PMID- 25123850
OWN - NLM
STAT- MEDLINE
DCOM- 20150714
LR  - 20140815
IS  - 1651-2251 (Electronic)
IS  - 0001-6489 (Linking)
VI  - 134
IP  - 9
DP  - 2014 Sep
TI  - Up-regulated expression of Dicer reveals poor prognosis in laryngeal squamous 
      cell carcinoma.
PG  - 959-63
LID - 10.3109/00016489.2014.920962 [doi]
AB  - CONCLUSIONS: Increased expression of Dicer may be a prognostic biomarker for 
      patients with laryngeal squamous cell carcinoma (LSCC). OBJECTIVES: Recent 
      studies have shown that many microRNAs (miRNAs) play an important role in the 
      development and progression of human cancers. Dicer, one of the most important 
      enzymes of the miRNA machinery, performs the final step of biogenesis of miRNAs. 
      This study aimed to investigate the impact of Dicer expression on patient 
      survival in human LSCC. METHODS: We detected the expression of Dicer in larynx 
      tissue specimens from 76 LSCC samples and 26 polyps by immunohistochemistry. The 
      clinicopathological and prognostic significance of Dicer expression was 
      investigated in LSCC. RESULTS: Our data showed that the expression of Dicer was 
      significantly higher in the LSCC than in the polyp tissue specimens. Moreover, 
      the expression level of Dicer was significantly associated with the pTNM stage 
      and tumor lymph node metastasis. Kaplan-Meier survival analyses revealed a strong 
      association between tumor Dicer expression and the survival of the patients with 
      LSCC.
FAU - Gao, Chaobing
AU  - Gao C
AD  - Department of Otorhinolaryngology, Head and Neck Surgery, First Affiliated 
      Hospital of AnHui Medical University , Hefei , China.
FAU - Li, Xiaohong
AU  - Li X
FAU - Tong, Busheng
AU  - Tong B
FAU - Wu, Kaile
AU  - Wu K
FAU - Liu, Yehai
AU  - Liu Y
FAU - Anniko, Matti
AU  - Anniko M
FAU - Duan, Maoli
AU  - Duan M
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - England
TA  - Acta Otolaryngol
JT  - Acta oto-laryngologica
JID - 0370354
RN  - EC 3.1.26.3 (DICER1 protein, human)
RN  - EC 3.1.26.3 (Ribonuclease III)
RN  - EC 3.6.4.13 (DEAD-box RNA Helicases)
SB  - IM
MH  - Carcinoma, Squamous Cell/*metabolism/mortality/pathology
MH  - China/epidemiology
MH  - DEAD-box RNA Helicases/*metabolism
MH  - Female
MH  - Humans
MH  - Laryngeal Neoplasms/*metabolism/mortality/pathology
MH  - Male
MH  - Middle Aged
MH  - Prognosis
MH  - Retrospective Studies
MH  - Ribonuclease III/*metabolism
MH  - Up-Regulation
OTO - NOTNLM
OT  - Larynx
OT  - biomarker
OT  - cancer
OT  - metastasis
EDAT- 2014/08/16 06:00
MHDA- 2015/07/15 06:00
CRDT- 2014/08/16 06:00
PHST- 2014/08/16 06:00 [entrez]
PHST- 2014/08/16 06:00 [pubmed]
PHST- 2015/07/15 06:00 [medline]
AID - 10.3109/00016489.2014.920962 [doi]
PST - ppublish
SO  - Acta Otolaryngol. 2014 Sep;134(9):959-63. doi: 10.3109/00016489.2014.920962.