PMID- 25136516
OWN - NLM
STAT- MEDLINE
DCOM- 20150330
LR  - 20211021
IS  - 2235-2988 (Electronic)
IS  - 2235-2988 (Linking)
VI  - 4
DP  - 2014
TI  - Induction of endoplasmic reticulum stress and unfolded protein response 
      constitutes a pathogenic strategy of group A streptococcus.
PG  - 105
LID - 10.3389/fcimb.2014.00105 [doi]
LID - 105
AB  - The connection between bacterial pathogens and unfolded protein response (UPR) is 
      poorly explored. In this review we highlight the evidence showing that group A 
      streptococcus (GAS) induces endoplasmic reticulum (ER) stress and UPR through 
      which it captures the amino acid asparagine (ASN) from the host. GAS acts 
      extracellularly and during adherence to host cells it delivers the hemolysin 
      toxins; streptolysin O (SLO) and streptolysin S (SLS). By poorly understood 
      pathways, these toxins trigger UPR leading to the induction of the 
      transcriptional regulator ATF4 and consequently to the upregulation of asparagine 
      synthetase (ASNS) transcription leading to production and release of ASN. GAS 
      senses ASN and alters gene expression profile accordingly, and increases the rate 
      of multiplication. We suggest that induction of UPR by GAS and by other bacterial 
      pathogens represent means through which bacterial pathogens gain nutrients from 
      the host, obviating the need to become internalized or inflict irreversible cell 
      damage.
FAU - Baruch, Moshe
AU  - Baruch M
AD  - Department of Microbiology and Molecular Genetics, Faculty of Medicine, The 
      Hebrew University of Jerusalem (HUJI) Jerusalem, Israel.
FAU - Hertzog, Baruch B
AU  - Hertzog BB
AD  - Department of Microbiology and Molecular Genetics, Faculty of Medicine, The 
      Hebrew University of Jerusalem (HUJI) Jerusalem, Israel.
FAU - Ravins, Miriam
AU  - Ravins M
AD  - Department of Microbiology and Molecular Genetics, Faculty of Medicine, The 
      Hebrew University of Jerusalem (HUJI) Jerusalem, Israel.
FAU - Anand, Aparna
AU  - Anand A
AD  - Department of Microbiology and Molecular Genetics, Faculty of Medicine, The 
      Hebrew University of Jerusalem (HUJI) Jerusalem, Israel.
FAU - Cheng, Catherine Youting
AU  - Cheng CY
AD  - Department of Microbiology, Center for Research Excellence and Technological 
      Enterprise (CREATE), National University of Singapore (NUS) and NUS-HUJI 
      Singapore.
FAU - Biswas, Debabrata
AU  - Biswas D
AD  - Department of Microbiology and Molecular Genetics, Faculty of Medicine, The 
      Hebrew University of Jerusalem (HUJI) Jerusalem, Israel ; Department of 
      Microbiology, Center for Research Excellence and Technological Enterprise 
      (CREATE), National University of Singapore (NUS) and NUS-HUJI Singapore.
FAU - Tirosh, Boaz
AU  - Tirosh B
AD  - The School of Pharmacy, Institute for Drug Research, The Hebrew University of 
      Jerusalem Jerusalem, Israel.
FAU - Hanski, Emanuel
AU  - Hanski E
AD  - Department of Microbiology and Molecular Genetics, Faculty of Medicine, The 
      Hebrew University of Jerusalem (HUJI) Jerusalem, Israel ; Department of 
      Microbiology, Center for Research Excellence and Technological Enterprise 
      (CREATE), National University of Singapore (NUS) and NUS-HUJI Singapore.
LA  - eng
PT  - Journal Article
PT  - Review
DEP - 20140804
PL  - Switzerland
TA  - Front Cell Infect Microbiol
JT  - Frontiers in cellular and infection microbiology
JID - 101585359
RN  - 0 (Bacterial Proteins)
RN  - 0 (Streptolysins)
RN  - 0 (streptolysin O)
RN  - 0 (streptolysin S)
RN  - 7006-34-0 (Asparagine)
SB  - IM
MH  - Animals
MH  - Asparagine/metabolism
MH  - Bacterial Proteins/metabolism
MH  - *Endoplasmic Reticulum Stress
MH  - Host-Pathogen Interactions
MH  - Humans
MH  - Streptococcal Infections/genetics/*metabolism/microbiology
MH  - Streptococcus pyogenes/*physiology
MH  - Streptolysins/metabolism
MH  - *Unfolded Protein Response
PMC - PMC4120759
OTO - NOTNLM
OT  - UPR
OT  - asparaginase
OT  - asparagine
OT  - group A streptococcus
OT  - metabolism
OT  - virulence
EDAT- 2014/08/20 06:00
MHDA- 2015/03/31 06:00
PMCR- 2014/01/01
CRDT- 2014/08/20 06:00
PHST- 2014/05/28 00:00 [received]
PHST- 2014/07/14 00:00 [accepted]
PHST- 2014/08/20 06:00 [entrez]
PHST- 2014/08/20 06:00 [pubmed]
PHST- 2015/03/31 06:00 [medline]
PHST- 2014/01/01 00:00 [pmc-release]
AID - 10.3389/fcimb.2014.00105 [doi]
PST - epublish
SO  - Front Cell Infect Microbiol. 2014 Aug 4;4:105. doi: 10.3389/fcimb.2014.00105. 
      eCollection 2014.