PMID- 25141872
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20140822
LR  - 20140821
IS  - 2040-1744 (Print)
IS  - 2040-1744 (Linking)
VI  - 1
IP  - 4
DP  - 2010 Aug
TI  - Maternal high fat diet during critical windows of development alters adrenal 
      cortical and medullary enzyme expression in adult male rat offspring.
PG  - 245-54
LID - 10.1017/S2040174410000346 [doi]
AB  - We previously reported that a maternal high fat (HF) diet resulted in adult 
      offspring with increased adiposity and hyperleptinemia. As leptin has an 
      inhibitory effect on adrenal steroidogenesis and a stimulatory effect on 
      epinephrine synthesis, we hypothesized that key adrenal steroidogenic and 
      catecholaminergic enzymes would be altered in these offspring. Wistar rats were 
      randomized into three groups at weaning: (1) control dams fed a standard control 
      chow diet from weaning and throughout pregnancy and lactation (CON), (2) dams fed 
      a HF diet from weaning and throughout pregnancy and lactation (MHF) and (3) dams 
      fed standard control chow diet throughout life until conception, then fed a HF 
      diet in pregnancy and lactation (PLHF). Dams were mated at day 100 (P100). After 
      birth at P22 (weaning), male offspring were fed a standard control chow (con) or 
      high fat (hf) diet. At P160, plasma samples and adrenal tissues were collected. 
      Postweaning hf diet significantly elevated plasma corticosterone concentrations 
      in PLHF-hf offspring compared to PLHF-con. MHF nutrition increased adrenal 
      adrenocorticotrophic hormone receptor (ACTH-R) mRNA levels compared to CON-con. 
      3beta-hydroxysteroid dehydrogenase (3betaHSD) mRNA levels were decreased in MHF 
      compared to PLHF offspring. Phenylethanolamine N-methyltransferase (PNMT) mRNA 
      levels were increased in MHF-hf offspring compared to MHF-con. Plasma 
      homocysteine (HCY) concentrations were significantly elevated in CON-hf and 
      MHF-hf offspring compared to chow-fed offspring, associated with elevated intakes 
      of methionine and reduced intakes of pyridoxine. Immunoreactive leptin receptor 
      (ObRb) and PNMT were colocalized in medullary chromaffin cells. This study 
      suggests that a postweaning HF diet in offspring induced changes in adrenal gene 
      expression levels that are dependent upon the level of maternal nutrition.
FAU - Connor, K L
AU  - Connor KL
AD  - Liggins Institute and the National Research Centre for Growth and Development, 
      University of Auckland, Auckland, New Zealand.
FAU - Vickers, M H
AU  - Vickers MH
AD  - Liggins Institute and the National Research Centre for Growth and Development, 
      University of Auckland, Auckland, New Zealand.
FAU - Cupido, C
AU  - Cupido C
AD  - Liggins Institute and the National Research Centre for Growth and Development, 
      University of Auckland, Auckland, New Zealand.
FAU - Sirimanne, E
AU  - Sirimanne E
AD  - Liggins Institute and the National Research Centre for Growth and Development, 
      University of Auckland, Auckland, New Zealand.
FAU - Sloboda, D M
AU  - Sloboda DM
AD  - Liggins Institute and the National Research Centre for Growth and Development, 
      University of Auckland, Auckland, New Zealand.
LA  - eng
PT  - Journal Article
PL  - England
TA  - J Dev Orig Health Dis
JT  - Journal of developmental origins of health and disease
JID - 101517692
EDAT- 2010/08/01 00:00
MHDA- 2010/08/01 00:01
CRDT- 2014/08/22 06:00
PHST- 2014/08/22 06:00 [entrez]
PHST- 2010/08/01 00:00 [pubmed]
PHST- 2010/08/01 00:01 [medline]
AID - S2040174410000346 [pii]
AID - 10.1017/S2040174410000346 [doi]
PST - ppublish
SO  - J Dev Orig Health Dis. 2010 Aug;1(4):245-54. doi: 10.1017/S2040174410000346.