PMID- 25125149
OWN - NLM
STAT- MEDLINE
DCOM- 20151116
LR  - 20191210
IS  - 1556-4029 (Electronic)
IS  - 0022-1198 (Linking)
VI  - 60
IP  - 1
DP  - 2015 Jan
TI  - The variability of ecstasy tablets composition in Brazil.
PG  - 147-51
LID - 10.1111/1556-4029.12584 [doi]
AB  - The content of ecstasy tablets has been changing over the years, and nowadays 
      3,4-methylenedioxymethamphetamine (MDMA) is not always present in the tablets. 
      The aim of this study was to investigate the chemical composition in the seized 
      tablets labeled as ecstasy. We analyzed samples from 150 different seizures made 
      by Sao Paulo's State Police by gas chromatography-mass spectrometry. MDMA was 
      present in 44.7% of the analyzed samples, and another twenty different active 
      substances were identified in these tablets, such as caffeine, 2C-B, piperazines, 
      amphetamines, phencyclidine, and others. Methamphetamine was present in 22% of 
      these samples. The results demonstrate a huge shift in the pattern of trafficking 
      of synthetic drugs, where MDMA has been replaced in tablets mostly by illicit 
      psychoactive substances, in a clear attempt to bypass the law. The great 
      variability in the tablets composition may lead to an increased risk of drug 
      poisoning.
CI  - (c) 2014 American Academy of Forensic Sciences.
FAU - Togni, Loraine R
AU  - Togni LR
AD  - Forensic Toxicology and Chemistry Laboratory, Criminalistic Institute of Sao 
      Paulo, Sao Paulo, SP, 05507-060, Brazil.
FAU - Lanaro, Rafael
AU  - Lanaro R
FAU - Resende, Rodrigo R
AU  - Resende RR
FAU - Costa, Jose L
AU  - Costa JL
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20140814
PL  - United States
TA  - J Forensic Sci
JT  - Journal of forensic sciences
JID - 0375370
RN  - 0 (Hallucinogens)
RN  - 0 (Illicit Drugs)
RN  - KE1SEN21RM (N-Methyl-3,4-methylenedioxyamphetamine)
SB  - IM
MH  - Brazil
MH  - *Drug Contamination
MH  - Gas Chromatography-Mass Spectrometry
MH  - Hallucinogens/*chemistry
MH  - Humans
MH  - Illicit Drugs/*chemistry
MH  - Legislation, Drug
MH  - N-Methyl-3,4-methylenedioxyamphetamine/*chemistry
OTO - NOTNLM
OT  - MDMA
OT  - chemical profiling
OT  - designer drugs
OT  - ecstasy
OT  - forensic science
OT  - gas chromatography-mass spectrometry
EDAT- 2014/08/16 06:00
MHDA- 2015/11/17 06:00
CRDT- 2014/08/16 06:00
PHST- 2013/02/23 00:00 [received]
PHST- 2013/11/26 00:00 [revised]
PHST- 2013/12/07 00:00 [accepted]
PHST- 2014/08/16 06:00 [entrez]
PHST- 2014/08/16 06:00 [pubmed]
PHST- 2015/11/17 06:00 [medline]
AID - 10.1111/1556-4029.12584 [doi]
PST - ppublish
SO  - J Forensic Sci. 2015 Jan;60(1):147-51. doi: 10.1111/1556-4029.12584. Epub 2014 
      Aug 14.