PMID- 25128203
OWN - NLM
STAT- MEDLINE
DCOM- 20150512
LR  - 20220409
IS  - 1574-4647 (Electronic)
IS  - 0161-9152 (Print)
IS  - 0161-9152 (Linking)
VI  - 36
IP  - 5
DP  - 2014
TI  - Strength training reduces circulating interleukin-6 but not brain-derived 
      neurotrophic factor in community-dwelling elderly individuals.
PG  - 9704
LID - 10.1007/s11357-014-9704-6 [doi]
LID - 9704
AB  - Ageing is associated with a chronic low-grade inflammatory profile (CLIP). 
      Physical exercise could circumvent the deleterious effects of CLIP by influencing 
      circulating inflammatory mediators and neurotrophic growth factors. This study 
      aimed at assessing whether 12 weeks of progressive strength training (PST) 
      influences circulating brain-derived neurotrophic factor (BDNF), interleukin 
      (IL)-6 and IL-10 in elderly individuals. Forty community-dwelling persons aged 
      62-72 years participated. Twenty participants were assigned to 12-week PST 
      (70-80 % of maximal strength, three times per week). Matched control individuals 
      (n = 20) maintained daily activity levels. Serum was collected for BDNF, IL-6 and 
      IL-10 assay from all participants before and after 12 weeks (for PST subjects 
      24-48 h after the last training). In PST, muscle strength was significantly 
      improved (+49 % for leg extension, p = 0.039), and basal IL-6 levels 
      significantly reduced (p = 0.001), which remained unchanged in control 
      (p = 0.117). No significant change in BDNF was observed in PST subjects 
      (p = 0.147) or control (p = 0.563). IL-10 was below the detection limit in most 
      subjects. Gender and health status did not influence the results. Our results 
      show that after 12-week PST, muscle performance improved significantly, and basal 
      levels of IL-6 were significantly decreased in older subjects. However, serum 
      BDNF was not altered. The lack of an observable change in BDNF might be due to a 
      short-lived BDNF response, occurring acutely following exercise, which might have 
      been washed out when sampling. Furthermore, blood levels of BDNF may not reflect 
      parallel increases that occur locally in the brain and muscle. These hypotheses 
      need confirmation by further studies.
FAU - Forti, Louis Nuvagah
AU  - Forti LN
AD  - Gerontology Department and Frailty in Aging Research (FRIA) Group, Faculty of 
      Medicine and Pharmacy, Vrije Universiteit Brussel, Laarbeeklaan 103, B-1090, 
      Brussels, Belgium.
FAU - Njemini, Rose
AU  - Njemini R
FAU - Beyer, Ingo
AU  - Beyer I
FAU - Eelbode, Elke
AU  - Eelbode E
FAU - Meeusen, Romain
AU  - Meeusen R
FAU - Mets, Tony
AU  - Mets T
FAU - Bautmans, Ivan
AU  - Bautmans I
LA  - eng
PT  - Controlled Clinical Trial
PT  - Journal Article
DEP - 20140816
PL  - Netherlands
TA  - Age (Dordr)
JT  - Age (Dordrecht, Netherlands)
JID - 101250497
RN  - 0 (Biomarkers)
RN  - 0 (Brain-Derived Neurotrophic Factor)
RN  - 0 (Interleukin-6)
SB  - IM
MH  - Adult
MH  - Aged
MH  - Aged, 80 and over
MH  - Aging/*physiology
MH  - Biomarkers/blood
MH  - Brain-Derived Neurotrophic Factor/*blood
MH  - Enzyme-Linked Immunosorbent Assay
MH  - Exercise/*physiology
MH  - Female
MH  - Follow-Up Studies
MH  - Healthy Volunteers
MH  - Humans
MH  - Interleukin-6/*blood
MH  - Male
MH  - Middle Aged
MH  - Prospective Studies
MH  - Resistance Training/*methods
PMC - PMC4453935
EDAT- 2014/08/17 06:00
MHDA- 2015/05/13 06:00
PMCR- 2015/10/01
CRDT- 2014/08/17 06:00
PHST- 2014/04/22 00:00 [received]
PHST- 2014/08/04 00:00 [accepted]
PHST- 2014/08/17 06:00 [entrez]
PHST- 2014/08/17 06:00 [pubmed]
PHST- 2015/05/13 06:00 [medline]
PHST- 2015/10/01 00:00 [pmc-release]
AID - 9704 [pii]
AID - 10.1007/s11357-014-9704-6 [doi]
PST - ppublish
SO  - Age (Dordr). 2014;36(5):9704. doi: 10.1007/s11357-014-9704-6. Epub 2014 Aug 16.