PMID- 25136294
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20140819
LR  - 20220331
IS  - 1662-5102 (Print)
IS  - 1662-5102 (Electronic)
IS  - 1662-5102 (Linking)
VI  - 8
DP  - 2014
TI  - Astrocytic modulation of blood brain barrier: perspectives on Parkinson's 
      disease.
PG  - 211
LID - 10.3389/fncel.2014.00211 [doi]
LID - 211
AB  - The blood-brain barrier (BBB) is a tightly regulated interface in the Central 
      Nervous System (CNS) that regulates the exchange of molecules in and out from the 
      brain thus maintaining the CNS homeostasis. It is mainly composed of endothelial 
      cells (ECs), pericytes and astrocytes that create a neurovascular unit (NVU) with 
      the adjacent neurons. Astrocytes are essential for the formation and maintenance 
      of the BBB by providing secreted factors that lead to the adequate association 
      between the cells of the BBB and the formation of strong tight junctions. Under 
      neurological disorders, such as chronic cerebral ischemia, brain trauma, 
      Epilepsy, Alzheimer and Parkinson's Diseases, a disruption of the BBB takes 
      place, involving a lost in the permeability of the barrier and phenotypical 
      changes in both the ECs and astrocytes. In this aspect, it has been established 
      that the process of reactive gliosis is a common feature of astrocytes during BBB 
      disruption, which has a detrimental effect on the barrier function and a 
      subsequent damage in neuronal survival. In this review we discuss the 
      implications of astrocyte functions in the protection of the BBB, and in the 
      development of Parkinson's disease (PD) and related disorders. Additionally, we 
      highlight the current and future strategies in astrocyte protection aimed at the 
      development of restorative therapies for the BBB in pathological conditions.
FAU - Cabezas, Ricardo
AU  - Cabezas R
AD  - Departamento de Nutricion y Bioquimica, Facultad de Ciencias, Pontificia 
      Universidad Javeriana Bogota, D.C., Colombia.
FAU - Avila, Marcos
AU  - Avila M
AD  - Departamento de Nutricion y Bioquimica, Facultad de Ciencias, Pontificia 
      Universidad Javeriana Bogota, D.C., Colombia.
FAU - Gonzalez, Janneth
AU  - Gonzalez J
AD  - Departamento de Nutricion y Bioquimica, Facultad de Ciencias, Pontificia 
      Universidad Javeriana Bogota, D.C., Colombia.
FAU - El-Bacha, Ramon Santos
AU  - El-Bacha RS
AD  - Departamento de Biofuncao, Universidade Federal da Bahia Salvador, Brazil.
FAU - Baez, Eliana
AU  - Baez E
AD  - Departamento de Nutricion y Bioquimica, Facultad de Ciencias, Pontificia 
      Universidad Javeriana Bogota, D.C., Colombia.
FAU - Garcia-Segura, Luis Miguel
AU  - Garcia-Segura LM
AD  - Instituto Cajal, CSIC Madrid, Spain.
FAU - Jurado Coronel, Juan Camilo
AU  - Jurado Coronel JC
AD  - Departamento de Nutricion y Bioquimica, Facultad de Ciencias, Pontificia 
      Universidad Javeriana Bogota, D.C., Colombia.
FAU - Capani, Francisco
AU  - Capani F
AD  - Laboratorio de Citoarquitectura y Plasticidad Neuronal, Facultad de Medicina, 
      Instituto de Investigaciones cardiologicas Prof. Dr. Alberto C. Taquini (ININCA), 
      UBA-CONICET, Buenos Aires Argentina.
FAU - Cardona-Gomez, Gloria Patricia
AU  - Cardona-Gomez GP
AD  - Cellular and Molecular Neurobiology Area, Group of Neuroscience of Antioquia, 
      Faculty of Medicine, SIU, University of Antioquia UdeA Medellin, Colombia.
FAU - Barreto, George E
AU  - Barreto GE
AD  - Departamento de Nutricion y Bioquimica, Facultad de Ciencias, Pontificia 
      Universidad Javeriana Bogota, D.C., Colombia.
LA  - eng
PT  - Journal Article
PT  - Review
DEP - 20140804
PL  - Switzerland
TA  - Front Cell Neurosci
JT  - Frontiers in cellular neuroscience
JID - 101477935
PMC - PMC4120694
OTO - NOTNLM
OT  - BBB
OT  - Parkinson disease
OT  - astrocytes
OT  - endothelial cells
OT  - reactive astrogliosis
EDAT- 2014/08/20 06:00
MHDA- 2014/08/20 06:01
PMCR- 2014/01/01
CRDT- 2014/08/20 06:00
PHST- 2014/05/29 00:00 [received]
PHST- 2014/07/14 00:00 [accepted]
PHST- 2014/08/20 06:00 [entrez]
PHST- 2014/08/20 06:00 [pubmed]
PHST- 2014/08/20 06:01 [medline]
PHST- 2014/01/01 00:00 [pmc-release]
AID - 10.3389/fncel.2014.00211 [doi]
PST - epublish
SO  - Front Cell Neurosci. 2014 Aug 4;8:211. doi: 10.3389/fncel.2014.00211. eCollection 
      2014.