PMID- 25133649
OWN - NLM
STAT- MEDLINE
DCOM- 20150609
LR  - 20140919
IS  - 1878-1705 (Electronic)
IS  - 1567-5769 (Linking)
VI  - 22
IP  - 2
DP  - 2014 Oct
TI  - Potential therapeutic utility of mesenchymal stem cells in inflammatory bowel 
      disease in mice.
PG  - 515-21
LID - S1567-5769(14)00307-5 [pii]
LID - 10.1016/j.intimp.2014.07.030 [doi]
AB  - Mesenchymal stem cells (MSCs) were found to provide an effective therapeutic role 
      in inflammatory diseases by modulating inflammatory responses and tissue 
      regeneration by their differentiation ability. The present work sought to 
      demonstrate the potential therapeutic use of MSCs in treating chronic 
      inflammatory bowel disease (IBD) in mice. A new model to induce chronic IBD based 
      on alternative administration periods of Dextran Sodium Sulfate (DSS) was 
      established. Mice were divided into 2 groups; one was treated with MSCs and the 
      other was treated with phosphate-buffered saline (PBS). Assessment of therapeutic 
      efficacy of MSCs was by measuring weight, stool scoring, histopathological 
      examination, and measuring the gene expression of inflammatory markers: 
      Interleukin-23 (IL-23), Tumor necrosis factor-alpha (TNF-alpha), Interferon-gamma (IFN-gamma), 
      and Intercellular adhesion molecule-1 (ICAM-1). The results showed that DSS 
      administration causes bloody and watery stool, weight loss, and altered 
      histopathologic picture. MSC treated mice showed a significant improvement in 
      stool condition, weight gain, and normal histopathologic picture compared to the 
      PBS treated mice. Moreover, gene expressions of inflammatory markers in the 
      intestines of the MSC treated mice were also significantly lower than those of 
      the PBS treated mice. In conclusion, the data here showed that MSCs have a clear 
      potential efficacy in the treatment for IBD, as their immune modulation effects 
      include inhibition in the expression of key inflammatory markers that each plays 
      an important role in the pathogenesis of IBD.
CI  - Copyright (c) 2014 Elsevier B.V. All rights reserved.
FAU - Abdel Salam, Ahmed G
AU  - Abdel Salam AG
AD  - Department of Biochemistry, Faculty of Pharmacy, Misr International University, 
      Cairo, Egypt. Electronic address: ahmed.gouda@miuegypt.edu.eg.
FAU - Ata, Hazem M
AU  - Ata HM
AD  - Department of Biochemistry, Faculty of Medicine, Cairo University, Egypt.
FAU - Salman, Tarek M
AU  - Salman TM
AD  - Department of Biochemistry, Faculty of Pharmacy, Al Azhar University, Cairo, 
      Egypt.
FAU - Rashed, Laila A
AU  - Rashed LA
AD  - Department of Biochemistry, Faculty of Medicine, Cairo University, Egypt.
FAU - Sabry, Dina
AU  - Sabry D
AD  - Department of Biochemistry, Faculty of Medicine, Cairo University, Egypt.
FAU - Schaalan, Mona F
AU  - Schaalan MF
AD  - Department of Biochemistry, Faculty of Pharmacy, Misr International University, 
      Cairo, Egypt; Department of Clinical Pharmacy and Pharmacy Practice, Faculty of 
      Pharmacy, Misr International University, Cairo, Egypt.
LA  - eng
PT  - Journal Article
DEP - 20140813
PL  - Netherlands
TA  - Int Immunopharmacol
JT  - International immunopharmacology
JID - 100965259
RN  - 0 (Cytokines)
RN  - 126547-89-5 (Intercellular Adhesion Molecule-1)
RN  - 9042-14-2 (Dextran Sulfate)
SB  - IM
MH  - Animals
MH  - Colon/pathology
MH  - Cytokines/genetics
MH  - Dextran Sulfate
MH  - Female
MH  - Gene Expression
MH  - Inflammatory Bowel Diseases/chemically induced/metabolism/pathology/*therapy
MH  - Intercellular Adhesion Molecule-1/genetics
MH  - Male
MH  - *Mesenchymal Stem Cell Transplantation
MH  - Mice
OTO - NOTNLM
OT  - Bone marrow derived mesenchymal stem cell transplantation
OT  - DSS induced colitis
OT  - Immunomodulation
EDAT- 2014/08/19 06:00
MHDA- 2015/06/10 06:00
CRDT- 2014/08/19 06:00
PHST- 2014/04/07 00:00 [received]
PHST- 2014/07/02 00:00 [revised]
PHST- 2014/07/27 00:00 [accepted]
PHST- 2014/08/19 06:00 [entrez]
PHST- 2014/08/19 06:00 [pubmed]
PHST- 2015/06/10 06:00 [medline]
AID - S1567-5769(14)00307-5 [pii]
AID - 10.1016/j.intimp.2014.07.030 [doi]
PST - ppublish
SO  - Int Immunopharmacol. 2014 Oct;22(2):515-21. doi: 10.1016/j.intimp.2014.07.030. 
      Epub 2014 Aug 13.