PMID- 25138265
OWN - NLM
STAT- MEDLINE
DCOM- 20150922
LR  - 20211021
IS  - 1433-2965 (Electronic)
IS  - 0937-941X (Linking)
VI  - 26
IP  - 1
DP  - 2015 Jan
TI  - Effects of vitamin D supplementation on neuroplasticity in older adults: a 
      double-blinded, placebo-controlled randomised trial.
PG  - 131-40
LID - 10.1007/s00198-014-2855-6 [doi]
AB  - Vitamin D can improve muscle function and reduce falls, but whether it can 
      strengthen neural connections within the brain and nervous system is not known. 
      This 10-week randomised controlled trial indicates that treatment with 2,000 
      IU/day vitamin D3 does not significantly alter neuroplasticity relative to 
      placebo in older adults. INTRODUCTION: The purpose of this study was to examine 
      the effects of vitamin D supplementation on neuroplasticity, serum brain-derived 
      neurotrophic factor (BDNF) and muscle strength and function in older adults. 
      METHODS: This was a 10-week double-blinded, placebo-controlled randomised trial 
      in which 26 older adults with 25-hydroxyvitamin D [25OHD] concentrations 25-60 
      nmol/L were randomised to 2,000 IU/day vitamin D3 or matched placebo. Single- and 
      paired-pulse transcranial magnetic stimulation applied over the motor cortex was 
      used to assess changes in motor-evoked potentials (MEPs) and short-interval 
      intracortical inhibition (SICI), as measures of corticospinal excitability and 
      inhibition respectively, by recording electromyography (EMG) responses to 
      stimulation from the wrist extensors. Changes in muscle strength, stair climbing 
      power, gait (timed-up-and-go), dynamic balance (four square step test), serum 
      25(OH)D and BDNF concentrations were also measured. RESULTS: After 10 weeks, mean 
      25(OH)D levels increased from 46 to 81 nmol/L in the vitamin D group with no 
      change in the placebo group. The vitamin D group experienced a significant 8-11% 
      increase in muscle strength and a reduction in cortical excitability (MEP 
      amplitude) and SICI relative to baseline (all P < 0.05), but these changes were 
      not significantly different from placebo. There was no effect of vitamin D on 
      muscle power, function or BDNF. CONCLUSIONS: Daily supplementation with 2,000 IU 
      vitamin D3 for 10 weeks had no significant effect on neuroplasticity compared to 
      placebo, but the finding that vitamin D treatment alone was associated with a 
      decrease in corticospinal excitability and intracortical inhibition warrants 
      further investigation as this suggests that it may improve the efficacy of neural 
      transmission within the corticospinal pathway.
FAU - Pirotta, S
AU  - Pirotta S
AD  - Centre for Physical Activity and Nutrition Research, School of Exercise and 
      Nutrition Sciences, Deakin University, 221 Burwood Highway, Burwood, VIC, 3125, 
      Australia.
FAU - Kidgell, D J
AU  - Kidgell DJ
FAU - Daly, R M
AU  - Daly RM
LA  - eng
PT  - Journal Article
PT  - Randomized Controlled Trial
DEP - 20140820
PL  - England
TA  - Osteoporos Int
JT  - Osteoporosis international : a journal established as result of cooperation 
      between the European Foundation for Osteoporosis and the National Osteoporosis 
      Foundation of the USA
JID - 9100105
RN  - 0 (Brain-Derived Neurotrophic Factor)
RN  - 1406-16-2 (Vitamin D)
RN  - 1C6V77QF41 (Cholecalciferol)
RN  - 7171WSG8A2 (BDNF protein, human)
RN  - A288AR3C9H (25-hydroxyvitamin D)
SB  - IM
MH  - Aged
MH  - Anthropometry/methods
MH  - Brain-Derived Neurotrophic Factor/blood
MH  - Cholecalciferol/*pharmacology
MH  - Diet
MH  - *Dietary Supplements
MH  - Double-Blind Method
MH  - Elder Nutritional Physiological Phenomena/physiology
MH  - Evoked Potentials, Motor/drug effects/physiology
MH  - Female
MH  - Humans
MH  - Male
MH  - Medication Adherence/statistics & numerical data
MH  - Middle Aged
MH  - Motor Activity/physiology
MH  - Muscle Strength/drug effects/physiology
MH  - Muscle, Skeletal/physiology
MH  - Neuronal Plasticity/*drug effects/physiology
MH  - Transcranial Magnetic Stimulation/methods
MH  - Vitamin D/analogs & derivatives/blood
EDAT- 2014/08/21 06:00
MHDA- 2015/09/24 06:00
CRDT- 2014/08/21 06:00
PHST- 2014/05/04 00:00 [received]
PHST- 2014/08/12 00:00 [accepted]
PHST- 2014/08/21 06:00 [entrez]
PHST- 2014/08/21 06:00 [pubmed]
PHST- 2015/09/24 06:00 [medline]
AID - 10.1007/s00198-014-2855-6 [doi]
PST - ppublish
SO  - Osteoporos Int. 2015 Jan;26(1):131-40. doi: 10.1007/s00198-014-2855-6. Epub 2014 
      Aug 20.