PMID- 25128962
OWN - NLM
STAT- MEDLINE
DCOM- 20150330
LR  - 20211021
IS  - 1435-702X (Electronic)
IS  - 0721-832X (Linking)
VI  - 252
IP  - 10
DP  - 2014 Oct
TI  - Measurement of retinal nerve fiber layer and macular ganglion cell-inner 
      plexiform layer with spectral-domain optical coherence tomography in patients 
      with optic nerve head drusen.
PG  - 1653-60
LID - 10.1007/s00417-014-2773-5 [doi]
AB  - PURPOSE: To evaluate the effect of optic nerve head drusen (ONHD) on the retinal 
      nerve fiber layer (RNFL) and macular ganglion cell-inner plexiform layer (GCIPL) 
      using Cirrus optical coherence tomography (OCT). METHODS: Fifty-seven eyes of 
      thirty patients with ONHD and thirty-eight eyes of twenty age-matched and 
      sex-matched control subjects underwent circumpapillary and macular scanning using 
      Cirrus OCT. The percentages of eyes with abnormal GCIPL and RNFL values according 
      to the Cirrus normative data were analysed and compared. RESULTS: Overall, eyes 
      with ONHD showed abnormally reduced values for average and minimum GCIPL 
      thicknesses in 35 % and 45 % of cases compared to 2 % for both values in control 
      eyes (P < 0.001). Average RNFL thickness comparison between eyes with ONHD and 
      normal eyes revealed abnormal thinning in 33 % vs. 0 %, respectively (p = 0.002). 
      The percentage of abnormal thinning increased with higher grades of ONHD for all 
      the parameters evaluated, so that in grade III drusen, values were abnormally 
      reduced in 80 % of eyes in all three analyses. Regarding buried ONHD, 30 % and 4 
      % of eyes had an abnormally reduced minimum GCIPL and average RNFL thickness, 
      respectively. Furthermore, 26 % of these eyes had abnormal GCIPL exams with a 
      normal or increased RNFL thickness. CONCLUSIONS: Both RNFL and GCIPL analysis 
      reveal significant thinning in eyes with ONHD directly correlated with drusen 
      severity. In buried ONHD, the abnormality rate was significantly higher with 
      GCIPL compared to RNFL evaluation, suggesting that GCIPL analysis might be an 
      early structural indicator of neuronal loss in the setting of thickened RNFL.
FAU - Casado, Alfonso
AU  - Casado A
AD  - Department of Ophthalmology, Hospital Universitario Ramon y Cajal. IRYCIS, 
      Carretera de Colmenar Km 9,100, 28034, Madrid, Spain, casadorojo@hotmail.es.
FAU - Rebolleda, Gema
AU  - Rebolleda G
FAU - Guerrero, Laura
AU  - Guerrero L
FAU - Leal, Marina
AU  - Leal M
FAU - Contreras, Ines
AU  - Contreras I
FAU - Oblanca, Noelia
AU  - Oblanca N
FAU - Munoz-Negrete, Francisco J
AU  - Munoz-Negrete FJ
LA  - eng
PT  - Journal Article
DEP - 20140817
PL  - Germany
TA  - Graefes Arch Clin Exp Ophthalmol
JT  - Graefe's archive for clinical and experimental ophthalmology = Albrecht von 
      Graefes Archiv fur klinische und experimentelle Ophthalmologie
JID - 8205248
SB  - IM
MH  - Adult
MH  - Amacrine Cells/*pathology
MH  - Female
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Nerve Fibers/*pathology
MH  - Neurons/*pathology
MH  - Optic Disk Drusen/classification/*diagnosis
MH  - Prospective Studies
MH  - Retinal Bipolar Cells/*pathology
MH  - Retinal Ganglion Cells/*pathology
MH  - Tomography, Optical Coherence
MH  - Visual Acuity/physiology
MH  - Young Adult
EDAT- 2014/08/19 06:00
MHDA- 2015/03/31 06:00
CRDT- 2014/08/18 06:00
PHST- 2013/11/20 00:00 [received]
PHST- 2014/08/06 00:00 [accepted]
PHST- 2014/07/11 00:00 [revised]
PHST- 2014/08/18 06:00 [entrez]
PHST- 2014/08/19 06:00 [pubmed]
PHST- 2015/03/31 06:00 [medline]
AID - 10.1007/s00417-014-2773-5 [doi]
PST - ppublish
SO  - Graefes Arch Clin Exp Ophthalmol. 2014 Oct;252(10):1653-60. doi: 
      10.1007/s00417-014-2773-5. Epub 2014 Aug 17.