PMID- 25131580
OWN - NLM
STAT- MEDLINE
DCOM- 20160620
LR  - 20221207
IS  - 1098-2825 (Electronic)
IS  - 0887-8013 (Print)
IS  - 0887-8013 (Linking)
VI  - 29
IP  - 5
DP  - 2015 Sep
TI  - Enhanced RBC Aggregation in Type 2 Diabetes Patients.
PG  - 387-9
LID - 10.1002/jcla.21784 [doi]
AB  - BACKGROUND: This study aimed to investigate the relationship between HbA1c and 
      RBC aggregation in type 2 diabetes mellitus (T2DM) patients by analysis of data 
      from routine clinical tests and from in vitro experiments. METHODS: A total of 
      2,111 inpatients with type 2 diabetes were selected and among them, 364 patients 
      (Group A) had limited influence of plasma proteins on erythrocyte sedimentation 
      rate (ESR) and was compared with the rest of the 1,747 inpatients (Group B). ESR, 
      HbA1c , WBC, CRP, Fbg, and HCT were measured in all samples. Sixty samples were 
      also collected from T2DM patients and used for in vitro ESR studies. Spearman's 
      correlation coefficients were employed to reflect the correlation between ESR and 
      other parameters. Mann-Whitney U test was used to compare the study parameters. 
      RESULTS: The test results for Group A were lower than Group B with respect to 
      ESR, age, HCT, HbA1c , CRP, WBC, and Fbg. Only the difference in HbA1c , CRP, and 
      Fbg values had statistical significance (P < 0.05). In addition, HbA1c correlated 
      better with ESR for Group A (R = 0.622) than Group B (R = 0.563), whereas CRP and 
      Fbg were contrary to this. In the in vitro studies, the HbA1c values were 
      classified into the subgroups of 6.5-8.0%, 8.1-10%, and >10%. The corresponding 
      ESR values were 28 +/- 5.1 mm/h, 33 +/- 2.7 mm/h, and 40 +/- 4.1 mm/h, respectively. 
      CONCLUSION: ESR results of T2DM patients were elevated that was mainly caused by 
      Fbg levels, and in addition HbA1c in part contributed to RBC aggregation.
CI  - (c) 2014 Wiley Periodicals, Inc.
FAU - Li, Qing
AU  - Li Q
AD  - Shanghai Center for Clinical Laboratory, Shanghai, China.
FAU - Li, Li
AU  - Li L
AD  - Yueyang Hospital of Integrated Traditional Chinese and Western Medicine, 
      Shanghai, China.
FAU - Li, Yong
AU  - Li Y
AD  - Shanghai Center for Clinical Laboratory, Shanghai, China.
LA  - eng
PT  - Journal Article
DEP - 20140817
PL  - United States
TA  - J Clin Lab Anal
JT  - Journal of clinical laboratory analysis
JID - 8801384
RN  - 0 (Glycated Hemoglobin A)
RN  - 0 (hemoglobin A1c protein, human)
RN  - 9007-41-4 (C-Reactive Protein)
SB  - IM
MH  - Adult
MH  - Blood Sedimentation
MH  - C-Reactive Protein/analysis
MH  - Diabetes Mellitus, Type 2/blood/epidemiology/*physiopathology
MH  - Erythrocyte Aggregation/*physiology
MH  - Glycated Hemoglobin/analysis
MH  - Humans
MH  - Middle Aged
MH  - Retrospective Studies
PMC - PMC6806712
OTO - NOTNLM
OT  - HbA1c
OT  - RBC aggregation
OT  - T2DM
OT  - erythrocyte sedimentation rate
EDAT- 2014/08/19 06:00
MHDA- 2016/06/21 06:00
PMCR- 2014/08/17
CRDT- 2014/08/19 06:00
PHST- 2013/10/13 00:00 [received]
PHST- 2014/05/21 00:00 [accepted]
PHST- 2014/08/19 06:00 [entrez]
PHST- 2014/08/19 06:00 [pubmed]
PHST- 2016/06/21 06:00 [medline]
PHST- 2014/08/17 00:00 [pmc-release]
AID - JCLA21784 [pii]
AID - 10.1002/jcla.21784 [doi]
PST - ppublish
SO  - J Clin Lab Anal. 2015 Sep;29(5):387-9. doi: 10.1002/jcla.21784. Epub 2014 Aug 17.