PMID- 25128825
OWN - NLM
STAT- MEDLINE
DCOM- 20141111
LR  - 20210816
IS  - 1090-2104 (Electronic)
IS  - 0006-291X (Linking)
VI  - 451
IP  - 4
DP  - 2014 Sep 5
TI  - Modulation of cytokine expression in human macrophages by endocrine-disrupting 
      chemical Bisphenol-A.
PG  - 592-8
LID - S0006-291X(14)01446-6 [pii]
LID - 10.1016/j.bbrc.2014.08.031 [doi]
AB  - Exposure to environmental endocrine-disrupting chemical Bisphenol-A (BPA) is 
      often associated with dysregulated immune homeostasis, but the mechanisms remain 
      unclear. In the present study, the effects of BPA on the cytokines responses of 
      human macrophages were investigated. Treatment with BPA increased 
      pro-inflammation cytokines tumor necrosis factor-alpha (TNF-alpha) and interleukin-6 
      (IL-6) production, but decreased anti-inflammation cytokines interleukin-10 
      (IL-10) and transforming growth factor-beta (TGF-beta) production in THP1 macrophages, 
      as well as in primary human macrophages. BPA effected cytokines expression 
      through estrogen receptor alpha/beta (ERalpha/beta)-dependent mechanism with the evidence of 
      ERalpha/beta antagonist reversed the expression of cytokines. We also identified that 
      activation of extracellular regulated protein kinases (ERK)/nuclear factor kappaB 
      (NF-kappaB) signal cascade marked the effects of BPA on cytokines expression. Our 
      results indicated that BPA effected inflammatory responses of macrophages via 
      modulating of cytokines expression, and provided a new insight into the link 
      between exposure to BPA and human health.
CI  - Copyright (c) 2014 Elsevier Inc. All rights reserved.
FAU - Liu, Yanzhen
AU  - Liu Y
AD  - State Key Laboratory of Applied Microbiology Southern China, Guangzhou 510070, PR 
      China; Guangdong Provincial Key Laboratory of Microbial Culture Collection and 
      Application, Guangdong Institute of Microbiology, Guangzhou 510070, PR China.
FAU - Mei, Chenfang
AU  - Mei C
AD  - State Key Laboratory of Applied Microbiology Southern China, Guangzhou 510070, PR 
      China; Guangdong Provincial Key Laboratory of Microbial Culture Collection and 
      Application, Guangdong Institute of Microbiology, Guangzhou 510070, PR China.
FAU - Liu, Hao
AU  - Liu H
AD  - Affiliated Cancer Hospital and Cancer Research Institute, Guangzhou Medical 
      University, Guangzhou 510095, PR China.
FAU - Wang, Hongsheng
AU  - Wang H
AD  - Department of Microbial and Biochemical Pharmacy, School of Pharmaceutical 
      Sciences, Sun Yat-sen University, Guangzhou 510006, PR China.
FAU - Zeng, Guoqu
AU  - Zeng G
AD  - State Key Laboratory of Applied Microbiology Southern China, Guangzhou 510070, PR 
      China; Guangdong Provincial Key Laboratory of Microbial Culture Collection and 
      Application, Guangdong Institute of Microbiology, Guangzhou 510070, PR China.
FAU - Lin, Jianhui
AU  - Lin J
AD  - State Key Laboratory of Applied Microbiology Southern China, Guangzhou 510070, PR 
      China; Guangdong Provincial Key Laboratory of Microbial Culture Collection and 
      Application, Guangdong Institute of Microbiology, Guangzhou 510070, PR China.
FAU - Xu, Meiying
AU  - Xu M
AD  - State Key Laboratory of Applied Microbiology Southern China, Guangzhou 510070, PR 
      China; Guangdong Provincial Key Laboratory of Microbial Culture Collection and 
      Application, Guangdong Institute of Microbiology, Guangzhou 510070, PR China. 
      Electronic address: xumy@gdim.cn.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20140813
PL  - United States
TA  - Biochem Biophys Res Commun
JT  - Biochemical and biophysical research communications
JID - 0372516
RN  - 0 (Benzhydryl Compounds)
RN  - 0 (Cytokines)
RN  - 0 (ESR1 protein, human)
RN  - 0 (Estrogen Receptor alpha)
RN  - 0 (Interleukin-6)
RN  - 0 (NF-kappa B)
RN  - 0 (Phenols)
RN  - 0 (Tumor Necrosis Factor-alpha)
RN  - 130068-27-8 (Interleukin-10)
RN  - MLT3645I99 (bisphenol A)
SB  - IM
MH  - Benzhydryl Compounds/*toxicity
MH  - Cell Line, Tumor
MH  - Cytokines/*biosynthesis
MH  - Estrogen Receptor alpha/drug effects/physiology
MH  - Humans
MH  - Interleukin-10/antagonists & inhibitors
MH  - Interleukin-6/biosynthesis
MH  - Macrophages/*drug effects/metabolism
MH  - NF-kappa B/biosynthesis/physiology
MH  - Phenols/*toxicity
MH  - Signal Transduction/drug effects
MH  - Tumor Necrosis Factor-alpha/biosynthesis
OTO - NOTNLM
OT  - Bisphenol-A
OT  - Cytokine
OT  - Inflammation
OT  - Macrophage
EDAT- 2014/08/17 06:00
MHDA- 2014/11/12 06:00
CRDT- 2014/08/17 06:00
PHST- 2014/08/04 00:00 [received]
PHST- 2014/08/06 00:00 [accepted]
PHST- 2014/08/17 06:00 [entrez]
PHST- 2014/08/17 06:00 [pubmed]
PHST- 2014/11/12 06:00 [medline]
AID - S0006-291X(14)01446-6 [pii]
AID - 10.1016/j.bbrc.2014.08.031 [doi]
PST - ppublish
SO  - Biochem Biophys Res Commun. 2014 Sep 5;451(4):592-8. doi: 
      10.1016/j.bbrc.2014.08.031. Epub 2014 Aug 13.