PMID- 25139533
OWN - NLM
STAT- MEDLINE
DCOM- 20150811
LR  - 20141216
IS  - 1098-1063 (Electronic)
IS  - 1050-9631 (Linking)
VI  - 25
IP  - 1
DP  - 2015 Jan
TI  - Increased oligodendrogenesis by humanin promotes axonal remyelination and 
      neurological recovery in hypoxic/ischemic brains.
PG  - 62-71
LID - 10.1002/hipo.22350 [doi]
AB  - Oligodendrocytes are the predominant cell type in white matter and are highly 
      vulnerable to ischemic injury. The role of oligodendrocyte dysfunction in 
      ischemic brain injury is unknown. In this study, we used a 24-amino acid peptide 
      S14G-Humanin (HNG) to examine oligodendrogenesis and neurological functional 
      recovery in a hypoxic/ischemic (H/I) neonatal model. Intraperitoneal HNG 
      pre-treatment decreased infarct volume following H/I injury. Delayed HNG 
      treatment 24 h after H/I injury did not reduce infarct volume but did decrease 
      neurological deficits and brain atrophy. Delayed HNG treatment did not attenuate 
      axonal demyelination at 48 h after H/I injury. However, at 14 d after H/I injury, 
      delayed HNG treatment increased axonal remyelination, the thickness of corpus 
      callosum at the midline, the number of Olig2(+) /BrdU(+) cells, and levels of 
      brain-derived neurotrophic factor (BDNF). Our results suggest that targeting 
      oligodendrogenesis via delayed HNG treatment may represent a promising approach 
      for the treatment of stroke.
CI  - (c) 2014 Wiley Periodicals, Inc.
FAU - Chen, Jing
AU  - Chen J
AD  - Jiangsu Key Laboratory of Translational Research and Therapy for 
      Neuro-Psycho-Diseases, the Second Affiliated Hospital of Soochow University, 
      Soochow University, Suzhou City, China; The Institute of Neuroscience, Soochow 
      University, Suzhou City, China.
FAU - Sun, Miao
AU  - Sun M
FAU - Zhang, Xia
AU  - Zhang X
FAU - Miao, Zhigang
AU  - Miao Z
FAU - Chua, Balvin H L
AU  - Chua BH
FAU - Hamdy, Ronald C
AU  - Hamdy RC
FAU - Zhang, Quan-Guang
AU  - Zhang QG
FAU - Liu, Chun-Feng
AU  - Liu CF
FAU - Xu, Xingshun
AU  - Xu X
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20140910
PL  - United States
TA  - Hippocampus
JT  - Hippocampus
JID - 9108167
RN  - 0 (Brain-Derived Neurotrophic Factor)
RN  - 0 (Intracellular Signaling Peptides and Proteins)
RN  - 0 (humanin)
SB  - IM
MH  - Animals
MH  - Animals, Newborn
MH  - Atrophy/pathology
MH  - Axons/drug effects/pathology
MH  - Brain-Derived Neurotrophic Factor/drug effects
MH  - Cerebral Infarction/drug therapy/pathology/physiopathology
MH  - Disease Models, Animal
MH  - Hypoxia-Ischemia, Brain/*drug therapy/pathology/physiopathology
MH  - Intracellular Signaling Peptides and Proteins/administration & 
      dosage/*pharmacology
MH  - Neurogenesis/*drug effects
MH  - Oligodendroglia/*drug effects
MH  - Random Allocation
MH  - Rats
MH  - Rats, Sprague-Dawley
MH  - Recovery of Function/*drug effects
OTO - NOTNLM
OT  - brain-derived neurotrophic factor
OT  - humanin
OT  - hypoxic/ischemic injury
OT  - oligodendrocyte
OT  - remyelination
EDAT- 2014/08/21 06:00
MHDA- 2015/08/12 06:00
CRDT- 2014/08/21 06:00
PHST- 2014/08/13 00:00 [accepted]
PHST- 2014/08/21 06:00 [entrez]
PHST- 2014/08/21 06:00 [pubmed]
PHST- 2015/08/12 06:00 [medline]
AID - 10.1002/hipo.22350 [doi]
PST - ppublish
SO  - Hippocampus. 2015 Jan;25(1):62-71. doi: 10.1002/hipo.22350. Epub 2014 Sep 10.