PMID- 25130429
OWN - NLM
STAT- MEDLINE
DCOM- 20150714
LR  - 20220309
IS  - 1099-0461 (Electronic)
IS  - 1095-6670 (Print)
IS  - 1095-6670 (Linking)
VI  - 28
IP  - 12
DP  - 2014 Dec
TI  - Natural antioxidants exhibit chemopreventive characteristics through the 
      regulation of CNC b-Zip transcription factors in estrogen-induced breast 
      carcinogenesis.
PG  - 529-38
LID - 10.1002/jbt.21594 [doi]
AB  - The objective of the present study was to characterize the role of resveratrol 
      (Res) and vitamin C (VC) in prevention of estrogen-induced breast cancer through 
      regulation of cap "n"collar (CNC) b-zip transcription factors. Human breast 
      epithelial cell line MCF-10A was treated with 17beta-estradiol (E2) and VC or Res 
      with or without E2. mRNA and protein expression levels of CNC b-zip transcription 
      factors nuclear factor erythroid 2-related factor 1 (Nrf1), nuclear factor 
      erythroid 2 related factor 2 (Nrf2), nuclear factor erythroid 2 related factor 3 
      (Nrf3), and Nrf2-regulated antioxidant enzymes superoxide dismutase 3 (SOD3) and 
      NAD(P)H: quinone oxidoreductase 1 (NQO1) were quantified. The treatment with E2 
      suppressed, whereas VC and Res prevented E2-mediated decrease in the expression 
      levels of SOD3, NQO1, Nrf2 mRNA, and protein in MCF-10A cells. The treatment with 
      E2, Res, or VC significantly increased mRNA and protein expression levels of 
      Nrf1. 17beta-Estradiol treatment significantly increased but VC or Res decreased 
      Nrf3 mRNA and protein expression levels. Our studies demonstrate that 
      estrogen-induced breast cancer might be prevented through upregulation of 
      antioxidant enzymes via Nrf-dependent pathways.
CI  - (c) 2014 Wiley Periodicals, Inc.
FAU - Chatterjee, Anwesha
AU  - Chatterjee A
AD  - Division of Pharmacology and Toxicology, School of Pharmacy, University of 
      Missouri-Kansas City, Kansas City, MO, 64108, USA. bhath@umkc.edu.
FAU - Ronghe, Amruta
AU  - Ronghe A
FAU - Singh, Bhupendra
AU  - Singh B
FAU - Bhat, Nimee K
AU  - Bhat NK
FAU - Chen, Jie
AU  - Chen J
FAU - Bhat, Hari K
AU  - Bhat HK
LA  - eng
GR  - R01 CA109551/CA/NCI NIH HHS/United States
GR  - CA 109551/CA/NCI NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PT  - Research Support, Non-U.S. Gov't
DEP - 20140806
PL  - United States
TA  - J Biochem Mol Toxicol
JT  - Journal of biochemical and molecular toxicology
JID - 9717231
RN  - 0 (Antioxidants)
RN  - 0 (Basic-Leucine Zipper Transcription Factors)
RN  - 0 (Estrogens)
RN  - 0 (Neoplasm Proteins)
RN  - 4TI98Z838E (Estradiol)
RN  - EC 1.15.1.1 (SOD3 protein, human)
RN  - EC 1.15.1.1 (Superoxide Dismutase)
RN  - EC 1.6.5.2 (NAD(P)H Dehydrogenase (Quinone))
RN  - EC 1.6.5.2 (NQO1 protein, human)
SB  - IM
MH  - Antioxidants/*metabolism
MH  - Basic-Leucine Zipper Transcription Factors/*metabolism
MH  - *Breast Neoplasms/chemically induced/enzymology/pathology/prevention & control
MH  - Cell Line, Tumor
MH  - Estradiol/*adverse effects/pharmacology
MH  - Estrogens/*adverse effects/pharmacology
MH  - Female
MH  - Gene Expression Regulation, Enzymologic/drug effects
MH  - Gene Expression Regulation, Neoplastic/drug effects
MH  - Humans
MH  - NAD(P)H Dehydrogenase (Quinone)/*biosynthesis
MH  - Neoplasm Proteins/*metabolism
MH  - Superoxide Dismutase/*biosynthesis
PMC - PMC4257850
MID - NIHMS618579
OTO - NOTNLM
OT  - Breast Cancer
OT  - CNC b-zip Transcription Factors
OT  - Estrogen
OT  - Resveratrol
OT  - Vitamin C
EDAT- 2014/08/19 06:00
MHDA- 2015/07/15 06:00
PMCR- 2015/12/01
CRDT- 2014/08/19 06:00
PHST- 2014/06/04 00:00 [received]
PHST- 2014/07/01 00:00 [accepted]
PHST- 2014/08/19 06:00 [entrez]
PHST- 2014/08/19 06:00 [pubmed]
PHST- 2015/07/15 06:00 [medline]
PHST- 2015/12/01 00:00 [pmc-release]
AID - 10.1002/jbt.21594 [doi]
PST - ppublish
SO  - J Biochem Mol Toxicol. 2014 Dec;28(12):529-38. doi: 10.1002/jbt.21594. Epub 2014 
      Aug 6.