PMID- 25125238
OWN - NLM
STAT- MEDLINE
DCOM- 20150526
LR  - 20191210
IS  - 1872-7549 (Electronic)
IS  - 0166-4328 (Linking)
VI  - 274
DP  - 2014 Nov 1
TI  - BDNF val66met genotype and schizotypal personality traits interact to influence 
      probabilistic association learning.
PG  - 137-42
LID - S0166-4328(14)00490-2 [pii]
LID - 10.1016/j.bbr.2014.07.041 [doi]
AB  - The brain derived neurotrophic factor (BDNF) val66met polymorphism rs6265 
      influences learning and may represent a risk factor for schizophrenia. Healthy 
      people with high schizotypal personality traits display cognitive deficits that 
      are similar to but not as severe as those observed in schizophrenia and they can 
      be studied without confounds of antipsychotics or chronic illness. How genetic 
      variation in BDNF may impact learning in individuals falling along the 
      schizophrenia spectrum is unknown. We predicted that schizotypal personality 
      traits would influence learning and that schizotypal personality-based 
      differences in learning would vary depending on the BDNF val66met genotype. 
      Eighty-nine healthy adults completed the Schizotypal Personality Questionnaire 
      (SPQ) and a probabilistic association learning test. Blood samples were genotyped 
      for the BDNF val66met polymorphism. An ANOVA was performed with BDNF genotype 
      (val homozygotes and met-carriers) and SPQ score (high/low) as grouping variables 
      and probabilistic association learning as the dependent variable. Participants 
      with low SPQ scores (fewer schizotypal personality traits) showed significantly 
      better learning than those with high SPQ scores. BDNF met-carriers displaying few 
      schizotypal personality traits performed best, whereas BDNF met-carriers 
      displaying high schizotypal personality traits performed worst. Thus, the BDNF 
      val66met polymorphism appears to influence probabilistic association learning 
      differently depending on the extent of schizotypal personality traits displayed.
CI  - Crown Copyright (c) 2014. Published by Elsevier B.V. All rights reserved.
FAU - Skilleter, Ashley Jayne
AU  - Skilleter AJ
AD  - School of Psychiatry, University of New South Wales, Randwick, NSW, Australia; 
      Schizophrenia Research Institute, Darlinghurst, NSW, Australia; Neuroscience 
      Research Australia, Randwick, NSW, Australia.
FAU - Weickert, Cynthia Shannon
AU  - Weickert CS
AD  - School of Psychiatry, University of New South Wales, Randwick, NSW, Australia; 
      Schizophrenia Research Institute, Darlinghurst, NSW, Australia; Neuroscience 
      Research Australia, Randwick, NSW, Australia.
FAU - Moustafa, Ahmed Abdelhalim
AU  - Moustafa AA
AD  - School of Social Sciences and Psychology, Marcs Institute for Brain and 
      Behaviour, University of Western Sydney, Penrith, NSW, Australia.
FAU - Gendy, Rasha
AU  - Gendy R
AD  - School of Medicine, University of New South Wales, Randwick, NSW, Australia.
FAU - Chan, Mico
AU  - Chan M
AD  - School of Medicine, University of New South Wales, Randwick, NSW, Australia.
FAU - Arifin, Nur
AU  - Arifin N
AD  - School of Medicine, University of New South Wales, Randwick, NSW, Australia.
FAU - Mitchell, Philip Bowden
AU  - Mitchell PB
AD  - School of Psychiatry, University of New South Wales, Randwick, NSW, Australia; 
      Black Dog Institute, Randwick, NSW, Australia.
FAU - Weickert, Thomas Wesley
AU  - Weickert TW
AD  - School of Psychiatry, University of New South Wales, Randwick, NSW, Australia; 
      Schizophrenia Research Institute, Darlinghurst, NSW, Australia; Neuroscience 
      Research Australia, Randwick, NSW, Australia. Electronic address: 
      t.weickert@unsw.edu.au.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20140811
PL  - Netherlands
TA  - Behav Brain Res
JT  - Behavioural brain research
JID - 8004872
RN  - 0 (Brain-Derived Neurotrophic Factor)
RN  - AE28F7PNPL (Methionine)
RN  - HG18B9YRS7 (Valine)
SB  - IM
MH  - Analysis of Variance
MH  - Association Learning/*physiology
MH  - Brain-Derived Neurotrophic Factor/*genetics
MH  - Female
MH  - Genotype
MH  - Humans
MH  - Learning Disabilities/*etiology
MH  - Male
MH  - Methionine/genetics
MH  - Polymorphism, Single Nucleotide/*genetics
MH  - Probability Learning
MH  - Psychiatric Status Rating Scales
MH  - Schizotypal Personality Disorder/*complications/*genetics
MH  - Valine/genetics
MH  - Young Adult
OTO - NOTNLM
OT  - Brain derived neurotrophic factor val66met polymorphism
OT  - Probabilistic association learning
OT  - Schizotypal personality
EDAT- 2014/08/16 06:00
MHDA- 2015/05/27 06:00
CRDT- 2014/08/16 06:00
PHST- 2014/03/17 00:00 [received]
PHST- 2014/07/24 00:00 [revised]
PHST- 2014/07/27 00:00 [accepted]
PHST- 2014/08/16 06:00 [entrez]
PHST- 2014/08/16 06:00 [pubmed]
PHST- 2015/05/27 06:00 [medline]
AID - S0166-4328(14)00490-2 [pii]
AID - 10.1016/j.bbr.2014.07.041 [doi]
PST - ppublish
SO  - Behav Brain Res. 2014 Nov 1;274:137-42. doi: 10.1016/j.bbr.2014.07.041. Epub 2014 
      Aug 11.