PMID- 25125625
OWN - NLM
STAT- MEDLINE
DCOM- 20141017
LR  - 20150813
IS  - 1943-7722 (Electronic)
IS  - 0002-9173 (Linking)
VI  - 142
IP  - 3
DP  - 2014 Sep
TI  - Aberrations of MYC are a common event in B-cell prolymphocytic leukemia.
PG  - 347-54
LID - 10.1309/AJCPUBHM8U7ZFLOB [doi]
AB  - OBJECTIVES: B-cell prolymphocytic leukemia (B-PLL) remains a controversial 
      entity, and its molecular pathogenesis is largely unknown. Patients are older, 
      typically having marked lymphocytosis and splenomegaly in the absence of 
      lymphadenopathy. It is defined as a mature B-cell leukemia with more than 55% 
      circulating prolymphocytes. Leukemic mantle cell lymphoma and chronic lymphocytic 
      leukemia in prolymphocytic transformation must be excluded. METHODS: Case 
      archives were retrospectively reviewed for B-PLL in patients without a previous 
      diagnosis of chronic lymphocytic leukemia or other B-cell neoplasm. RESULTS: We 
      identified six cases of B-PLL with available cytogenetic data, five of which 
      showed evidence of aberrations in MYC. Three cases showed additional signals for 
      the MYC gene by fluorescence in situ hybridization (FISH), and two cases 
      demonstrated t(8;14)MYC/IGH by karyotyping or FISH. High levels of MYC protein 
      expression were detected in all cases tested with MYC aberrations. CONCLUSIONS: 
      These results suggest that deregulation of MYC plays an important role in the 
      pathogenesis of B-PLL and expands the spectrum of B-cell neoplasms associated 
      with aberrations of MYC.
CI  - Copyright(c) by the American Society for Clinical Pathology.
FAU - Flatley, Ellen
AU  - Flatley E
AD  - From the Department of Pathology, Oregon Health & Science University, Portland;
FAU - Chen, Andy I
AU  - Chen AI
AD  - Department of Hematology-Oncology, Knight Cancer Institute, Oregon Health & 
      Science University, Portland;
FAU - Zhao, Xiangrong
AU  - Zhao X
AD  - Hematopathology Section, Laboratory of Pathology, Center for Cancer Research, 
      National Cancer Institute, Bethesda, MD; and.
FAU - Jaffe, Elaine S
AU  - Jaffe ES
AD  - Hematopathology Section, Laboratory of Pathology, Center for Cancer Research, 
      National Cancer Institute, Bethesda, MD; and.
FAU - Dunlap, Jennifer B
AU  - Dunlap JB
AD  - From the Department of Pathology, Oregon Health & Science University, Portland;
FAU - Pittaluga, Stefania
AU  - Pittaluga S
AD  - Hematopathology Section, Laboratory of Pathology, Center for Cancer Research, 
      National Cancer Institute, Bethesda, MD; and.
FAU - Abdullah, Shahed
AU  - Abdullah S
AD  - Hematopathology Section, Laboratory of Pathology, Center for Cancer Research, 
      National Cancer Institute, Bethesda, MD; and.
FAU - Olson, Susan B
AU  - Olson SB
AD  - Knight Diagnostic Laboratory, Knight Cancer Institute, Oregon Health & Science 
      University, Portland.
FAU - Spurgeon, Stephen E
AU  - Spurgeon SE
AD  - Department of Hematology-Oncology, Knight Cancer Institute, Oregon Health & 
      Science University, Portland;
FAU - Fan, Guang
AU  - Fan G
AD  - From the Department of Pathology, Oregon Health & Science University, Portland; 
      fang@ohsu.edu.
LA  - eng
GR  - Intramural NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Intramural
PT  - Research Support, Non-U.S. Gov't
PL  - England
TA  - Am J Clin Pathol
JT  - American journal of clinical pathology
JID - 0370470
RN  - 0 (MYC protein, human)
RN  - 0 (Proto-Oncogene Proteins c-myc)
SB  - IM
MH  - Aged
MH  - Aged, 80 and over
MH  - Female
MH  - Humans
MH  - In Situ Hybridization, Fluorescence
MH  - Karyotyping
MH  - Leukemia, Prolymphocytic, B-Cell/*genetics/pathology
MH  - Leukocytosis/*genetics/pathology
MH  - Lymphocytes/pathology
MH  - Male
MH  - Middle Aged
MH  - Proto-Oncogene Proteins c-myc/*genetics
MH  - Retrospective Studies
OTO - NOTNLM
OT  - Cytogenetics
OT  - FISH
OT  - Leukemia
OT  - MYC
OT  - Prolymphocytic leukemia
EDAT- 2014/08/16 06:00
MHDA- 2014/10/18 06:00
CRDT- 2014/08/16 06:00
PHST- 2014/08/16 06:00 [entrez]
PHST- 2014/08/16 06:00 [pubmed]
PHST- 2014/10/18 06:00 [medline]
AID - 142/3/347 [pii]
AID - 10.1309/AJCPUBHM8U7ZFLOB [doi]
PST - ppublish
SO  - Am J Clin Pathol. 2014 Sep;142(3):347-54. doi: 10.1309/AJCPUBHM8U7ZFLOB.