PMID- 25129433
OWN - NLM
STAT- MEDLINE
DCOM- 20150217
LR  - 20180501
IS  - 1096-0341 (Electronic)
IS  - 0042-6822 (Linking)
VI  - 468-470
DP  - 2014 Nov
TI  - Porcine reproductive and respiratory syndrome virus infection triggers HMGB1 
      release to promote inflammatory cytokine production.
PG  - 1-9
LID - S0042-6822(14)00363-8 [pii]
LID - 10.1016/j.virol.2014.07.046 [doi]
AB  - The high mobility group box 1 (HMGB1) protein is an endogenous damage-associated 
      molecular pattern (DAMP) molecule involved in the pathogenesis of various 
      infectious agents. Based on meta-analysis of all publicly available microarray 
      datasets, HMGB1 has recently been proposed as the most significant immune 
      modulator during the porcine response to porcine reproductive and respiratory 
      syndrome virus (PRRSV) infection. However, the function of HMGB1 in PRRSV 
      pathogenesis is unclear. In this study, we found that PRRSV infection triggers 
      the translocation of HMGB1 from the nucleus to the extracellular milieu in 
      MARC-145 cells and porcine alveolar macrophages. Although HMGB1 has no effect on 
      PRRSV replication, HMGB1 promotes PRRSV-induced NF-kappaB activation and subsequent 
      expression of inflammatory cytokines through receptors RAGE, TLR2 and TLR4. Our 
      findings show that HMGB1 release, triggered by PRRSV infection, enhances the 
      efficiency of virus-induced inflammatory responses, thereby providing new 
      insights into the pathogenesis of PRRSV infection.
CI  - Copyright (c) 2014 Elsevier Inc. All rights reserved.
FAU - Duan, Erzhen
AU  - Duan E
AD  - State Key Laboratory of Agricultural Microbiology, College of Veterinary 
      Medicine, Huazhong Agricultural University, Wuhan 430070, China.
FAU - Wang, Dang
AU  - Wang D
AD  - State Key Laboratory of Agricultural Microbiology, College of Veterinary 
      Medicine, Huazhong Agricultural University, Wuhan 430070, China.
FAU - Luo, Rui
AU  - Luo R
AD  - State Key Laboratory of Agricultural Microbiology, College of Veterinary 
      Medicine, Huazhong Agricultural University, Wuhan 430070, China.
FAU - Luo, Jingyi
AU  - Luo J
AD  - State Key Laboratory of Agricultural Microbiology, College of Veterinary 
      Medicine, Huazhong Agricultural University, Wuhan 430070, China.
FAU - Gao, Li
AU  - Gao L
AD  - State Key Laboratory of Agricultural Microbiology, College of Veterinary 
      Medicine, Huazhong Agricultural University, Wuhan 430070, China.
FAU - Chen, Huanchun
AU  - Chen H
AD  - State Key Laboratory of Agricultural Microbiology, College of Veterinary 
      Medicine, Huazhong Agricultural University, Wuhan 430070, China.
FAU - Fang, Liurong
AU  - Fang L
AD  - State Key Laboratory of Agricultural Microbiology, College of Veterinary 
      Medicine, Huazhong Agricultural University, Wuhan 430070, China. Electronic 
      address: fanglr@mail.hzau.edu.cn.
FAU - Xiao, Shaobo
AU  - Xiao S
AD  - State Key Laboratory of Agricultural Microbiology, College of Veterinary 
      Medicine, Huazhong Agricultural University, Wuhan 430070, China. Electronic 
      address: vet@mail.hzau.edu.cn.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20140816
PL  - United States
TA  - Virology
JT  - Virology
JID - 0110674
RN  - 0 (Cytokines)
RN  - 0 (HMGB1 Protein)
SB  - IM
MH  - Animals
MH  - Cell Line
MH  - Cytokines/genetics/*metabolism
MH  - Dose-Response Relationship, Drug
MH  - Gene Expression Regulation, Viral/*immunology
MH  - HMGB1 Protein/administration & dosage/genetics/*metabolism/pharmacology
MH  - Haplorhini
MH  - Inflammation/*metabolism
MH  - Macrophages, Alveolar/metabolism/virology
MH  - Porcine respiratory and reproductive syndrome virus/*physiology
MH  - Swine
MH  - Virus Replication
OTO - NOTNLM
OT  - Cytokines
OT  - HMGB1
OT  - Inflammatory response
OT  - Porcine reproductive and respiratory syndrome virus (PRRSV)
EDAT- 2014/08/19 06:00
MHDA- 2015/02/18 06:00
CRDT- 2014/08/18 06:00
PHST- 2014/05/06 00:00 [received]
PHST- 2014/05/30 00:00 [revised]
PHST- 2014/07/23 00:00 [accepted]
PHST- 2014/08/18 06:00 [entrez]
PHST- 2014/08/19 06:00 [pubmed]
PHST- 2015/02/18 06:00 [medline]
AID - S0042-6822(14)00363-8 [pii]
AID - 10.1016/j.virol.2014.07.046 [doi]
PST - ppublish
SO  - Virology. 2014 Nov;468-470:1-9. doi: 10.1016/j.virol.2014.07.046. Epub 2014 Aug 
      16.