PMID- 25131160
OWN - NLM
STAT- MEDLINE
DCOM- 20150724
LR  - 20240510
IS  - 1931-8405 (Electronic)
IS  - 0889-2229 (Print)
IS  - 0889-2229 (Linking)
VI  - 30
IP  - 12
DP  - 2014 Dec
TI  - The immune pathogenesis of immune reconstitution inflammatory syndrome associated 
      with highly active antiretroviral therapy in AIDS.
PG  - 1197-202
LID - 10.1089/AID.2014.0106 [doi]
AB  - The present study investigated the immunological pathogenesis of immune 
      reconstitution inflammatory syndrome (IRIS) in acquired immunodeficiency syndrome 
      (AIDS) patients undergoing highly active antiretroviral therapy (HAART). A total 
      of 238 patients with AIDS who received initial HAART were included in this 
      prospective cohort study. Blood samples were collected immediately, at baseline, 
      at week 12, and at week 24 after initial HAART and at the onset of IRIS. 
      Lymphocyte subsets, Th1 and Th2 cytokines, and interleukin (IL)-7 levels were 
      measured by flow cytometry or ELISA. Among the 238 patients with AIDS who 
      received HAART, 47 patients developed IRIS. The percentages of CD4(+) and CD8(+) 
      naive, memory, and activated cells exhibited no significant differences between 
      AIDS patients with and without IRIS 24 weeks after initial HAART. The percentage 
      of CD4(+)CD25(+)Foxp3(+) regulatory T cells was lower in IRIS patients than in 
      non-IRIS patients before HAART, 12 weeks after HAART, 24 weeks after HAART, and 
      at the onset of IRIS. IL-2 and interferon (IFN)-gamma levels were significantly 
      higher at week 4 and at the onset of IRIS in IRIS patients than in non-IRIS 
      patients. In contrast, IL-4 and IL-10 levels were significantly lower at week 4 
      and at the onset of IRIS in IRIS patients than in non-IRIS patients. Plasma IL-7 
      decreased gradually with the progression of HAART. The level of IL-7 was higher 
      in IRIS patients than in non-IRIS patients at all follow-up time points. An 
      imbalance of Th1/Th2 cytokines, a consistently low CD(+)CD25(+)Fox3(+) 
      percentage, and a high IL-7 level may be crucial in the pathogenesis of IRIS in 
      AIDS patients who had received HAART.
FAU - Zheng, Yuhuang
AU  - Zheng Y
AD  - AIDS Laboratory, Department of Infectious Diseases, Second Xiangya Hospital, 
      Central-South University , Changsha, Hunan, People's Republic of China .
FAU - Zhou, Huaying
AU  - Zhou H
FAU - He, Yan
AU  - He Y
FAU - Chen, Zi
AU  - Chen Z
FAU - He, Bo
AU  - He B
FAU - He, Mei
AU  - He M
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - AIDS Res Hum Retroviruses
JT  - AIDS research and human retroviruses
JID - 8709376
RN  - 0 (Anti-HIV Agents)
RN  - 0 (Interleukin-2)
RN  - 0 (Interleukin-7)
RN  - 130068-27-8 (Interleukin-10)
RN  - 207137-56-2 (Interleukin-4)
RN  - 82115-62-6 (Interferon-gamma)
SB  - IM
MH  - Acquired Immunodeficiency Syndrome/*drug therapy
MH  - Adult
MH  - Anti-HIV Agents/administration & dosage/therapeutic use
MH  - Antiretroviral Therapy, Highly Active/*adverse effects
MH  - Female
MH  - Humans
MH  - Immune Reconstitution Inflammatory Syndrome/epidemiology/*etiology
MH  - Interferon-gamma/blood
MH  - Interleukin-10/blood
MH  - Interleukin-2/blood
MH  - Interleukin-4/blood
MH  - Interleukin-7/blood
MH  - Male
MH  - Middle Aged
MH  - Prospective Studies
MH  - Risk Factors
MH  - T-Lymphocyte Subsets/drug effects
MH  - Time Factors
PMC - PMC4250954
EDAT- 2014/08/19 06:00
MHDA- 2015/07/25 06:00
PMCR- 2015/12/01
CRDT- 2014/08/19 06:00
PHST- 2014/08/19 06:00 [entrez]
PHST- 2014/08/19 06:00 [pubmed]
PHST- 2015/07/25 06:00 [medline]
PHST- 2015/12/01 00:00 [pmc-release]
AID - 10.1089/aid.2014.0106 [pii]
AID - 10.1089/AID.2014.0106 [doi]
PST - ppublish
SO  - AIDS Res Hum Retroviruses. 2014 Dec;30(12):1197-202. doi: 10.1089/AID.2014.0106.