PMID- 25120836
OWN - NLM
STAT- MEDLINE
DCOM- 20150514
LR  - 20211021
IS  - 1936-2625 (Electronic)
IS  - 1936-2625 (Linking)
VI  - 7
IP  - 7
DP  - 2014
TI  - Mixed granular cell astrocytoma and fibrosarcoma of the brain: a case report.
PG  - 4473-8
AB  - We describe a rare primary mixed granular cell astrocytoma and fibrosarcoma 
      neoplasm, occurring in a 52-year-old female, with morphologic, 
      immunohistochemical and molecular genetic features, whose tumor was entirely 
      composed of granular cells and fibrosarcoma competent. This represents, to the 
      best of our knowledge, the first report of the mixed granular cell astrocytoma 
      and fibrosarcoma neoplasm. Moreover, two parts forming a complex arrangement that 
      excluded it being assessed as a coincidental collision tumor. We discuss the 
      relationship of two parts of this rare tumor by fluorescence in situ 
      hybridization (FISH). Sarcomatous components in this tumor had the same 
      aberrations of chromosomes to the gliomatous components of neoplasms, consisting 
      of 1p 19q loss and no evidence of PTEN allele loss and amplification of EGFR. It 
      was suggested that the sarcomatous component may be derived from glioma cells i 
      this case.
FAU - Yao, Kun
AU  - Yao K
AD  - Department of Pathology, Beijing San Bo Brain Hospital, Capital Medical 
      University Haidian District, Beijing, P. R. China.
FAU - Wang, Haixiang
AU  - Wang H
AD  - Beijing Key Laboratory of Epilepsy & Department of Neurology, Beijing San Bo 
      Brain Hospital, Capital Medical University Haidian District, Beijing, P. R. 
      China.
FAU - Duan, Zejun
AU  - Duan Z
AD  - Department of Pathology, Beijing San Bo Brain Hospital, Capital Medical 
      University Haidian District, Beijing, P. R. China.
FAU - Bian, Yu
AU  - Bian Y
AD  - Department of Pathology, Beijing San Bo Brain Hospital, Capital Medical 
      University Haidian District, Beijing, P. R. China.
FAU - Xia, Lei
AU  - Xia L
AD  - Department of Pathology, Beijing San Bo Brain Hospital, Capital Medical 
      University Haidian District, Beijing, P. R. China.
FAU - Ma, Zhong
AU  - Ma Z
AD  - Department of Pathology, Beijing San Bo Brain Hospital, Capital Medical 
      University Haidian District, Beijing, P. R. China.
FAU - Qi, Xueling
AU  - Qi X
AD  - Department of Pathology, Beijing San Bo Brain Hospital, Capital Medical 
      University Haidian District, Beijing, P. R. China.
LA  - eng
PT  - Case Reports
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20140615
PL  - United States
TA  - Int J Clin Exp Pathol
JT  - International journal of clinical and experimental pathology
JID - 101480565
SB  - IM
MH  - Astrocytoma/genetics/*pathology
MH  - Brain Neoplasms/genetics/*pathology
MH  - Female
MH  - Fibrosarcoma/genetics/*pathology
MH  - Humans
MH  - In Situ Hybridization, Fluorescence
MH  - Middle Aged
MH  - Neoplasms, Complex and Mixed/*pathology
PMC - PMC4129071
OTO - NOTNLM
OT  - 1p 19q loss
OT  - Granular cell astrocytoma
OT  - fibrosarcoma
EDAT- 2014/08/15 06:00
MHDA- 2015/05/15 06:00
PMCR- 2014/06/15
CRDT- 2014/08/15 06:00
PHST- 2014/04/30 00:00 [received]
PHST- 2014/06/23 00:00 [accepted]
PHST- 2014/08/15 06:00 [entrez]
PHST- 2014/08/15 06:00 [pubmed]
PHST- 2015/05/15 06:00 [medline]
PHST- 2014/06/15 00:00 [pmc-release]
PST - epublish
SO  - Int J Clin Exp Pathol. 2014 Jun 15;7(7):4473-8. eCollection 2014.