PMID- 25127684
OWN - NLM
STAT- MEDLINE
DCOM- 20150526
LR  - 20211021
IS  - 1872-7549 (Electronic)
IS  - 0166-4328 (Print)
IS  - 0166-4328 (Linking)
VI  - 274
DP  - 2014 Nov 1
TI  - Tolerance to the locomotor-activating effects of 
      3,4-methylenedioxymethamphetamine (MDMA) predicts escalation of MDMA 
      self-administration and cue-induced reinstatement of MDMA seeking in rats.
PG  - 143-8
LID - S0166-4328(14)00522-1 [pii]
LID - 10.1016/j.bbr.2014.08.010 [doi]
AB  - Pre-clinical studies of individual differences in addiction vulnerability have 
      been increasing over recent years, but the amphetamine derivative 
      3,4-methylenedioxymethamphetamine (MDMA; ecstasy) has received relatively little 
      attention in this regard. Previously, we reported large individual differences 
      both in rats' initial behavioral response to experimenter-administered MDMA and 
      their degree of behavioral sensitization to repeated administration. To determine 
      whether these differences could predict subsequent patterns of MDMA-taking or 
      -seeking behaviors we used the self-administration-extinction-reinstatement model 
      to examine addiction-like behavior (i.e., escalation of MDMA self-administration 
      and cue-induced reinstatement of MDMA seeking) in rats a priori characterized for 
      either locomotor sensitization or tolerance to MDMA. Rats that developed 
      tolerance to the locomotor-activating effects of MDMA had a significantly larger 
      locomotor response to the first MDMA injection relative to rats that developed 
      sensitization. Importantly, rats that developed tolerance subsequently displayed 
      an escalation of MDMA self-administration over days, as well as clear cue-induced 
      reinstatement of MDMA seeking following extinction. Conversely, rats that 
      developed locomotor sensitization to MDMA subsequently maintained relatively 
      stable levels of MDMA self-administration over days and showed no cue-induced 
      reinstatement of MDMA seeking. These results show that differences in the level 
      of psychomotor activation following acute and repeated MDMA administration can 
      reliably predict two important addiction-like behaviors in rats, which may have 
      implications in the prediction of compulsive MDMA use in humans.
CI  - Copyright (c) 2014 Elsevier B.V. All rights reserved.
FAU - Ball, Kevin T
AU  - Ball KT
AD  - Department of Psychology, Bloomsburg University of Pennsylvania, 400 E. 2nd St., 
      Bloomsburg, PA 17815, USA. Electronic address: kball@bloomu.edu.
FAU - Slane, Mylissa
AU  - Slane M
AD  - Department of Psychology, Bloomsburg University of Pennsylvania, 400 E. 2nd St., 
      Bloomsburg, PA 17815, USA.
LA  - eng
GR  - R03 DA027960/DA/NIDA NIH HHS/United States
GR  - R15 DA035432/DA/NIDA NIH HHS/United States
GR  - DA027960/DA/NIDA NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
DEP - 20140812
PL  - Netherlands
TA  - Behav Brain Res
JT  - Behavioural brain research
JID - 8004872
RN  - 0 (Hallucinogens)
RN  - KE1SEN21RM (N-Methyl-3,4-methylenedioxyamphetamine)
SB  - IM
MH  - Analysis of Variance
MH  - Animals
MH  - Animals, Newborn
MH  - Conditioning, Operant/drug effects
MH  - *Cues
MH  - Drug-Seeking Behavior/*drug effects
MH  - Exploratory Behavior/drug effects
MH  - Extinction, Psychological/drug effects
MH  - Female
MH  - Grooming/drug effects
MH  - Hallucinogens/*administration & dosage
MH  - Male
MH  - Motor Activity/*drug effects
MH  - N-Methyl-3,4-methylenedioxyamphetamine/*administration & dosage
MH  - Rats
MH  - Rats, Wistar
MH  - *Reinforcement, Psychology
MH  - Self Administration
PMC - PMC4179501
MID - NIHMS623054
OTO - NOTNLM
OT  - Cue
OT  - MDMA
OT  - Reinstatement
OT  - Self-administration
OT  - Sensitization
OT  - Tolerance
COIS- Conflicts of Interest: None declared.
EDAT- 2014/08/17 06:00
MHDA- 2015/05/27 06:00
PMCR- 2015/11/01
CRDT- 2014/08/17 06:00
PHST- 2014/03/08 00:00 [received]
PHST- 2014/07/04 00:00 [revised]
PHST- 2014/08/04 00:00 [accepted]
PHST- 2014/08/17 06:00 [entrez]
PHST- 2014/08/17 06:00 [pubmed]
PHST- 2015/05/27 06:00 [medline]
PHST- 2015/11/01 00:00 [pmc-release]
AID - S0166-4328(14)00522-1 [pii]
AID - 10.1016/j.bbr.2014.08.010 [doi]
PST - ppublish
SO  - Behav Brain Res. 2014 Nov 1;274:143-8. doi: 10.1016/j.bbr.2014.08.010. Epub 2014 
      Aug 12.