PMID- 25135618
OWN - NLM
STAT- MEDLINE
DCOM- 20150724
LR  - 20211021
IS  - 1432-198X (Electronic)
IS  - 0931-041X (Linking)
VI  - 30
IP  - 1
DP  - 2015 Jan
TI  - Indications, technique, and outcome of therapeutic apheresis in European 
      pediatric nephrology units.
PG  - 103-11
LID - 10.1007/s00467-014-2907-3 [doi]
AB  - BACKGROUND: Few observations on apheresis in pediatric nephrology units have been 
      published. METHODS: This retrospective study involved children </=18 years 
      undergoing plasma exchange (PE), immunoadsorption (IA), or double filtration 
      plasmapheresis (DFPP) in 12 European pediatric nephrology units during 2012. 
      RESULTS: Sixty-seven children underwent PE, ten IA, and three DFPP, for a total 
      of 738 PE and 349 IA/DFPP sessions; 67.2 % of PE and 69.2 % of IA/DFPP patients 
      were treated for renal diseases, in particular focal segmental glomerulosclerosis 
      (FSGS), hemolytic-uremic syndrome (HUS), and human leukocyte antigen (HLA) 
      desensitization prior to renal transplantation; 20.9 % of PE and 23.1 % of 
      IA/DFPP patients had neurological diseases. Membrane filtration was the most 
      common technique, albumin the most frequently used substitution fluid, and 
      heparin the preferred anticoagulant. PE achieved full disease remission in 25 
      patients (37.3 %), partial remission in 22 (32.8 %), and had no effect in 20 
      (29.9 %). The response to IA/DFPP was complete in seven patients (53.8 %), 
      partial in five (38.5 %), and absent in one (7.7 %). Minor adverse events 
      occurred during 6.9 % of PE and 9.7 % of IA/DFPP sessions. CONCLUSIONS: PE, IA, 
      and DFPP are safe apheresis methods in children. Efficacy is high in pediatric 
      patients with recurrent focal segmental glomerulosclerosis (FSGS), atypical 
      hemolytic uremic syndrome (HUS), human leukocyte antigen (HLA) sensitization, and 
      neurological autoimmune diseases.
FAU - Paglialonga, Fabio
AU  - Paglialonga F
AD  - Pediatric Nephrology and Dialysis Unit, Fondazione IRCCS Ca' Granda Ospedale 
      Maggiore Policlinico, Via Commenda, 9, 20122, Milan, Italy, 
      fabiopaglialonga@alice.it.
FAU - Schmitt, Claus Peter
AU  - Schmitt CP
FAU - Shroff, Rukshana
AU  - Shroff R
FAU - Vondrak, Karel
AU  - Vondrak K
FAU - Aufricht, Christoph
AU  - Aufricht C
FAU - Watson, Alan Rees
AU  - Watson AR
FAU - Ariceta, Gema
AU  - Ariceta G
FAU - Fischbach, Michael
AU  - Fischbach M
FAU - Klaus, Gunter
AU  - Klaus G
FAU - Holtta, Tuula
AU  - Holtta T
FAU - Bakkaloglu, Sevcan A
AU  - Bakkaloglu SA
FAU - Zurowska, Alexandra
AU  - Zurowska A
FAU - Jankauskiene, Augustina
AU  - Jankauskiene A
FAU - Vande Walle, Johan
AU  - Vande Walle J
FAU - Schaefer, Betti
AU  - Schaefer B
FAU - Wright, Elizabeth
AU  - Wright E
FAU - Connell, Roy
AU  - Connell R
FAU - Edefonti, Alberto
AU  - Edefonti A
LA  - eng
PT  - Journal Article
DEP - 20140820
PL  - Germany
TA  - Pediatr Nephrol
JT  - Pediatric nephrology (Berlin, Germany)
JID - 8708728
SB  - IM
MH  - Adolescent
MH  - Blood Component Removal/*methods/*statistics & numerical data
MH  - Child
MH  - Child, Preschool
MH  - Europe
MH  - Female
MH  - Humans
MH  - Infant
MH  - Kidney Diseases/*therapy
MH  - Male
MH  - Nephrology/methods
MH  - Pediatrics/methods
MH  - Retrospective Studies
EDAT- 2014/08/20 06:00
MHDA- 2015/07/25 06:00
CRDT- 2014/08/20 06:00
PHST- 2014/04/26 00:00 [received]
PHST- 2014/07/08 00:00 [accepted]
PHST- 2014/06/09 00:00 [revised]
PHST- 2014/08/20 06:00 [entrez]
PHST- 2014/08/20 06:00 [pubmed]
PHST- 2015/07/25 06:00 [medline]
AID - 10.1007/s00467-014-2907-3 [doi]
PST - ppublish
SO  - Pediatr Nephrol. 2015 Jan;30(1):103-11. doi: 10.1007/s00467-014-2907-3. Epub 2014 
      Aug 20.