PMID- 25132488
OWN - NLM
STAT- MEDLINE
DCOM- 20151015
LR  - 20140904
IS  - 1096-9071 (Electronic)
IS  - 0146-6615 (Linking)
VI  - 86
IP  - 11
DP  - 2014 Nov
TI  - Characterization of overt and occult hepatitis B virus infection among HTLV-1 
      positive healthy carriers in the Northeast of Iran; AN HTLV-I endemic area.
PG  - 1861-7
LID - 10.1002/jmv.24046 [doi]
AB  - To date, no studies have provided data on hepatitis B virus (HBV) prevalence 
      among asymptomatic, healthy human T-lymphotropic virus (HTLV-I) positive 
      carriers. This sero- and molecular epidemiology study was performed on patients 
      in the Northeast of Iran, which is an endemic area for HTLV-I infection. A total 
      of 109 sera were collected from HTLV-I positive healthy carriers who were 
      admitted to Ghaem Hospital, Mashhad City. All were tested for HBV serology and 
      subsequently, real time PCR was carried out on the samples, regardless of the 
      results of the serology. Standard PCR and direct sequencing were applied on 
      positive samples. All cases were negative for HBsAg, Anti-HBc, and anti-HBs were 
      positive in 34 (31.1%), and 35 (32%) individuals, respectively. There were 19 
      (17.4%) cases that were positive only for anti-HBs, and they had already received 
      HBV vaccine. 16 (15%) were positive for both anti-HBs and anti-HBc, indicating a 
      past-resolved HBV infection. 18 (16.5%) were isolated as anti-HBc, and 56 (51.3%) 
      were negative for all HBV serological markers. Only one subject (0.9%) had 
      detectable HBV DNA (2153 copy/ml), and assigned as being an occult HBV infection. 
      The low prevalence of HBsAg, despite the high percentage of anti-HBc positive 
      cases, might be related to the suppression effect of HTLV-I on surface protein 
      expression. The low prevalence of HBV infection among HTLV-I positive healthy 
      carriers from an endemic region, indicates that the epidemiology of HTLV-I and 
      HBV coinfection is related to the endemicity of HBV in that region, rather than 
      HTLV-I endemicity.
CI  - (c) 2014 Wiley Periodicals, Inc.
FAU - Chenari, Maryam
AU  - Chenari M
AD  - Hepatitis B Molecular Laboratory, Department of Virology, School of Public 
      Health, Tehran University of Medical Sciences, Tehran, Iran.
FAU - Norouzi, Mehdy
AU  - Norouzi M
FAU - Ghalichi, Leila
AU  - Ghalichi L
FAU - Rezaee, Abdolrahim
AU  - Rezaee A
FAU - Yari, Atefe
AU  - Yari A
FAU - Alavian, Seyed Moayed
AU  - Alavian SM
FAU - Jazayeri, Seyed Mohammad
AU  - Jazayeri SM
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20140813
PL  - United States
TA  - J Med Virol
JT  - Journal of medical virology
JID - 7705876
RN  - 0 (DNA, Viral)
RN  - 0 (Hepatitis B Antibodies)
RN  - 0 (Hepatitis B Core Antigens)
RN  - 0 (Hepatitis B Surface Antigens)
SB  - IM
MH  - Adult
MH  - Aged
MH  - Carrier State/*epidemiology/*virology
MH  - Coinfection/*epidemiology
MH  - DNA, Viral/blood/chemistry/genetics
MH  - Female
MH  - HTLV-I Infections/*complications/*epidemiology
MH  - Hepatitis B/*complications/*epidemiology
MH  - Hepatitis B Antibodies/blood
MH  - Hepatitis B Core Antigens/blood
MH  - Hepatitis B Surface Antigens/blood
MH  - Hepatitis B virus/isolation & purification
MH  - Humans
MH  - Iran/epidemiology
MH  - Male
MH  - Middle Aged
MH  - Polymerase Chain Reaction
MH  - Sequence Analysis, DNA
OTO - NOTNLM
OT  - ATL
OT  - HAM/TSP
OT  - HBV
OT  - HTLV-I
OT  - coinfection
EDAT- 2014/08/19 06:00
MHDA- 2015/10/16 06:00
CRDT- 2014/08/19 06:00
PHST- 2014/07/15 00:00 [accepted]
PHST- 2014/08/19 06:00 [entrez]
PHST- 2014/08/19 06:00 [pubmed]
PHST- 2015/10/16 06:00 [medline]
AID - 10.1002/jmv.24046 [doi]
PST - ppublish
SO  - J Med Virol. 2014 Nov;86(11):1861-7. doi: 10.1002/jmv.24046. Epub 2014 Aug 13.