PMID- 25123603
OWN - NLM
STAT- MEDLINE
DCOM- 20160125
LR  - 20181202
IS  - 1876-4738 (Electronic)
IS  - 0914-5087 (Linking)
VI  - 65
IP  - 5
DP  - 2015 May
TI  - Predictive value of apoptotic microparticles to mononuclear progenitor cells 
      ratio in advanced chronic heart failure patients.
PG  - 403-11
LID - S0914-5087(14)00200-7 [pii]
LID - 10.1016/j.jjcc.2014.06.014 [doi]
AB  - BACKGROUND: Acutely decompensated chronic heart failure (ADHF) is considered a 
      life-threatening event. Despite contemporary treatment strategies of ADHF, 
      frequent recurrent hospitalizations due to other cardiovascular reasons after 
      discharge of patients from hospital occur. The objective of the study was to 
      examine the prognostic value of circulating endothelial-derived apoptotic 
      microparticles (EMPs) to mononuclear progenitor cells (MPCs) ratio for 
      post-discharge patients with clinical stabilization after ischemic ADHF. METHODS: 
      We consecutively enrolled 136 patients (62 male) with coronary artery disease 
      (CAD) admitted with a primary diagnosis of ADHF. All patients gave written 
      informed consent for participation in the study. At baseline, all enrolled 
      patients were hemodynamically stable and they had New York Heart Association 
      (NYHA) III/IV classes of ischemic chronic heart failure (CHF). Observation period 
      started at discharge from the hospital and was up to 3 years. Flow cytometry 
      analysis for quantifying the number of EMPs and angiogenic MPCs was used. 
      RESULTS: Calculated EMP to MPC ratios in survivor and dead patient cohort were 
      8.4 (95% CI=7.6-9.2) and 78.9 (95% CI=53.0-116.6), respectively (p=0.001). MPCs, 
      EMPs, NYHA class, N-terminal pro-brain natriuretic peptide (NT-proBNP) and 
      increased NT-proBNP>30% within 24-84h of admission period remained statistically 
      significant for all-cause mortality, CHF-related death, and CHF-related 
      rehospitalization, whereas left ventricular ejection fraction and 
      high-sensitivity C-reactive protein for all variables did not. We found that the 
      addition of EPMs to MPCs ratio to the ABC model (NT-pro-BNP, increased 
      NT-pro-BNP>30%) improved the relative integrated discrimination indices by 19.6% 
      for all-cause mortality, by 21.7% for CHF-related death, and by 19.5% for 
      CHF-related rehospitalization. CONCLUSION: We demonstrated that EMP to MPC ratio 
      is considered an important indicator of an imbalance between angiogenic and 
      apoptotic responses with possible relation to cardiovascular outcomes in 
      post-discharge patients with clinical stabilization after ischemic ADHF.
CI  - Copyright (c) 2014 Japanese College of Cardiology. Published by Elsevier Ltd. All 
      rights reserved.
FAU - Berezin, Alexander E
AU  - Berezin AE
AD  - Internal Medicine Department, State Medical University, Zaporozhye, Ukraine. 
      Electronic address: dr_berezin@mail.ru.
FAU - Kremzer, Alexander A
AU  - Kremzer AA
AD  - State Medical University, Clinical Pharmacology Department, Zaporozhye, Ukraine.
FAU - Samura, Tatyana A
AU  - Samura TA
AD  - State Medical University, Clinical Pharmacology Department, Zaporozhye, Ukraine.
FAU - Martovitskaya, Yulia V
AU  - Martovitskaya YV
AD  - State Medical University, Pathology Department, Zaporozhye, Ukraine.
FAU - Malinovskiy, Yaroslav V
AU  - Malinovskiy YV
AD  - Regional Cardiology Center, Zaporozhye, Ukraine.
FAU - Oleshko, Sergey V
AU  - Oleshko SV
AD  - Regional Cardiology Center, Zaporozhye, Ukraine.
FAU - Berezina, Tatyana A
AU  - Berezina TA
AD  - Private Medical Center "Vitacenter", Zaporozhye, Ukraine.
LA  - eng
PT  - Journal Article
DEP - 20140807
PL  - Netherlands
TA  - J Cardiol
JT  - Journal of cardiology
JID - 8804703
RN  - 0 (Biomarkers)
RN  - 0 (Peptide Fragments)
RN  - 0 (pro-brain natriuretic peptide (1-76))
RN  - 114471-18-0 (Natriuretic Peptide, Brain)
SB  - IM
MH  - Aged
MH  - *Apoptosis
MH  - Biomarkers/blood
MH  - Cell-Derived Microparticles/*pathology
MH  - Chronic Disease
MH  - Female
MH  - Heart Failure/blood/*classification/*diagnosis
MH  - Humans
MH  - Kaplan-Meier Estimate
MH  - Male
MH  - Middle Aged
MH  - Models, Cardiovascular
MH  - Natriuretic Peptide, Brain/blood
MH  - Peptide Fragments/blood
MH  - Predictive Value of Tests
MH  - Prognosis
MH  - Retrospective Studies
MH  - Severity of Illness Index
MH  - Stem Cells/*pathology
OTO - NOTNLM
OT  - Advanced chronic heart failure
OT  - Endothelial-derived apoptotic microparticles
OT  - Proangiogenic mononuclear cells
OT  - Prognosis
EDAT- 2014/08/16 06:00
MHDA- 2016/01/26 06:00
CRDT- 2014/08/16 06:00
PHST- 2014/05/14 00:00 [received]
PHST- 2014/06/19 00:00 [revised]
PHST- 2014/06/25 00:00 [accepted]
PHST- 2014/08/16 06:00 [entrez]
PHST- 2014/08/16 06:00 [pubmed]
PHST- 2016/01/26 06:00 [medline]
AID - S0914-5087(14)00200-7 [pii]
AID - 10.1016/j.jjcc.2014.06.014 [doi]
PST - ppublish
SO  - J Cardiol. 2015 May;65(5):403-11. doi: 10.1016/j.jjcc.2014.06.014. Epub 2014 Aug 
      7.