PMID- 25124374
OWN - NLM
STAT- MEDLINE
DCOM- 20150821
LR  - 20200106
IS  - 1873-474X (Electronic)
IS  - 0736-5748 (Linking)
VI  - 38
DP  - 2014 Nov
TI  - Developmental and degenerative modulation of brain-derived neurotrophic factor 
      transcript variants in the mouse hippocampus.
PG  - 68-73
LID - S0736-5748(14)00131-2 [pii]
LID - 10.1016/j.ijdevneu.2014.08.001 [doi]
AB  - Brain-derived neurotrophic factor (BDNF) is regarded as an important factor for 
      neurogenesis, synaptic plasticity, and neuronal network organization in brain 
      circuits. However, little is known about the regulation of BDNF transcript 
      variants in the hippocampus during postnatal development and following chemically 
      induced neurotoxicity. In the present study, we examined the expression of 
      individual BDNF transcript variants in the mouse hippocampus on postnatal day 
      (PD) 3, 7, 14, 21, and 56, as well as in the adult hippocampus 1, 2, 4, and 8 
      days after trimethyltin (TMT) treatment. During postnatal development, the 
      expression levels of common BDNF-coding transcripts and BDNF transcript variants 
      increased gradually in the hippocampus, but the temporal patterns of each exon 
      transcript showed significant differences. In the TMT-treated hippocampus, the 
      levels of common BDNF-coding transcripts and exon I, IIC, III, VII, VIII, and IXA 
      transcripts were significantly increased 1 day post-treatment. These observations 
      suggest that the differential regulation of BDNF exon transcripts may be 
      associated with neuronal and synaptic maturation during postnatal development, 
      and neuronal survival and synaptic plasticity in chemically induced 
      neurodegeneration.
CI  - Copyright (c) 2014 ISDN. Published by Elsevier Ltd. All rights reserved.
FAU - Kim, Jinwook
AU  - Kim J
AD  - College of Veterinary Medicine and Animal Medical Institute, Chonnam National 
      University, Gwangju 500-757, South Korea.
FAU - Yang, Miyoung
AU  - Yang M
AD  - Department of Physiology and Neuroscience Program, Michigan State University, 
      East Lansing, MI 48824, USA.
FAU - Kim, Juhwan
AU  - Kim J
AD  - College of Veterinary Medicine and Animal Medical Institute, Chonnam National 
      University, Gwangju 500-757, South Korea.
FAU - Song, Lina
AU  - Song L
AD  - College of Veterinary Medicine and Animal Medical Institute, Chonnam National 
      University, Gwangju 500-757, South Korea.
FAU - Lee, Sueun
AU  - Lee S
AD  - College of Veterinary Medicine and Animal Medical Institute, Chonnam National 
      University, Gwangju 500-757, South Korea.
FAU - Son, Yeonghoon
AU  - Son Y
AD  - College of Veterinary Medicine and Animal Medical Institute, Chonnam National 
      University, Gwangju 500-757, South Korea.
FAU - Kang, Sohi
AU  - Kang S
AD  - College of Veterinary Medicine and Animal Medical Institute, Chonnam National 
      University, Gwangju 500-757, South Korea.
FAU - Bae, Chun-Sik
AU  - Bae CS
AD  - College of Veterinary Medicine and Animal Medical Institute, Chonnam National 
      University, Gwangju 500-757, South Korea.
FAU - Kim, Jong-Choon
AU  - Kim JC
AD  - College of Veterinary Medicine and Animal Medical Institute, Chonnam National 
      University, Gwangju 500-757, South Korea.
FAU - Kim, Sung-Ho
AU  - Kim SH
AD  - College of Veterinary Medicine and Animal Medical Institute, Chonnam National 
      University, Gwangju 500-757, South Korea.
FAU - Shin, Taekyun
AU  - Shin T
AD  - College of Veterinary Medicine, Jeju National University, Jeju 690-756, South 
      Korea.
FAU - Wang, Hongbing
AU  - Wang H
AD  - Department of Physiology and Neuroscience Program, Michigan State University, 
      East Lansing, MI 48824, USA.
FAU - Moon, Changjong
AU  - Moon C
AD  - College of Veterinary Medicine and Animal Medical Institute, Chonnam National 
      University, Gwangju 500-757, South Korea. Electronic address: 
      moonc@chonnam.ac.kr.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20140811
PL  - United States
TA  - Int J Dev Neurosci
JT  - International journal of developmental neuroscience : the official journal of the 
      International Society for Developmental Neuroscience
JID - 8401784
RN  - 0 (Brain-Derived Neurotrophic Factor)
RN  - 0 (Trimethyltin Compounds)
RN  - 0 (brain-derived growth factor)
RN  - 1631-73-8 (trimethyltin)
SB  - IM
MH  - Age Factors
MH  - Animals
MH  - Animals, Newborn
MH  - Brain-Derived Neurotrophic Factor/*genetics/*metabolism
MH  - Developmental Disabilities/etiology/*pathology
MH  - Disease Models, Animal
MH  - Exons/drug effects
MH  - Female
MH  - Gene Expression Regulation, Developmental/drug effects/*physiology
MH  - Hippocampus/*metabolism
MH  - Male
MH  - Mice
MH  - Mice, Inbred C57BL
MH  - Nerve Degeneration/etiology/*pathology
MH  - Neurotoxicity Syndromes/complications/etiology
MH  - Pregnancy
MH  - Seizures/chemically induced
MH  - Time Factors
MH  - Trimethyltin Compounds/toxicity
OTO - NOTNLM
OT  - BDNF
OT  - Exon
OT  - Hippocampus
OT  - Postnatal development
OT  - Trimethyltin
EDAT- 2014/08/16 06:00
MHDA- 2015/08/22 06:00
CRDT- 2014/08/16 06:00
PHST- 2014/04/22 00:00 [received]
PHST- 2014/08/01 00:00 [revised]
PHST- 2014/08/03 00:00 [accepted]
PHST- 2014/08/16 06:00 [entrez]
PHST- 2014/08/16 06:00 [pubmed]
PHST- 2015/08/22 06:00 [medline]
AID - S0736-5748(14)00131-2 [pii]
AID - 10.1016/j.ijdevneu.2014.08.001 [doi]
PST - ppublish
SO  - Int J Dev Neurosci. 2014 Nov;38:68-73. doi: 10.1016/j.ijdevneu.2014.08.001. Epub 
      2014 Aug 11.