PMID- 25128393
OWN - NLM
STAT- MEDLINE
DCOM- 20151103
LR  - 20211021
IS  - 1873-2380 (Electronic)
IS  - 0021-9290 (Print)
IS  - 0021-9290 (Linking)
VI  - 47
IP  - 12
DP  - 2014 Sep 22
TI  - Pulmonary artery relative area change is inversely related to ex vivo measured 
      arterial elastic modulus in the canine model of acute pulmonary embolization.
PG  - 2904-10
LID - S0021-9290(14)00394-7 [pii]
LID - 10.1016/j.jbiomech.2014.07.013 [doi]
AB  - A low relative area change (RAC) of the proximal pulmonary artery (PA) over the 
      cardiac cycle is a good predictor of mortality from right ventricular failure in 
      patients with pulmonary hypertension (PH). The relationship between RAC and local 
      mechanical properties of arteries, which are known to stiffen in acute and 
      chronic PH, is not clear, however. In this study, we estimated elastic moduli of 
      three PAs (MPA, LPA and RPA: main, left and right PAs) at the physiological state 
      using mechanical testing data and correlated these estimated elastic moduli to 
      RAC measured in vivo with both phase-contrast magnetic resonance imaging (PC-MRI) 
      and M-mode echocardiography (on RPA only). We did so using data from a canine 
      model of acute PH due to embolization to assess the sensitivity of RAC to changes 
      in elastic modulus in the absence of chronic PH-induced arterial remodeling. We 
      found that elastic modulus increased with embolization-induced PH, presumably a 
      consequence of increased collagen engagement, which corresponds well to decreased 
      RAC. Furthermore, RAC was inversely related to elastic modulus. Finally, we found 
      MRI and echocardiography yielded comparable estimates of RAC. We conclude that 
      RAC of proximal PAs can be obtained from either MRI or echocardiography and a 
      change in RAC indicates a change in elastic modulus of proximal PAs detectable 
      even in the absence of chronic PH-induced arterial remodeling. The correlation 
      between RAC and elastic modulus of proximal PAs may be useful for prognoses and 
      to monitor the effects of therapeutic interventions in patients with PH.
CI  - Copyright (c) 2014 Elsevier Ltd. All rights reserved.
FAU - Tian, Lian
AU  - Tian L
AD  - Department of Biomedical Engineering, University of Wisconsin-Madison, 1550 
      Engineering Drive, Madison, WI 53706-1609, USA.
FAU - Kellihan, Heidi B
AU  - Kellihan HB
AD  - School of Veterinary Medicine, University of Wisconsin-Madison, 2015 Linden 
      Drive, Madison, WI 53706-1102, USA.
FAU - Henningsen, Joseph
AU  - Henningsen J
AD  - Department of Biomedical Engineering, University of Wisconsin-Madison, 1550 
      Engineering Drive, Madison, WI 53706-1609, USA.
FAU - Bellofiore, Alessandro
AU  - Bellofiore A
AD  - Department of Biomedical Engineering, University of Wisconsin-Madison, 1550 
      Engineering Drive, Madison, WI 53706-1609, USA.
FAU - Forouzan, Omid
AU  - Forouzan O
AD  - Department of Biomedical Engineering, University of Wisconsin-Madison, 1550 
      Engineering Drive, Madison, WI 53706-1609, USA.
FAU - Roldan-Alzate, Alejandro
AU  - Roldan-Alzate A
AD  - Department of Radiology, University of Wisconsin-Madison, 600 Highland Avenue, 
      Madison, WI 53792-3252, USA.
FAU - Consigny, Daniel W
AU  - Consigny DW
AD  - Department of Radiology, University of Wisconsin-Madison, 600 Highland Avenue, 
      Madison, WI 53792-3252, USA.
FAU - Gunderson, McLean
AU  - Gunderson M
AD  - Department of Surgery, Division of Otolaryngology-Head and Neck Surgery, 
      University of Wisconsin-Madison, 600 Highland Avenue, Madison, WI 53792-3252, 
      USA.
FAU - Dailey, Seth H
AU  - Dailey SH
AD  - Department of Surgery, Division of Otolaryngology-Head and Neck Surgery, 
      University of Wisconsin-Madison, 600 Highland Avenue, Madison, WI 53792-3252, 
      USA.
FAU - Francois, Christopher J
AU  - Francois CJ
AD  - Department of Radiology, University of Wisconsin-Madison, 600 Highland Avenue, 
      Madison, WI 53792-3252, USA.
FAU - Chesler, Naomi C
AU  - Chesler NC
AD  - Department of Biomedical Engineering, University of Wisconsin-Madison, 1550 
      Engineering Drive, Madison, WI 53706-1609, USA. Electronic address: 
      chesler@engr.wisc.edu.
LA  - eng
GR  - R01 HL105598/HL/NHLBI NIH HHS/United States
GR  - R01-HL105598/HL/NHLBI NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PT  - Research Support, Non-U.S. Gov't
DEP - 20140730
PL  - United States
TA  - J Biomech
JT  - Journal of biomechanics
JID - 0157375
SB  - IM
MH  - Animals
MH  - Disease Models, Animal
MH  - Dogs
MH  - Elastic Modulus
MH  - Female
MH  - Hypertension, Pulmonary/*physiopathology
MH  - Magnetic Resonance Imaging
MH  - Male
MH  - Pulmonary Artery/*physiopathology
PMC - PMC4427361
MID - NIHMS622993
OTO - NOTNLM
OT  - Elastic modulus
OT  - Embolization
OT  - Pulmonary hypertension
OT  - Relative area change
COIS- Conflict of Interest No conflicts of interest, financial or otherwise, are 
      declared by the author(s).
EDAT- 2014/08/17 06:00
MHDA- 2015/11/04 06:00
PMCR- 2015/09/22
CRDT- 2014/08/17 06:00
PHST- 2014/02/06 00:00 [received]
PHST- 2014/07/16 00:00 [revised]
PHST- 2014/07/22 00:00 [accepted]
PHST- 2014/08/17 06:00 [entrez]
PHST- 2014/08/17 06:00 [pubmed]
PHST- 2015/11/04 06:00 [medline]
PHST- 2015/09/22 00:00 [pmc-release]
AID - S0021-9290(14)00394-7 [pii]
AID - 10.1016/j.jbiomech.2014.07.013 [doi]
PST - ppublish
SO  - J Biomech. 2014 Sep 22;47(12):2904-10. doi: 10.1016/j.jbiomech.2014.07.013. Epub 
      2014 Jul 30.