PMID- 25132194
OWN - NLM
STAT- MEDLINE
DCOM- 20150826
LR  - 20160831
IS  - 1442-9071 (Electronic)
IS  - 1442-6404 (Linking)
VI  - 43
IP  - 2
DP  - 2015 Mar
TI  - Twenty-four-hour intraocular pressure patterns in patients with thyroid eye 
      disease.
PG  - 108-14
LID - 10.1111/ceo.12400 [doi]
AB  - BACKGROUND: To prospectively investigate the safety, tolerability and 24-h 
      intraocular pressure (IOP) patterns in patients with thyroid eye disease (TED) 
      using a contact lens sensor (CLS). DESIGN: Prospective study. PARTICIPANTS: Ten 
      patients with established TED. METHODS: Ten eyes of 10 patients were 
      prospectively evaluated in an ambulatory 24-h IOP monitoring session using the 
      CLS (Sensimed AG, Lausanne, Switzerland). Patients pursued daily activities, and 
      sleep behaviour was uncontrolled. MAIN OUTCOME MEASURES: Incidence of adverse 
      events (AEs) and tolerability (scale of 0-10, increasing intolerance) were 
      assessed. IOP patterns were evaluated using a cosinor rhythmometry model, and 
      linear regression slopes were constructed for the transition from wake/sitting 
      (W/S) to sleep/supine (S/S) and vice versa. RESULTS: Mean age was 61.8 +/- 21.6 
      years, and 90% of patients were female. Main AEs were blurred vision (50%), 
      conjunctival hyperaemia (100%) and superficial punctate keratitis (20%). 
      Tolerability of the lens was found to be 1.5 +/- 0.7. Positive linear slopes of the 
      CLS signal from wake to sleep were detected (18.0 +/- 43.8 arbitrary units [a.u.]; 
      P = 0.254), whereas at the transition from S/S to W/S a significant decrease 
      (-62.9 +/- 56.8 a.u.; P = 0.010) was found. Five patients (50%) had a significant 
      nocturnal/sleep acrophase with the peak occurring at 6:30 a.m. The mean amplitude 
      of the 24-h curves was 102.2 +/- 52.6 a.u. CONCLUSIONS: In patients with TED, the 
      CLS provides a safe and well-tolerated approach to 24-h IOP monitoring. After 
      modelling the 24-h IOP curves, TED patients were found to have a morning 
      acrophase.
CI  - (c) 2014 Royal Australian and New Zealand College of Ophthalmologists.
FAU - Parekh, Anjali S
AU  - Parekh AS
AD  - Hamilton Glaucoma Center, Shiley Eye Center, University of California, San Diego, 
      La Jolla, California, USA.
FAU - Mansouri, Kaweh
AU  - Mansouri K
FAU - Weinreb, Robert N
AU  - Weinreb RN
FAU - Tafreshi, Ali
AU  - Tafreshi A
FAU - Korn, Bobby S
AU  - Korn BS
FAU - Kikkawa, Don O
AU  - Kikkawa DO
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20140929
PL  - Australia
TA  - Clin Exp Ophthalmol
JT  - Clinical & experimental ophthalmology
JID - 100896531
SB  - IM
MH  - Adult
MH  - Aged
MH  - Aged, 80 and over
MH  - Circadian Rhythm/*physiology
MH  - Female
MH  - Graves Ophthalmopathy/*physiopathology
MH  - Humans
MH  - Intraocular Pressure/*physiology
MH  - Male
MH  - Middle Aged
MH  - Monitoring, Ambulatory/*instrumentation
MH  - Prospective Studies
MH  - Reproducibility of Results
MH  - Tonometry, Ocular/*instrumentation
MH  - Young Adult
OTO - NOTNLM
OT  - contact lens sensor
OT  - glaucoma
OT  - intraocular pressure
OT  - thyroid eye disease
EDAT- 2014/08/19 06:00
MHDA- 2015/08/27 06:00
CRDT- 2014/08/19 06:00
PHST- 2013/12/14 00:00 [received]
PHST- 2014/07/15 00:00 [accepted]
PHST- 2014/08/19 06:00 [entrez]
PHST- 2014/08/19 06:00 [pubmed]
PHST- 2015/08/27 06:00 [medline]
AID - 10.1111/ceo.12400 [doi]
PST - ppublish
SO  - Clin Exp Ophthalmol. 2015 Mar;43(2):108-14. doi: 10.1111/ceo.12400. Epub 2014 Sep 
      29.