PMID- 25131687
OWN - NLM
STAT- MEDLINE
DCOM- 20160720
LR  - 20220321
IS  - 1399-5448 (Electronic)
IS  - 1399-543X (Linking)
VI  - 16
IP  - 7
DP  - 2015 Nov
TI  - Prevalence of celiac disease autoimmunity in children with type 1 diabetes: 
      regional variations across the Oresund strait between Denmark and southernmost 
      Sweden.
PG  - 504-9
LID - 10.1111/pedi.12200 [doi]
AB  - OBJECTIVES: The aim was to determine the prevalence of celiac disease 
      autoimmunity in children with type 1 diabetes (T1D) diagnosed in Denmark and 
      Sweden. METHODS: A total of 662 Swedish children with T1D were matched with 1080 
      Danish children with T1D and 309 healthy children from Sweden and 283 from 
      Denmark served as controls. Sera were analyzed for the presence of IgA and IgG 
      (IgAG) autoantibodies against deamidated gliadin peptide (DGP) and tissue 
      transglutaminase (tTG) with enzyme-linked immunosorbent assay (ELISA) and IgG-tTG 
      separately in a radioligand binding assay (RBA). Human leukocyte antigen 
      (HLA)-DQB1 and DQA1 genotyping were determined in the T1D cohorts. RESULTS: In 
      the Swedish T1D cohort, 17.2% (114/662) were IgAG-DGP/tTG positive compared with 
      11.7% (126/1080) in the Danish T1D cohort (p = 0.001) and with 9.4% (29/309) 
      Swedish (p = 0.001) and 5.7% (16/283) Danish (p = 0.003) controls. In the Swedish 
      T1D cohort, both levels of IgAG-DGP/tTG and IgG-tTG were higher compared with the 
      levels in the Danish T1D (p < 0.001). In the control group, 2.8% of the Danish 
      children were positive for both IgAG-DGP/tTG and IgG-tTG, compared to 0.3% of the 
      Swedish. Presence of HLA-DQ2 was equally distributed among 89 children with T1D 
      positive for both IgAG-DGP/tTG and IgG-tTG. CONCLUSION: The discrepancy in levels 
      of IgAG-DGP/tTG and IgG-tTG between Swedish and Danish T1D cohorts was 
      independent of HLA and suggests that regional variations in comorbidity of celiac 
      disease in T1D is caused by difference in exposure to environmental factors.
CI  - (c) 2014 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd.
FAU - Adlercreutz, Emma H
AU  - Adlercreutz EH
AD  - Department of Clinical Sciences, Skane University Hospital SUS, Lund 
      University/CRC, Malmo, Sweden.
FAU - Svensson, Jannet
AU  - Svensson J
AD  - Department of Paediatrics, Herlev Hospital, Herlev, Denmark.
AD  - Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, 
      Denmark.
FAU - Hansen, Dorthe
AU  - Hansen D
AD  - Department of Paediatrics, Odense University Hospital, Odense, Denmark.
FAU - Buschard, Karsten
AU  - Buschard K
AD  - The Bartholin Institute, Rigshospitalet, Copenhagen, Denmark.
FAU - Lernmark, Ake
AU  - Lernmark A
AD  - Department of Clinical Sciences, Skane University Hospital SUS, Lund 
      University/CRC, Malmo, Sweden.
FAU - Mortensen, Henrik Bindesbol
AU  - Mortensen HB
AD  - Department of Paediatrics, Herlev Hospital, Herlev, Denmark.
AD  - Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, 
      Denmark.
FAU - Agardh, Daniel
AU  - Agardh D
AD  - Department of Clinical Sciences, Skane University Hospital SUS, Lund 
      University/CRC, Malmo, Sweden.
LA  - eng
PT  - Comparative Study
PT  - Journal Article
DEP - 20140818
PL  - Denmark
TA  - Pediatr Diabetes
JT  - Pediatric diabetes
JID - 100939345
RN  - 0 (Autoantibodies)
RN  - 0 (Immunoglobulin A)
RN  - 0 (Immunoglobulin G)
RN  - 0 (Peptide Fragments)
RN  - 9007-90-3 (Gliadin)
RN  - EC 2.3.2.13 (Protein Glutamine gamma Glutamyltransferase 2)
RN  - EC 2.3.2.13 (Transglutaminases)
RN  - EC 3.6.1.- (GTP-Binding Proteins)
SB  - IM
MH  - Adolescent
MH  - Autoantibodies/*analysis
MH  - *Autoimmunity
MH  - Celiac Disease/blood/complications/epidemiology/*immunology
MH  - Child
MH  - Child, Preschool
MH  - Cohort Studies
MH  - Denmark/epidemiology
MH  - Diabetes Mellitus, Type 1/blood/complications/*immunology
MH  - Female
MH  - GTP-Binding Proteins/*antagonists & inhibitors
MH  - Gliadin/*antagonists & inhibitors/chemistry
MH  - Humans
MH  - Immunoglobulin A/analysis
MH  - Immunoglobulin G/analysis
MH  - Infant
MH  - Male
MH  - Peptide Fragments/antagonists & inhibitors/metabolism
MH  - Prevalence
MH  - Protein Glutamine gamma Glutamyltransferase 2
MH  - Retrospective Studies
MH  - Risk
MH  - Sweden/epidemiology
MH  - Transglutaminases/*antagonists & inhibitors
OTO - NOTNLM
OT  - T1D
OT  - celiac disease
EDAT- 2014/08/19 06:00
MHDA- 2016/07/21 06:00
CRDT- 2014/08/19 06:00
PHST- 2014/02/26 00:00 [received]
PHST- 2014/06/07 00:00 [revised]
PHST- 2014/07/01 00:00 [accepted]
PHST- 2014/08/19 06:00 [entrez]
PHST- 2014/08/19 06:00 [pubmed]
PHST- 2016/07/21 06:00 [medline]
AID - 10.1111/pedi.12200 [doi]
PST - ppublish
SO  - Pediatr Diabetes. 2015 Nov;16(7):504-9. doi: 10.1111/pedi.12200. Epub 2014 Aug 
      18.