PMID- 25131461
OWN - NLM
STAT- MEDLINE
DCOM- 20150908
LR  - 20181202
IS  - 1671-167X (Print)
IS  - 1671-167X (Linking)
VI  - 46
IP  - 4
DP  - 2014 Aug 18
TI  - [Expression of brainderived neurotrophic factor in urine of patients with benign 
      prostatic hyperplasia complicated overactive bladder symptoms].
PG  - 519-23
AB  - OBJECTIVE: To investigate the expression of urinary brainderived neurotrophic 
      factor (BDNF) in benign prostatic hyperplasia patients with overactive bladder 
      (OAB) symptoms and its correlation with the severity of OAB symptoms. METHODS: 
      According to the inclusion and exclusion criteria, a total of 178 patients with 
      benign prostatic hyperplasia who were to undergo transurethral resection of 
      prostate (TURP) were enrolled in this study. All the patients had accepted basic 
      preoperative evaluations, as well as an assessment of their International 
      Prostate Symptom Score (IPSS) and Overactive Bladder Symptom Score (OABSS). The 
      patients who had been scheduled for surgery had to take the urodynamic 
      assessment. Urinary BDNF levels were measured by the enzyme-linked immunosorbent 
      assay (ELISA) and the results were further normalized to the concentration of 
      urinary creatinine (BDNF/Cr, mg/mol). RESULTS: The urinary BDNF/Cr levels of the 
      patients with moderate and severe lower urinary tract symptoms were (1.189 +/- 
      0.753) mg/mol and (1.817 +/- 1.110) mg/mol (P < 0.001). The urinary BDNF/Cr levels 
      of the patients with grades III-VI obstruction were (1.382 +/- 0.945) mg/mol, 
      (1.435 +/- 0.938) mg/mol, (1.640 +/- 1.104) mg/mol, and (1.653 +/- 1.019) mg/mol, 
      respectively (P > 0.05). There was no correlation between the urinary BDNF/Cr 
      levels and the severity of obstruction (r = 0.103, P = 0.173). The urinary 
      BDNF/Cr levels in the patients with and without OAB symptoms were (1.913 +/- 0.843) 
      mg/mol and (0.297 +/- 0.183) mg/mol (P < 0.001). The urinary BDNF/Cr levels in the 
      patients with mild, moderate and severe OAB symptoms were (1.501 +/- 0.543) mg/mol, 
      (1.806 +/- 0.703) mg/mol and (2.560 +/- 0.979) mg/mol, respectively (P < 0.05). There 
      was a correlation between the urinary BDNF/Cr levels and the severity of OAB 
      symptoms (r = 0.743, P < 0.001). The urinary BDNF/Cr levels in the patients with 
      urodynamic detrusor overativity were significantly higher than those without 
      detrusor overativity [(1.917 +/- 0.866) mg/mol and (1.194 +/- 1.013) mg/mol, P < 
      0.001]. CONCLUSION: There is no correlation between urinary BDNF and severity of 
      obstruction in benign prostatic hyperplasia patients with moderate and severe 
      lower urinary tract symptoms. The urinary BDNF levels in patients with OAB 
      symptoms are elevated compared with patients without OAB symptoms, and are 
      correlated with the severity of OAB symptoms.
FAU - Hu, Hao
AU  - Hu H
AD  - Department of Urology, Peking University People's Hospital, Beijing 100044, 
      China.
FAU - Xu, Ke-xin
AU  - Xu KX
AD  - Department of Urology, Peking University People's Hospital, Beijing 100044, 
      China.
FAU - Zhang, Xiao-peng
AU  - Zhang XP
AD  - Department of Urology, Peking University People's Hospital, Beijing 100044, 
      China.
FAU - Fang, Zhi-wei
AU  - Fang ZW
AD  - Department of Urology, Peking University People's Hospital, Beijing 100044, 
      China.
FAU - Chen, Jing-wen
AU  - Chen JW
AD  - Department of Urology, Peking University People's Hospital, Beijing 100044, 
      China.
FAU - Huo, Fei
AU  - Huo F
AD  - Department of Urology, Peking University People's Hospital, Beijing 100044, 
      China.
FAU - Wang, Dong
AU  - Wang D
AD  - Department of Urology, Peking University People's Hospital, Beijing 100044, 
      China.
FAU - Wang, Xiao-feng
AU  - Wang XF
AD  - Department of Urology, Peking University People's Hospital, Beijing 100044, 
      China.
LA  - chi
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - China
TA  - Beijing Da Xue Xue Bao Yi Xue Ban
JT  - Beijing da xue xue bao. Yi xue ban = Journal of Peking University. Health 
      sciences
JID - 101125284
RN  - 0 (Brain-Derived Neurotrophic Factor)
RN  - 7171WSG8A2 (BDNF protein, human)
RN  - AYI8EX34EU (Creatinine)
SB  - IM
MH  - Brain-Derived Neurotrophic Factor/*urine
MH  - Creatinine/urine
MH  - Enzyme-Linked Immunosorbent Assay
MH  - Humans
MH  - Lower Urinary Tract Symptoms/*metabolism
MH  - Male
MH  - Prostatic Hyperplasia/*metabolism
MH  - Urinary Bladder, Overactive/*metabolism
MH  - Urodynamics
EDAT- 2014/08/19 06:00
MHDA- 2015/09/09 06:00
CRDT- 2014/08/19 06:00
PHST- 2014/08/19 06:00 [entrez]
PHST- 2014/08/19 06:00 [pubmed]
PHST- 2015/09/09 06:00 [medline]
PST - ppublish
SO  - Beijing Da Xue Xue Bao Yi Xue Ban. 2014 Aug 18;46(4):519-23.