PMID- 25134387
OWN - NLM
STAT- MEDLINE
DCOM- 20140915
LR  - 20211203
IS  - 1433-6510 (Print)
IS  - 1433-6510 (Linking)
VI  - 60
IP  - 7
DP  - 2014
TI  - Reference interval for osteocalcin in Chinese Han ethnic males from the 
      Fangchenggang Area Male Health and Examination Survey.
PG  - 1177-85
AB  - BACKGROUND: The aim of this study was to set a reference interval (RI) for 
      osteocalcin (OC) in a healthy Han male population from the Fangchenggang Area 
      Male Health and Examination Survey (FAMHES) project and study the effects of age, 
      BMI, smoking, and alcohol consumption. METHODS: We used data from 2018 Han ethnic 
      males who participated in FAMHES project from September 2009 to December 2009. 
      Serum OC values were measured by electrochemiluminescence immunoassay on COBAS 
      6000 system E601 (Elecsys module) immunoassay analyzers. RESULTS: OC data does 
      not have a normal distribution or Gaussian pattern (Z = 3.791, p < 0.001). After 
      log-transformation, data took on a normal, Gaussian distribution (Z = 0.968, p = 
      0.306). The RI of serum OC was 12.49 - 43.94 ng/mL. No difference in OC 
      concentration was noted either between non-smoker or smoker groups (p = 0.629) or 
      non-drinker and drinker groups (p = 0.748). OC levels varied with age (r = 
      -0.371, p < 0.001) and BMI (r = -0.331, p < 0.001), and the age-dependent and 
      BMI-dependent RIs were calculated. CONCLUSIONS: The RIs for serum OC exhibit 
      slight differences compared to previously reported reference ranges. 
      Age-dependent and BMI-dependent RIs for serum OC should be implemented in 
      clinical laboratories.
FAU - Qin, Xue
AU  - Qin X
FAU - Wu, Huiling
AU  - Wu H
FAU - Mo, Zengnan
AU  - Mo Z
FAU - Chen, Zhiping
AU  - Chen Z
FAU - Luo, Shixing
AU  - Luo S
FAU - Gao, Yong
AU  - Gao Y
FAU - Tan, Aihua
AU  - Tan A
FAU - Yang, Xiaobo
AU  - Yang X
FAU - Zhang, Haiying
AU  - Zhang H
FAU - Peng, Tao
AU  - Peng T
FAU - Hu, Yanling
AU  - Hu Y
FAU - Huang, Shan
AU  - Huang S
FAU - Li, Haiwei
AU  - Li H
FAU - Deng, Yan
AU  - Deng Y
FAU - Peng, Qiliu
AU  - Peng Q
FAU - Lu, Qinghua
AU  - Lu Q
FAU - Li, Shan
AU  - Li S
FAU - Zhao, Jinmin
AU  - Zhao J
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - Germany
TA  - Clin Lab
JT  - Clinical laboratory
JID - 9705611
RN  - 104982-03-8 (Osteocalcin)
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - Aged
MH  - Aged, 80 and over
MH  - China
MH  - *Ethnicity
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Osteocalcin/blood/*standards
MH  - Physical Examination
MH  - Reference Values
MH  - Young Adult
EDAT- 2014/08/20 06:00
MHDA- 2014/09/16 06:00
CRDT- 2014/08/20 06:00
PHST- 2014/08/20 06:00 [entrez]
PHST- 2014/08/20 06:00 [pubmed]
PHST- 2014/09/16 06:00 [medline]
AID - 10.7754/clin.lab.2013.130331 [doi]
PST - ppublish
SO  - Clin Lab. 2014;60(7):1177-85. doi: 10.7754/clin.lab.2013.130331.