PMID- 25125137
OWN - NLM
STAT- MEDLINE
DCOM- 20160208
LR  - 20220410
IS  - 1096-0023 (Electronic)
IS  - 1043-4666 (Linking)
VI  - 70
IP  - 2
DP  - 2014 Dec
TI  - Association between TNF-alpha-308 G/A gene polymorphism and gastric cancer risk: a 
      systematic review and meta-analysis.
PG  - 104-14
LID - S1043-4666(14)00215-4 [pii]
LID - 10.1016/j.cyto.2014.07.005 [doi]
AB  - OBJECTIVE: Tumor necrosis factor-alpha (TNF-alpha) has been found to be associated 
      with gastric carcinogenesis, but individually published results have been 
      inconclusive. The aim of this study was to explore the relationship between the 
      TNF-alpha-308 G/A polymorphism and gastric cancer risk. METHODS: MEDLINE, EMBASE and 
      the COCHRANE library databases were searched for relevant articles to identify 
      all available data. The odds ratios (ORs) with 95% confidence intervals (95% CIs) 
      from each study were used to assess the association between the TNF-alpha-308 G/A 
      polymorphism and gastric cancer risk. RESULTS: This meta-analysis included 30 
      studies (32 datasets) involving 7009 gastric cancer cases and 12,119 control 
      subjects. Overall, a significant association was found between the TNF-alpha-308 G/A 
      polymorphism and gastric cancer in AA+GA vs. GG (dominant contrast model) 
      (OR=1.20, 95% CI=1.07-1.34, p=0.001). With stratification based on ethnicity, the 
      TNF-alpha-308 G/A polymorphism was correlated with gastric cancer risk in Caucasians, 
      using the dominant contrast model (OR=0.74, 95% CI=0.57-0.96, p=0.02), but not in 
      East Asians and other ethnic groups. In the comprehensive subgroup analysis, a 
      significant association was also found in recent articles (published after 2005), 
      population-based high-quality studies, hospital-based high-quality studies, 
      studies using the TaqMan method and non-cardia subgroups. However, the TNF-alpha-308 
      G/A polymorphism was not associated with specific histological types of gastric 
      cancer risk. CONCLUSIONS: The TNF-alpha-308 G/A polymorphism may contribute to 
      susceptibility to gastric cancer in Caucasians, especially for non-cardia gastric 
      cancer, as most strongly demonstrated in high-quality studies and in studies 
      using the TaqMan genotyping method. Furthermore, we recommend the TaqMan method 
      as the preferred genotyping method in DNA polymorphism studies.
CI  - Copyright (c) 2014 Elsevier Ltd. All rights reserved.
FAU - Yang, Jong-Pill
AU  - Yang JP
AD  - Division of Upper Gastrointestinal Surgery, Department of Surgery, Korea 
      University Anam Hospital, Korea University College of Medicine, Seoul, Republic 
      of Korea.
FAU - Hyun, Myung-Han
AU  - Hyun MH
AD  - Division of Upper Gastrointestinal Surgery, Department of Surgery, Korea 
      University Anam Hospital, Korea University College of Medicine, Seoul, Republic 
      of Korea.
FAU - Yoon, Jeong-Min
AU  - Yoon JM
AD  - Division of Upper Gastrointestinal Surgery, Department of Surgery, Korea 
      University Anam Hospital, Korea University College of Medicine, Seoul, Republic 
      of Korea.
FAU - Park, Min-Jeong
AU  - Park MJ
AD  - Division of Upper Gastrointestinal Surgery, Department of Surgery, Korea 
      University Anam Hospital, Korea University College of Medicine, Seoul, Republic 
      of Korea.
FAU - Kim, Donghyeok
AU  - Kim D
AD  - Division of Upper Gastrointestinal Surgery, Department of Surgery, Korea 
      University Anam Hospital, Korea University College of Medicine, Seoul, Republic 
      of Korea.
FAU - Park, Sungsoo
AU  - Park S
AD  - Division of Upper Gastrointestinal Surgery, Department of Surgery, Korea 
      University Anam Hospital, Korea University College of Medicine, Seoul, Republic 
      of Korea. Electronic address: kugspss@korea.ac.kr.
LA  - eng
PT  - Journal Article
PT  - Meta-Analysis
PT  - Review
PT  - Systematic Review
DEP - 20140812
PL  - England
TA  - Cytokine
JT  - Cytokine
JID - 9005353
RN  - 0 (Tumor Necrosis Factor-alpha)
SB  - IM
MH  - Ethnicity/genetics
MH  - *Genetic Association Studies
MH  - Genetic Heterogeneity
MH  - *Genetic Predisposition to Disease
MH  - Humans
MH  - Polymorphism, Single Nucleotide/*genetics
MH  - Publication Bias
MH  - Risk Factors
MH  - Stomach Neoplasms/*genetics
MH  - Tumor Necrosis Factor-alpha/*genetics
OTO - NOTNLM
OT  - Cytokine
OT  - Gastric cancer
OT  - Polymorphism
OT  - TNF-alpha-308
OT  - Tumor necrosis factor-alpha
EDAT- 2014/08/16 06:00
MHDA- 2016/02/09 06:00
CRDT- 2014/08/16 06:00
PHST- 2014/01/18 00:00 [received]
PHST- 2014/06/18 00:00 [revised]
PHST- 2014/07/14 00:00 [accepted]
PHST- 2014/08/16 06:00 [entrez]
PHST- 2014/08/16 06:00 [pubmed]
PHST- 2016/02/09 06:00 [medline]
AID - S1043-4666(14)00215-4 [pii]
AID - 10.1016/j.cyto.2014.07.005 [doi]
PST - ppublish
SO  - Cytokine. 2014 Dec;70(2):104-14. doi: 10.1016/j.cyto.2014.07.005. Epub 2014 Aug 
      12.