PMID- 25128453
OWN - NLM
STAT- MEDLINE
DCOM- 20150713
LR  - 20180816
IS  - 1573-2509 (Electronic)
IS  - 0920-9964 (Linking)
VI  - 159
IP  - 1
DP  - 2014 Oct
TI  - Serum levels of BDNF, folate and homocysteine: in relation to hippocampal volume 
      and psychopathology in drug naive, first episode schizophrenia.
PG  - 51-5
LID - S0920-9964(14)00390-9 [pii]
LID - 10.1016/j.schres.2014.07.033 [doi]
AB  - OBJECTIVE: The present study was to examine serum levels of brain-derived 
      neurotrophic factor (BDNF), folate, homocysteine (Hcy), and their relationships 
      with hippocampal volume and psychopathology in drug naive, first episode 
      schizophrenia. METHOD: Drug naive, first episode schizophrenia patients and 
      healthy controls were enrolled in the study. Serum levels of BDNF, folate and Hcy 
      were measured using enzyme-linked immunosorbent assay (ELISA), 
      electrochemiluminescence immunoassay (ECLIA), and enzymatic cycling method 
      respectively. Hippocampus was parcellated and bilateral hippocampal volumes were 
      measured using FreeSurfer. RESULTS: Forty-six patients with drug naive, first 
      episode schizophrenia (SZ group) and 30 healthy controls (control group) were 
      enrolled. The SZ group had significantly lower serum levels of BDNF and folate, 
      and significantly higher serum levels of Hcy compared with the control group 
      (p=0.013, p<0.001, p=0.003 respectively). There were no significant differences 
      in hippocampal volumes between the two groups (ps>0.2). Within the SZ group, 
      there were significant positive relationships between serum levels of BDNF and 
      both left and right hippocampal volumes (r=0.327, p=0.026; r=0.338, p=0.022 
      respectively). In contrast, such relationships did not exist in the control 
      group. Within the SZ group, there were significant negative relationships between 
      serum levels of folate and PANSS-total scores and PANSS-negative symptom scores 
      (r=0.319, p=0.031; r=0.321, p=0.030 respectively); and there was a positive 
      relationship between serum levels of Hcy and PANSS-total scores (r=0.312, 
      p=0.035). Controlling for potential confounding variables resulted in similar 
      findings. CONCLUSIONS: Drug naive, first episode schizophrenia presents decreased 
      serum levels of BDNF, folate and increased serum levels of Hcy, which may play an 
      important role in the neurodevelopmental process and clinical manifestation of 
      schizophrenia.
CI  - Copyright (c) 2014. Published by Elsevier B.V.
FAU - Song, Xueqin
AU  - Song X
AD  - The First Affiliated Hospital/Zhengzhou University, Zhengzhou, China; Henan 
      Province Biological Psychiatry Key Laboratory, Xinxiang Medical University, 
      Xinxiang, China; Department of Psychiatry, University of Massachusetts Medical 
      School, Worcester, MA, USA. Electronic address: sxqzhll@126.com.
FAU - Fan, Xiaoduo
AU  - Fan X
AD  - Department of Psychiatry, University of Massachusetts Medical School, Worcester, 
      MA, USA.
FAU - Li, Xue
AU  - Li X
AD  - The First Affiliated Hospital/Zhengzhou University, Zhengzhou, China.
FAU - Kennedy, David
AU  - Kennedy D
AD  - Department of Psychiatry, University of Massachusetts Medical School, Worcester, 
      MA, USA.
FAU - Pang, Lijuan
AU  - Pang L
AD  - The First Affiliated Hospital/Zhengzhou University, Zhengzhou, China.
FAU - Quan, Meina
AU  - Quan M
AD  - Department of Psychiatry, University of Massachusetts Medical School, Worcester, 
      MA, USA.
FAU - Chen, Xumei
AU  - Chen X
AD  - The First Affiliated Hospital/Zhengzhou University, Zhengzhou, China.
FAU - Gao, Jinsong
AU  - Gao J
AD  - The First Affiliated Hospital/Zhengzhou University, Zhengzhou, China.
FAU - Zhang, Wei
AU  - Zhang W
AD  - The First Affiliated Hospital/Zhengzhou University, Zhengzhou, China.
FAU - Zhang, Jianjiang
AU  - Zhang J
AD  - The First Affiliated Hospital/Zhengzhou University, Zhengzhou, China.
FAU - Lv, Luxian
AU  - Lv L
AD  - Henan Province Biological Psychiatry Key Laboratory, Xinxiang Medical University, 
      Xinxiang, China; Henan Province Mental Hospital, The Second Affiliated 
      Hospital/Xinxiang Medical University, Xinxiang, China. Electronic address: 
      lvluxian@126.com.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20140812
PL  - Netherlands
TA  - Schizophr Res
JT  - Schizophrenia research
JID - 8804207
RN  - 0 (Brain-Derived Neurotrophic Factor)
RN  - 0LVT1QZ0BA (Homocysteine)
RN  - 7171WSG8A2 (BDNF protein, human)
RN  - 935E97BOY8 (Folic Acid)
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - Blood Chemical Analysis
MH  - Brain-Derived Neurotrophic Factor/*blood
MH  - Enzyme-Linked Immunosorbent Assay
MH  - Female
MH  - Folic Acid/*blood
MH  - Hippocampus/*pathology
MH  - Homocysteine/*blood
MH  - Humans
MH  - Image Processing, Computer-Assisted
MH  - Immunoassay
MH  - Male
MH  - Organ Size
MH  - Psychiatric Status Rating Scales
MH  - Schizophrenia/*blood/*pathology
MH  - Schizophrenic Psychology
MH  - Young Adult
OTO - NOTNLM
OT  - BDNF
OT  - Folate
OT  - Hippocampus
OT  - Homocysteine
OT  - Schizophrenia
EDAT- 2014/08/17 06:00
MHDA- 2015/07/15 06:00
CRDT- 2014/08/17 06:00
PHST- 2014/03/06 00:00 [received]
PHST- 2014/07/15 00:00 [revised]
PHST- 2014/07/25 00:00 [accepted]
PHST- 2014/08/17 06:00 [entrez]
PHST- 2014/08/17 06:00 [pubmed]
PHST- 2015/07/15 06:00 [medline]
AID - S0920-9964(14)00390-9 [pii]
AID - 10.1016/j.schres.2014.07.033 [doi]
PST - ppublish
SO  - Schizophr Res. 2014 Oct;159(1):51-5. doi: 10.1016/j.schres.2014.07.033. Epub 2014 
      Aug 12.