PMID- 25126115
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20140815
LR  - 20211021
IS  - 1758-5996 (Print)
IS  - 1758-5996 (Electronic)
IS  - 1758-5996 (Linking)
VI  - 6
IP  - 1
DP  - 2014
TI  - Association between Brachial-Ankle pulse wave velocity and cardiac autonomic 
      neuropathy in type 2 diabetes.
PG  - 82
LID - 10.1186/1758-5996-6-82 [doi]
LID - 82
AB  - BACKGROUND: Cardiac autonomic neuropathy (CAN) is a common complication of type 2 
      diabetes mellitus (T2DM). Brachial-ankle pulse wave velocity (baPWV) is known to 
      be a good surrogate marker of vascular damages. The goal of this study was to 
      investigate the relationship between BaPWV and CAN in T2DM. METHODS: A total of 
      148 patients who had no apparent history of cardiovascular condition were 
      enrolled consecutively in this study. The correlation between increased baPWV and 
      CAN was analyzed. CAN was evaluated by five standard cardiovascular reflex tests 
      (CARTs) according to the Ewing's protocol: 1) heart rate variation during deep 
      breathing, 2) heart rate response to standing, 3) Valsalva maneuver, 4) postural 
      systolic blood pressure (BP) change, 5) Sustained handgrip test. CAN was defined 
      as the presence of at least two abnormal tests. RESULTS: The mean age of patients 
      was 59.8 +/- 7.8 years. The mean duration of diabetes was 6.0(2.0-11.0) years. The 
      mean baPWV was 1665.5(1482.0-1940.0) cm/sec. Subjects with CAN were older and had 
      high BMI, baPWV compared with those without CAN. The proportion of patients with 
      diabetic peripheral neuropathy was higher in subjects with CAN. After adjusting 
      for other confounding risk factors, baPWV (odds ratio = 8.496, 95% CI: 
      1.216-59.348; P = 0.031) remained as independent risk factors for CAN. The number 
      of abnormal CARTs increased gradually with increasing baPWV (correlation 
      coefficient =0.255, p = 0.002). CONCLUSION: Increased baPWV was significantly 
      correlated with CAN in patients with type 2 diabetes.
FAU - Wu, Nan
AU  - Wu N
AD  - The Institute of Endocrinology and Diabetology, Huashan Hospital, Shanghai 
      Medical College, Fudan University, 12 Middle Wulumuqi Road, Shanghai, China.
FAU - Cai, Xiaoling
AU  - Cai X
AD  - The Emergency Department, Zhongshan Hospital, Shanghai Medical College, Fudan 
      University, 180 Fenglin Road, Shanghai, China.
FAU - Ye, Kuanping
AU  - Ye K
AD  - The Institute of Endocrinology and Diabetology, Huashan Hospital, Shanghai 
      Medical College, Fudan University, 12 Middle Wulumuqi Road, Shanghai, China.
FAU - Li, Yintao
AU  - Li Y
AD  - The Institute of Endocrinology and Diabetology, Huashan Hospital, Shanghai 
      Medical College, Fudan University, 12 Middle Wulumuqi Road, Shanghai, China.
FAU - He, Min
AU  - He M
AD  - The Institute of Endocrinology and Diabetology, Huashan Hospital, Shanghai 
      Medical College, Fudan University, 12 Middle Wulumuqi Road, Shanghai, China.
FAU - Zhao, Weiwei
AU  - Zhao W
AD  - The Institute of Endocrinology and Diabetology, Huashan Hospital, Shanghai 
      Medical College, Fudan University, 12 Middle Wulumuqi Road, Shanghai, China.
FAU - Hu, Renming
AU  - Hu R
AD  - The Institute of Endocrinology and Diabetology, Huashan Hospital, Shanghai 
      Medical College, Fudan University, 12 Middle Wulumuqi Road, Shanghai, China.
LA  - eng
PT  - Journal Article
DEP - 20140730
PL  - England
TA  - Diabetol Metab Syndr
JT  - Diabetology & metabolic syndrome
JID - 101488958
PMC - PMC4132900
OTO - NOTNLM
OT  - Brachial-ankle pulse wave velocity
OT  - Cardiac autonomic neuropathy
OT  - Type 2 diabetes
EDAT- 2014/08/16 06:00
MHDA- 2014/08/16 06:01
PMCR- 2014/07/30
CRDT- 2014/08/16 06:00
PHST- 2014/04/29 00:00 [received]
PHST- 2014/07/10 00:00 [accepted]
PHST- 2014/08/16 06:00 [entrez]
PHST- 2014/08/16 06:00 [pubmed]
PHST- 2014/08/16 06:01 [medline]
PHST- 2014/07/30 00:00 [pmc-release]
AID - 346 [pii]
AID - 10.1186/1758-5996-6-82 [doi]
PST - epublish
SO  - Diabetol Metab Syndr. 2014 Jul 30;6(1):82. doi: 10.1186/1758-5996-6-82. 
      eCollection 2014.