PMID- 25132678
OWN - NLM
STAT- MEDLINE
DCOM- 20150611
LR  - 20220330
IS  - 2042-6984 (Electronic)
IS  - 2042-6976 (Linking)
VI  - 4
IP  - 10
DP  - 2014 Oct
TI  - Chronic rhinosinusitis patients have decreased lung function.
PG  - 828-33
LID - 10.1002/alr.21370 [doi]
AB  - BACKGROUND: The relationship between upper and lower airway diseases has been 
      reported. However, the pulmonary function of patients with chronic rhinosinusitis 
      (CRS) has not been fully examined. METHODS: Pulmonary function was measured in 
      273 patients with CRS and 100 age-matched normal control subjects. No patients 
      with chronic obstructive pulmonary disease (COPD) were included in this study. 
      The patients with CRS were divided into 8 subgroups based on the presence of 
      asthma, sensitization to common inhaled antigens, and nasal polyposis. The 
      relationships between pulmonary function and clinical parameters, including 
      radiographic severity of CRS according to the Lund-Mackay computed tomography 
      (CT) staging system, eosinophil count in the peripheral blood, and serum total 
      immunoglobulin E (IgE) levels, were assessed. RESULTS: In pulmonary function 
      testing, the CRS patients had affected pulmonary function. The CRS patients 
      without asthma showed latent obstructive pulmonary function changes when compared 
      to normal controls. No significant correlations were observed between pulmonary 
      function and any clinical parameters (Lund-Mackay CT staging score, eosinophil 
      count in the peripheral blood, and serum total IgE levels). CONCLUSION: CRS 
      patients had significant obstructive lung function changes regardless of the 
      presence of asthma. The patients with CRS who had not been clinically diagnosed 
      as having lower respiratory tract diseases might have had subclinical lower 
      airway diseases. Therefore, clinicians should be aware of pulmonary function and 
      lower lung diseases in patients with CRS.
CI  - (c) 2014 ARS-AAOA, LLC.
FAU - Kariya, Shin
AU  - Kariya S
AD  - Department of Otolaryngology-Head and Neck Surgery, Okayama University Graduate 
      School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama, Japan.
FAU - Okano, Mitsuhiro
AU  - Okano M
FAU - Higaki, Takaya
AU  - Higaki T
FAU - Noyama, Yasuyuki
AU  - Noyama Y
FAU - Haruna, Takenori
AU  - Haruna T
FAU - Ishihara, Hisashi
AU  - Ishihara H
FAU - Makino, Takuma
AU  - Makino T
FAU - Onoda, Tomoo
AU  - Onoda T
FAU - Nishizaki, Kazunori
AU  - Nishizaki K
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20140813
PL  - United States
TA  - Int Forum Allergy Rhinol
JT  - International forum of allergy & rhinology
JID - 101550261
RN  - 37341-29-0 (Immunoglobulin E)
SB  - IM
CIN - Allergol Int. 2020 Jan;69(1):144-145. PMID: 31495652
MH  - Adult
MH  - Aged
MH  - Airway Obstruction/physiopathology
MH  - Chronic Disease
MH  - Female
MH  - Humans
MH  - Immunoglobulin E/blood
MH  - Leukocyte Count
MH  - Lung/*physiopathology
MH  - Male
MH  - Middle Aged
MH  - Respiratory Function Tests
MH  - Rhinitis/*physiopathology
MH  - Severity of Illness Index
MH  - Sinusitis/*physiopathology
MH  - Tomography, X-Ray Computed
OTO - NOTNLM
OT  - asthma
OT  - chronic obstructive pulmonary disease
OT  - pulmonary function
OT  - rhinitis
OT  - sinusitis
EDAT- 2014/08/19 06:00
MHDA- 2015/06/13 06:00
CRDT- 2014/08/19 06:00
PHST- 2014/04/12 00:00 [received]
PHST- 2014/06/07 00:00 [revised]
PHST- 2014/06/10 00:00 [accepted]
PHST- 2014/08/19 06:00 [entrez]
PHST- 2014/08/19 06:00 [pubmed]
PHST- 2015/06/13 06:00 [medline]
AID - 10.1002/alr.21370 [doi]
PST - ppublish
SO  - Int Forum Allergy Rhinol. 2014 Oct;4(10):828-33. doi: 10.1002/alr.21370. Epub 
      2014 Aug 13.