PMID- 25121131
OWN - NLM
STAT- MEDLINE
DCOM- 20150420
LR  - 20221207
IS  - 1537-744X (Electronic)
IS  - 2356-6140 (Print)
IS  - 1537-744X (Linking)
VI  - 2014
DP  - 2014
TI  - Sequence variants of ADIPOQ and association with type 2 diabetes mellitus in 
      Taiwan Chinese Han population.
PG  - 650393
LID - 10.1155/2014/650393 [doi]
LID - 650393
AB  - Diabetes is a serious global health problem. Large-scale genome-wide association 
      studies identified loci for type 2 diabetes mellitus (T2DM), including 
      adiponectin (ADIPOQ) gene and transcription factor 7-like 2 (TCF7L2), but few 
      studies clarified the effect of genetic polymorphisms of ADIPOQ and TCF7L2 on 
      risk of T2DM. We attempted to elucidate association between T2DM and polymorphic 
      variations of both in Taiwan's Chinese Han population, with our retrospective 
      case-control study genotyping single nucleotide polymorphisms (SNPs) in ADIPOQ 
      and TCF7L2 genes both in 149 T2DM patients and in 139 healthy controls from 
      Taiwan. Statistical analysis gauged association of these polymorphisms with risk 
      of T2DM to show ADIPOQ rs1501299 polymorphism variations strongly correlated with 
      T2DM risk (P = 0.042), with rs2241766 polymorphism being not associated with T2DM 
      (P = 0.967). However, both polymorphisms rs7903146 and rs12255372 of TCF7L2 were 
      rarely detected in Taiwanese people. This study avers that ADIPOQ rs1501299 
      polymorphism contributes to risk of T2DM in the Taiwanese population.
FAU - Tsai, Ming-Kai
AU  - Tsai MK
AD  - Division of Nephrology, Department of Medicine, Kaohsiung Armed Forces General 
      Hospital, Kaohsiung 80284, Taiwan.
FAU - Wang, Hui-Min David
AU  - Wang HM
AD  - Department of Fragrance and Cosmetic Science, Kaohsiung Medical University, 
      Kaohsiung 80708, Taiwan ; Graduate Institute of Natural Products, Kaohsiung 
      Medical University, Kaohsiung 80708, Taiwan.
FAU - Shiang, Jeng-Chuan
AU  - Shiang JC
AD  - Division of Nephrology, Department of Medicine, Kaohsiung Armed Forces General 
      Hospital, Kaohsiung 80284, Taiwan.
FAU - Chen, I-Hung
AU  - Chen IH
AD  - Division of Nephrology, Department of Medicine, Kaohsiung Armed Forces General 
      Hospital, Kaohsiung 80284, Taiwan.
FAU - Wang, Chih-Chiang
AU  - Wang CC
AD  - Division of Nephrology, Department of Medicine, Kaohsiung Armed Forces General 
      Hospital, Kaohsiung 80284, Taiwan.
FAU - Shiao, Ya-Fen
AU  - Shiao YF
AD  - Asia-Pacific Biotech Developing, Inc., Kaohsiung 80681, Taiwan.
FAU - Liu, Wen-Sheng
AU  - Liu WS
AD  - Asia-Pacific Biotech Developing, Inc., Kaohsiung 80681, Taiwan.
FAU - Lin, Tai-Jung
AU  - Lin TJ
AD  - Department of Pharmacy and Graduate Institute of Pharmaceutical Technology, Tajen 
      University, Pingtung 90741, Taiwan.
FAU - Chen, Tsung-Ming
AU  - Chen TM
AD  - Department of Physiology, College of Medicine, National Cheng Kung University, 1 
      University Road, Tainan 70101, Taiwan ; Department and Graduate Institute of 
      Aquaculture, National Kaohsiung Marine University, Kaohsiung 81157, Taiwan.
FAU - Chen, Ya-Huey
AU  - Chen YH
AD  - Center for Molecular Medicine, China Medical University Hospital, Taichung 40477, 
      Taiwan ; Graduate Institute of Cancer Biology, China Medical University, Cancer 
      Center Building 8F, No. 6 Hsueh-Shih Road, Taichung 40477, Taiwan.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20140710
PL  - United States
TA  - ScientificWorldJournal
JT  - TheScientificWorldJournal
JID - 101131163
RN  - 0 (ADIPOQ protein, human)
RN  - 0 (Adiponectin)
RN  - 0 (TCF7L2 protein, human)
RN  - 0 (Transcription Factor 7-Like 2 Protein)
SB  - IM
MH  - Adiponectin/*genetics
MH  - Asian People/*genetics
MH  - Diabetes Mellitus, Type 2/*genetics
MH  - Genome-Wide Association Study
MH  - Humans
MH  - Odds Ratio
MH  - Polymorphism, Single Nucleotide/genetics
MH  - Retrospective Studies
MH  - Taiwan
MH  - Transcription Factor 7-Like 2 Protein/genetics
PMC - PMC4121223
EDAT- 2014/08/15 06:00
MHDA- 2015/04/22 06:00
PMCR- 2014/07/10
CRDT- 2014/08/15 06:00
PHST- 2014/03/18 00:00 [received]
PHST- 2014/06/04 00:00 [revised]
PHST- 2014/06/16 00:00 [accepted]
PHST- 2014/08/15 06:00 [entrez]
PHST- 2014/08/15 06:00 [pubmed]
PHST- 2015/04/22 06:00 [medline]
PHST- 2014/07/10 00:00 [pmc-release]
AID - 10.1155/2014/650393 [doi]
PST - ppublish
SO  - ScientificWorldJournal. 2014;2014:650393. doi: 10.1155/2014/650393. Epub 2014 Jul 
      10.