PMID- 25132853
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20140818
LR  - 20211021
IS  - 1687-8337 (Print)
IS  - 1687-8345 (Electronic)
IS  - 1687-8337 (Linking)
VI  - 2014
DP  - 2014
TI  - FBP1 Is an Interacting Partner of Menin.
PG  - 535401
LID - 10.1155/2014/535401 [doi]
LID - 535401
AB  - Multiple endocrine neoplasia type 1 (MEN1) is a syndrome characterized by tumors 
      in multiple endocrine tissues such as the parathyroid glands, the pituitary 
      gland, and the enteropancreatic neuroendocrine tissues. MEN1 is usually caused by 
      mutations in the MEN1 gene that codes for the protein menin. Menin interacts with 
      proteins that regulate transcription, DNA repair and processing, and maintenance 
      of cytoskeletal structure. We describe the identification of FBP1 as an 
      interacting partner of menin in a large-scale pull-down assay that also 
      immunoprecipitated RBBP5, ASH2, and LEDGF, which are members of complex proteins 
      associated with SET1 (COMPASS), a protein complex that methylates histone H3. 
      This interaction was confirmed by coimmunoprecipitation and Flag-pull-down 
      assays. Furthermore, menin localized to the FUSE site on the MYC promoter, a site 
      that is transactivated by FBP1. This investigation therefore places menin in a 
      pathway that regulates MYC gene expression and has important implications for the 
      biological function of menin.
FAU - Zaman, Shadia
AU  - Zaman S
AUID- ORCID: 0000-0001-6371-0032
AD  - Metabolic Diseases Branch, National Institute of Diabetes and Digestive and 
      Kidney Diseases, NIH, Building 10, Room 9C-103, 9000 Rockville, Bethesda, MD 
      20892, USA.
FAU - Sukhodolets, Karen
AU  - Sukhodolets K
AD  - Metabolic Diseases Branch, National Institute of Diabetes and Digestive and 
      Kidney Diseases, NIH, Building 10, Room 9C-103, 9000 Rockville, Bethesda, MD 
      20892, USA.
FAU - Wang, Patricia
AU  - Wang P
AUID- ORCID: 0000-0002-6870-6646
AD  - Metabolic Diseases Branch, National Institute of Diabetes and Digestive and 
      Kidney Diseases, NIH, Building 10, Room 9C-103, 9000 Rockville, Bethesda, MD 
      20892, USA.
FAU - Qin, Jun
AU  - Qin J
AD  - Departments of Biochemistry & Molecular Biology and Molecular & Cellular Biology, 
      Baylor College of Medicine, Houston, TX 77030, USA.
FAU - Levens, David
AU  - Levens D
AD  - Laboratory of Pathology, National Cancer Institute, NIH, Bethesda, MD 20892, USA.
FAU - Agarwal, Sunita K
AU  - Agarwal SK
AD  - Metabolic Diseases Branch, National Institute of Diabetes and Digestive and 
      Kidney Diseases, NIH, Building 10, Room 9C-103, 9000 Rockville, Bethesda, MD 
      20892, USA.
FAU - Marx, Stephen J
AU  - Marx SJ
AD  - Metabolic Diseases Branch, National Institute of Diabetes and Digestive and 
      Kidney Diseases, NIH, Building 10, Room 9C-103, 9000 Rockville, Bethesda, MD 
      20892, USA.
LA  - eng
PT  - Journal Article
DEP - 20140714
PL  - Egypt
TA  - Int J Endocrinol
JT  - International journal of endocrinology
JID - 101516376
PMC - PMC4123598
EDAT- 2014/08/19 06:00
MHDA- 2014/08/19 06:01
PMCR- 2014/07/14
CRDT- 2014/08/19 06:00
PHST- 2014/04/29 00:00 [received]
PHST- 2014/06/30 00:00 [revised]
PHST- 2014/07/01 00:00 [accepted]
PHST- 2014/08/19 06:00 [entrez]
PHST- 2014/08/19 06:00 [pubmed]
PHST- 2014/08/19 06:01 [medline]
PHST- 2014/07/14 00:00 [pmc-release]
AID - 10.1155/2014/535401 [doi]
PST - ppublish
SO  - Int J Endocrinol. 2014;2014:535401. doi: 10.1155/2014/535401. Epub 2014 Jul 14.