PMID- 25136573
OWN - NLM
STAT- MEDLINE
DCOM- 20150511
LR  - 20221207
IS  - 2314-6141 (Electronic)
IS  - 2314-6133 (Print)
VI  - 2014
DP  - 2014
TI  - Designing peptide-based HIV vaccine for Chinese.
PG  - 272950
LID - 10.1155/2014/272950 [doi]
LID - 272950
AB  - CD4+ T cells are central to the induction and maintenance of CD8+ T cell and 
      antibody-producing B cell responses, and the latter are essential for the 
      protection against disease in subjects with HIV infection. How to elicit 
      HIV-specific CD4+ T cell responses in a given population using vaccines is one of 
      the major areas of current HIV vaccine research. To design vaccine that targets 
      specifically Chinese, we assembled a database that is comprised of sequences from 
      821 Chinese HIV isolates and 46 human leukocyte antigen (HLA) DR alleles 
      identified in Chinese population. We then predicted 20 potential HIV epitopes 
      using bioinformatics approaches. The combination of these 20 epitopes has a 
      theoretical coverage of 98.1% of the population for both the prevalent HIV 
      genotypes and also Chinese HLA-DR types. We suggest that testing this vaccine 
      experimentally will facilitate the development of a CD4+ T cell vaccine 
      especially catered for Chinese.
FAU - Shu, Jiayi
AU  - Shu J
AUID- ORCID: 0000-0002-3705-3259
AD  - Viral Disease and Vaccine Translational Research Unit, Institut Pasteur of 
      Shanghai, Chinese Academy of Sciences, Room 507, Building B, Life Science 
      Research Building, 320 Yueyang Road, Shanghai 200031, China ; Vaccine Centre, 
      Institut Pasteur of Shanghai, Chinese Academy of Sciences, 320 Yueyang Road, 
      Shanghai 200031, China.
FAU - Fan, Xiaojuan
AU  - Fan X
AD  - Bioinformatics Platform, Institut Pasteur of Shanghai, Chinese Academy of 
      Sciences, Room 405, Building B, Life Science Research Building, 320 Yueyang Road, 
      Shanghai 200031, China.
FAU - Ping, Jie
AU  - Ping J
AUID- ORCID: 0000-0001-9907-5819
AD  - Bioinformatics Platform, Institut Pasteur of Shanghai, Chinese Academy of 
      Sciences, Room 405, Building B, Life Science Research Building, 320 Yueyang Road, 
      Shanghai 200031, China.
FAU - Jin, Xia
AU  - Jin X
AUID- ORCID: 0000-0002-4185-1966
AD  - Viral Disease and Vaccine Translational Research Unit, Institut Pasteur of 
      Shanghai, Chinese Academy of Sciences, Room 507, Building B, Life Science 
      Research Building, 320 Yueyang Road, Shanghai 200031, China ; Vaccine Centre, 
      Institut Pasteur of Shanghai, Chinese Academy of Sciences, 320 Yueyang Road, 
      Shanghai 200031, China.
FAU - Hao, Pei
AU  - Hao P
AUID- ORCID: 0000-0002-1498-7059
AD  - Bioinformatics Platform, Institut Pasteur of Shanghai, Chinese Academy of 
      Sciences, Room 405, Building B, Life Science Research Building, 320 Yueyang Road, 
      Shanghai 200031, China.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20140706
PL  - United States
TA  - Biomed Res Int
JT  - BioMed research international
JID - 101600173
RN  - 0 (AIDS Vaccines)
RN  - 0 (HLA-DR Antigens)
RN  - 0 (Peptides)
SB  - IM
MH  - *AIDS Vaccines/genetics/immunology
MH  - *Alleles
MH  - *Asian People
MH  - China
MH  - Drug Design
MH  - Female
MH  - *Gene Frequency/genetics/immunology
MH  - *HLA-DR Antigens/genetics/immunology
MH  - Humans
MH  - Male
MH  - *Peptides/genetics/immunology
PMC - PMC4106118
EDAT- 2014/08/20 06:00
MHDA- 2015/05/12 06:00
PMCR- 2014/07/06
CRDT- 2014/08/20 06:00
PHST- 2014/04/15 00:00 [received]
PHST- 2014/06/16 00:00 [accepted]
PHST- 2014/08/20 06:00 [entrez]
PHST- 2014/08/20 06:00 [pubmed]
PHST- 2015/05/12 06:00 [medline]
PHST- 2014/07/06 00:00 [pmc-release]
AID - 10.1155/2014/272950 [doi]
PST - ppublish
SO  - Biomed Res Int. 2014;2014:272950. doi: 10.1155/2014/272950. Epub 2014 Jul 6.