PMID- 25140585
OWN - NLM
STAT- MEDLINE
DCOM- 20150914
LR  - 20150106
IS  - 1814-1412 (Electronic)
IS  - 1562-2975 (Linking)
VI  - 16
IP  - 1
DP  - 2015 Jan
TI  - Add-on deep transcranial magnetic stimulation (dTMS) in patients with dysthymic 
      disorder comorbid with alcohol use disorder: a comparison with standard 
      treatment.
PG  - 66-73
LID - 10.3109/15622975.2014.925583 [doi]
AB  - OBJECTIVES: Dorsolateral prefrontal cortex (DLPFC) is dysfunctional in mood and 
      substance use disorders. We predicted higher efficacy for add-on bilateral 
      prefrontal high-frequency deep transcranial magnetic stimulation (dTMS), compared 
      with standard drug treatment (SDT) in patients with dysthymic disorder 
      (DD)/alcohol use disorder (AUD) comorbidity. METHODS: We carried-out a 6-month 
      open-label study involving 20 abstinent patients with DSM-IV-TR AUD comorbid with 
      previously developed DD. Ten patients received SDT for AUD with add-on bilateral 
      dTMS (dTMS-AO) over the DLPFC, while another 10 received SDT alone. We rated 
      alcohol craving with the Obsessive Compulsive Drinking Scale (OCDS), depression 
      with the Hamilton Depression Rating Scale (HDRS), clinical status with the 
      Clinical Global Impressions scale (CGI), and global functioning with the Global 
      Assessment of Functioning (GAF). RESULTS: At the end of the 20-session dTMS 
      period (or an equivalent period in the SDT group), craving scores and depressive 
      symptoms in the dTMS-AO group dropped significantly more than in the SDT group (P 
      < 0.001 and P < 0.02, respectively). CONCLUSIONS: High frequency bilateral DLPFC 
      dTMS with left preference was well tolerated and found to be effective as add-on 
      in AUD. The potential of dTMS for reducing craving in substance use disorder 
      patients deserves to be further investigated.
FAU - Girardi, Paolo
AU  - Girardi P
AD  - NESMOS Department (Neurosciences, Mental Health, and Sensory Organs), Sapienza 
      University of Rome, School of Medicine and Psychology, Sant'Andrea Hospital , 
      Rome , Italy.
FAU - Rapinesi, Chiara
AU  - Rapinesi C
FAU - Chiarotti, Flavia
AU  - Chiarotti F
FAU - Kotzalidis, Georgios D
AU  - Kotzalidis GD
FAU - Piacentino, Daria
AU  - Piacentino D
FAU - Serata, Daniele
AU  - Serata D
FAU - Del Casale, Antonio
AU  - Del Casale A
FAU - Scatena, Paola
AU  - Scatena P
FAU - Mascioli, Flavia
AU  - Mascioli F
FAU - Raccah, Ruggero N
AU  - Raccah RN
FAU - Brugnoli, Roberto
AU  - Brugnoli R
FAU - Digiacomantonio, Vittorio
AU  - Digiacomantonio V
FAU - Ferri, Vittoria Rachele
AU  - Ferri VR
FAU - Ferracuti, Stefano
AU  - Ferracuti S
FAU - Zangen, Abraham
AU  - Zangen A
FAU - Angeletti, Gloria
AU  - Angeletti G
LA  - eng
PT  - Comparative Study
PT  - Journal Article
DEP - 20140820
PL  - England
TA  - World J Biol Psychiatry
JT  - The world journal of biological psychiatry : the official journal of the World 
      Federation of Societies of Biological Psychiatry
JID - 101120023
SB  - IM
MH  - Adult
MH  - Affect
MH  - Aged
MH  - Alcohol-Related Disorders/drug therapy/*therapy
MH  - Comorbidity
MH  - Craving
MH  - Depressive Disorder, Major/drug therapy/*therapy
MH  - Dysthymic Disorder/drug therapy/*therapy
MH  - Female
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Prefrontal Cortex/physiopathology
MH  - Psychiatric Status Rating Scales
MH  - Transcranial Magnetic Stimulation/*methods
OTO - NOTNLM
OT  - alcohol
OT  - deep Transcranial magnetic stimulation (dTMS)
OT  - depression
OT  - dorsolateral pre-frontal cortex (DLPFC)
OT  - dysthymia
EDAT- 2014/08/21 06:00
MHDA- 2015/09/15 06:00
CRDT- 2014/08/21 06:00
PHST- 2014/08/21 06:00 [entrez]
PHST- 2014/08/21 06:00 [pubmed]
PHST- 2015/09/15 06:00 [medline]
AID - 10.3109/15622975.2014.925583 [doi]
PST - ppublish
SO  - World J Biol Psychiatry. 2015 Jan;16(1):66-73. doi: 10.3109/15622975.2014.925583. 
      Epub 2014 Aug 20.