MH  - Diabetes Mellitus, Type 2/*enzymology
MH  - Female
MH  - Humans
MH  - Hyperlipidemias/*enzymology
MH  - Male
MH  - Middle Aged
MH  - gamma-Glutamyltransferase/*metabolism
PMC - PMC4129054
OTO - NOTNLM
OT  - ALT
OT  - AST
OT  - Diabetes
OT  - GGT
OT  - dyslipidemia
EDAT- 2014/08/15 06:00
MHDA- 2015/05/15 06:00
PMCR- 2014/06/15
CRDT- 2014/08/15 06:00
PHST- 2014/05/11 00:00 [received]
PHST- 2014/06/25 00:00 [accepted]
PHST- 2014/08/15 06:00 [entrez]
PHST- 2014/08/15 06:00 [pubmed]
PHST- 2015/05/15 06:00 [medline]
PHST- 2014/06/15 00:00 [pmc-release]
PST - epublish
SO  - Int J Clin Exp Pathol. 2014 Jun 15;7(7):4345-9. eCollection 2014.