PMID- 25132151
OWN - NLM
STAT- MEDLINE
DCOM- 20150731
LR  - 20141206
IS  - 1878-4216 (Electronic)
IS  - 0278-5846 (Linking)
VI  - 56
DP  - 2015 Jan 2
TI  - Brain derived neurotrophic factor gene (BDNF) and personality traits: the 
      modifying effect of season of birth and sex.
PG  - 58-65
LID - S0278-5846(14)00151-1 [pii]
LID - 10.1016/j.pnpbp.2014.08.001 [doi]
AB  - Personality traits are complex phenotypes influenced by interactions of multiple 
      genetic variants of small effect and environmental factors. It has been suggested 
      that the brain derived neurotrophic factor gene (BDNF) is involved in personality 
      traits. Season of birth (SOB) has also been shown to affect personality traits 
      due to its influences on brain development during prenatal and early postnatal 
      periods. The present study aimed to investigate the effects of BDNF on 
      personality traits; and the modifying effects of SOB and sex on associations 
      between BDNF and personality traits. A sample of 1018 young adults (68% women; 
      age range 17-25years) of Caucasian origin from the Russian Federation was 
      assessed on personality traits (Novelty Seeking, Harm Avoidance, Reward 
      Dependence, Persistence, Self-directedness, Cooperativeness, Self-transcendence) 
      with the Temperament and Character Inventory-125 (TCI-125). Associations between 
      personality traits and 12 BDNF SNPs were tested using linear regression models. 
      The present study demonstrated the effect of rs11030102 on Persistence in females 
      only (PFDR=0.043; r(2)=1.3%). There were significant interaction effects between 
      Val66Met (rs6265) and SOB (PFDR=0.048, r(2)=1.4%), and between rs2030323 and SOB 
      (PFDR=0.042, r(2)=1.3%), on Harm Avoidance. Our findings provide evidence for the 
      modifying effect of SOB on the association between BDNF and Harm Avoidance, and 
      for the modifying effect of sex on the association between BDNF and Persistence.
CI  - Copyright (c) 2014 Elsevier Inc. All rights reserved.
FAU - Kazantseva, A
AU  - Kazantseva A
AD  - Institute of Biochemistry and Genetics, Ufa Scientific Center, Russian Academy of 
      Sciences, 71, Prospekt Oktyabrya, Ufa 450054, Russia. Electronic address: 
      Kazantsa@mail.ru.
FAU - Gaysina, D
AU  - Gaysina D
AD  - Rudd Centre for Adoption Research and Practice, School of Psychology, University 
      of Sussex, Falmer, Brighton BN1 9RH, United Kingdom. Electronic address: 
      D.Gaysina@sussex.ac.uk.
FAU - Kutlumbetova, Yu
AU  - Kutlumbetova Y
AD  - Institute of Biochemistry and Genetics, Ufa Scientific Center, Russian Academy of 
      Sciences, 71, Prospekt Oktyabrya, Ufa 450054, Russia; Bashkir State University, 
      32, Zaki Validi, Ufa 450074, Russia. Electronic address: suleimanovaulia@mail.ru.
FAU - Kanzafarova, R
AU  - Kanzafarova R
AD  - Institute of Biochemistry and Genetics, Ufa Scientific Center, Russian Academy of 
      Sciences, 71, Prospekt Oktyabrya, Ufa 450054, Russia; Bashkir State University, 
      32, Zaki Validi, Ufa 450074, Russia.
FAU - Malykh, S
AU  - Malykh S
AD  - Psychological Institute, Russian Academy of Education, 9/4, Mohovaya Street, 
      Moscow 125009, Russia. Electronic address: malykhsb@mail.ru.
FAU - Lobaskova, M
AU  - Lobaskova M
AD  - Udmurt State University, Universitetskaya St. 1Izhevsk, 426034, Russia.
FAU - Khusnutdinova, E
AU  - Khusnutdinova E
AD  - Institute of Biochemistry and Genetics, Ufa Scientific Center, Russian Academy of 
      Sciences, 71, Prospekt Oktyabrya, Ufa 450054, Russia; Rudd Centre for Adoption 
      Research and Practice, School of Psychology, University of Sussex, Falmer, 
      Brighton BN1 9RH, United Kingdom.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20140815
PL  - England
TA  - Prog Neuropsychopharmacol Biol Psychiatry
JT  - Progress in neuro-psychopharmacology & biological psychiatry
JID - 8211617
RN  - 0 (Brain-Derived Neurotrophic Factor)
RN  - AE28F7PNPL (Methionine)
RN  - HG18B9YRS7 (Valine)
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - Brain-Derived Neurotrophic Factor/*genetics
MH  - Female
MH  - Genotype
MH  - Humans
MH  - Male
MH  - Methionine/genetics
MH  - Personality/*genetics
MH  - Personality Inventory
MH  - Polymorphism, Single Nucleotide/*genetics
MH  - *Seasons
MH  - *Sex Characteristics
MH  - Valine/genetics
MH  - Young Adult
OTO - NOTNLM
OT  - Effect modification
OT  - Gene-environment interaction
OT  - Neuroticism
OT  - Polymorphism
OT  - Prenatal effect
OT  - SNP
EDAT- 2014/08/19 06:00
MHDA- 2015/08/01 06:00
CRDT- 2014/08/19 06:00
PHST- 2014/03/07 00:00 [received]
PHST- 2014/07/16 00:00 [revised]
PHST- 2014/08/04 00:00 [accepted]
PHST- 2014/08/19 06:00 [entrez]
PHST- 2014/08/19 06:00 [pubmed]
PHST- 2015/08/01 06:00 [medline]
AID - S0278-5846(14)00151-1 [pii]
AID - 10.1016/j.pnpbp.2014.08.001 [doi]
PST - ppublish
SO  - Prog Neuropsychopharmacol Biol Psychiatry. 2015 Jan 2;56:58-65. doi: 
      10.1016/j.pnpbp.2014.08.001. Epub 2014 Aug 15.