PMID- 25120969
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20140814
LR  - 20240321
IS  - 2249-782X (Print)
IS  - 0973-709X (Electronic)
IS  - 0973-709X (Linking)
VI  - 8
IP  - 6
DP  - 2014 Jun
TI  - Effect of age and Blood Pressure on Surrogate Markers of Atherosclerosis in 
      Patients with Type 2 Diabetes Mellitus.
PG  - BC08-11
LID - 10.7860/JCDR/2014/7859.4438 [doi]
AB  - BACKGROUND: Increased arterial stiffness may be an important path- way linking 
      diabetes mellitus to increased cardiovascular risk. AIM: The study was conducted 
      to assess the surrogate markers of arterial stiffness in patients with Type 2 
      diabetes mellitus (T2DM), and compare with age-matched hypertensive and healthy 
      controls. Also the effect of age and blood pressure on these markers was 
      evaluated. SETTINGS AND DESIGN: This cross-sectional study was carried out at a 
      tertiary care hospital in West India. METHODS: After a detailed medical history 
      and anthropometric evaluation, all the participants were subjected to 
      measurements of Arterial Stiffness Index (ASI), Pulse Wave Velocity (PWV), and 
      Augmentation Index (AIx) using a non-invasive oscillometric method. The four 
      study groups consisted of patients with T2DM (>5 years) along with hypertension, 
      newly diagnosed patients with T2DM (<2years) without hypertension, hypertensive 
      controls, and healthy controls. RESULTS: PWV, ASI, AIx were elevated in patients 
      with T2DM compared to healthy controls (p<0.05). Patients with T2DM above 60 
      years had higher carotid-femoral PWV, ASI and AIx than those below 60 years 
      (p<0.05). ASI and AIx were significantly increased in patients with T2DM with 
      hypertension having systolic BP > 140 mmHg compared to those with systolic BP < 
      140 mmHg. A very strong correlation between PWV and AIx in patients with T2DM and 
      hypertensive controls was observed. CONCLUSION: This study reveals that markers 
      of arterial stiffness (PWV, ASI, AIx) were increased significantly in patients 
      with T2DM compared to healthy controls. Age and systolic blood pressure had 
      significant influence on these markers. Thus, oscillometric markers have 
      potential utility in identifying subclinical atherosclerosis in patients with 
      T2DM.
FAU - Kulkarni, Namrata Bindurao
AU  - Kulkarni NB
AD  - PhD Student, Sir H.N. Medical Research Society, Sir H.N. Hospital & Research 
      Center , Rajaram Mohan Roy Road, Prarthana Samaj, Girgaum, Mumbai, India .
FAU - Ganu, Meghana Ulhas
AU  - Ganu MU
AD  - Clinical Assistant, Sir H.N. Medical Research Society, Sir H.N. Hospital & 
      Research Center , Rajaram Mohan Roy Road, Prarthana Samaj, Girgaum, Mumbai, India 
      .
FAU - Godbole, Sanjay Ganesh
AU  - Godbole SG
AD  - Consulting Physician, Sir H.N. Medical Research Society, Sir H.N. Hospital & 
      Research Center , Rajaram Mohan Roy Road, Prarthana Samaj, Girgaum, Mumbai, India 
      .
FAU - Deo, Sudha Srikant
AU  - Deo SS
AD  - Senior Research Scientist, Sir H.N. Medical Research Society, Sir H.N. Hospital & 
      Research Center , Rajaram Mohan Roy Road, Prarthana Samaj, Girgaum, Mumbai, India 
      .
LA  - eng
PT  - Journal Article
DEP - 20140620
PL  - India
TA  - J Clin Diagn Res
JT  - Journal of clinical and diagnostic research : JCDR
JID - 101488993
PMC - PMC4129315
OTO - NOTNLM
OT  - Arterial stiffness
OT  - Augmentation index
OT  - Pulse wave velocity
EDAT- 2014/08/15 06:00
MHDA- 2014/08/15 06:01
PMCR- 2014/08/01
CRDT- 2014/08/15 06:00
PHST- 2013/10/10 00:00 [received]
PHST- 2014/02/01 00:00 [accepted]
PHST- 2014/08/15 06:00 [entrez]
PHST- 2014/08/15 06:00 [pubmed]
PHST- 2014/08/15 06:01 [medline]
PHST- 2014/08/01 00:00 [pmc-release]
AID - 10.7860/JCDR/2014/7859.4438 [doi]
PST - ppublish
SO  - J Clin Diagn Res. 2014 Jun;8(6):BC08-11. doi: 10.7860/JCDR/2014/7859.4438. Epub 
      2014 Jun 20.