PMID- 25132684
OWN - NLM
STAT- MEDLINE
DCOM- 20150803
LR  - 20161125
IS  - 1097-0339 (Electronic)
IS  - 1097-0339 (Linking)
VI  - 43
IP  - 4
DP  - 2015 Apr
TI  - Ultrasound-guided fine-needle aspiration of a posterior neck dedifferentiated 
      liposarcoma with MDM2 fluorescence in situ hybridization performed on a 
      Pap-stained smear.
PG  - 320-4
LID - 10.1002/dc.23200 [doi]
AB  - Head and neck liposarcomas, while rare, tend to be subcutaneous and 
      well-differentiated. Dedifferentiated liposarcomas of the head and neck are 
      exceedingly rare in the literature. We present a case of a dedifferentiated 
      liposarcoma arising in the soft tissue of the posterior neck of an 86-year-old 
      man and diagnosed by fine-needle aspiration. Aspirate smears showed a dual 
      population of atypical lipomatous and spindled cells. MDM2 (murine double minute 
      2) amplification was demonstrated on a Pap-stained smear using fluorescence in 
      situ hybridization (FISH). To the best of our knowledge, this is the first report 
      of MDM2 FISH amplification in a liposarcoma performed on an aspirate smear.
CI  - (c) 2014 Wiley Periodicals, Inc.
FAU - Zreik, Riyam
AU  - Zreik R
AD  - Department of Pathology, Baylor Scott & White and Texas A&M, Temple, Texas.
FAU - Soyalp, Krystal
AU  - Soyalp K
FAU - Ruiz, Steve
AU  - Ruiz S
FAU - Ward, Russell
AU  - Ward R
FAU - Dobin, Sheila
AU  - Dobin S
FAU - Chen, Xiangbai
AU  - Chen X
FAU - Liu, Lina
AU  - Liu L
FAU - Rao, Arundhati
AU  - Rao A
LA  - eng
PT  - Case Reports
PT  - Journal Article
DEP - 20140731
PL  - United States
TA  - Diagn Cytopathol
JT  - Diagnostic cytopathology
JID - 8506895
RN  - EC 2.3.2.27 (MDM2 protein, human)
RN  - EC 2.3.2.27 (Proto-Oncogene Proteins c-mdm2)
SB  - IM
MH  - Aged, 80 and over
MH  - Endoscopic Ultrasound-Guided Fine Needle Aspiration/methods
MH  - Gene Amplification
MH  - Head and Neck Neoplasms/diagnostic imaging/genetics/*pathology
MH  - Humans
MH  - In Situ Hybridization, Fluorescence/methods
MH  - Liposarcoma/diagnostic imaging/genetics/*pathology
MH  - Male
MH  - Papanicolaou Test
MH  - Proto-Oncogene Proteins c-mdm2/*genetics
OTO - NOTNLM
OT  - MDM2
OT  - dedifferentiated liposarcoma
OT  - fine needle aspiration
OT  - fluorescence in situ hybridization
OT  - head and neck
OT  - posterior neck
EDAT- 2014/08/19 06:00
MHDA- 2015/08/04 06:00
CRDT- 2014/08/19 06:00
PHST- 2014/06/03 00:00 [received]
PHST- 2014/07/17 00:00 [accepted]
PHST- 2014/08/19 06:00 [entrez]
PHST- 2014/08/19 06:00 [pubmed]
PHST- 2015/08/04 06:00 [medline]
AID - 10.1002/dc.23200 [doi]
PST - ppublish
SO  - Diagn Cytopathol. 2015 Apr;43(4):320-4. doi: 10.1002/dc.23200. Epub 2014 Jul 31.