PMID- 25143124
OWN - NLM
STAT- MEDLINE
DCOM- 20150529
LR  - 20151119
IS  - 1440-1827 (Electronic)
IS  - 1320-5463 (Linking)
VI  - 64
IP  - 8
DP  - 2014 Aug
TI  - Expression of developing neural transcription factors in lung carcinoid tumors.
PG  - 365-74
LID - 10.1111/pin.12183 [doi]
AB  - In lung tumors, the association between carcinoids and high-grade neuroendocrine 
      tumors (HGNETs) is controversial. To understand the phenotypic 
      similarities/differences between lung carcinoids and HGNETs, we comparatively 
      investigated the expression of three kinds of developing neural transcription 
      factors (DNTFs: BRN2, TTF1 and ASCL1) and multiple endocrine neoplasia type 1 
      (MEN1) as well as RB1 and P53 using 18 carcinoids and 16 HGNETs. The DNTFs were 
      expressed in 10 of the 18 carcinoids and in all the HGNETs, while normal 
      neuroendocrine cells, which are considered the major cell origin of lung 
      carcinoids and small cell carcinomas, did not express DNTFs. Both the DNTF(-) and 
      DNTF(+) carcinoids contained typical and atypical carcinoids. All the DNTF(-) 
      carcinoids examined were formed in the bronchial wall. All the MEN1(-) carcinoids 
      examined were classified into the DNTF(-) carcinoids, while all the HGNETs 
      expressed MEN1. This finding suggests that DNTF(-) MEN1(-) carcinoids are 
      unlikely to be precursors of HGNETs. Although the status of RB1 and P53 between 
      carcinoids and HGNETs were apparently different, the DNTF(+) carcinoids of two 
      male patients and one female patient revealed morphologies resembling HGNET cells 
      and relatively high Ki67 indices. Further investigation of DNTF expression in 
      carcinoids might provide important clues to understand the association between 
      carcinoids and HGNETs.
CI  - (c) 2014 Japanese Society of Pathology and Wiley Publishing Asia Pty Ltd.
FAU - Endo, Tetsuya
AU  - Endo T
AD  - Department of Pathology, Kyorin University School of Medicine, Mitaka, Japan; 
      Department of General Thoracic Surgery, Jichi Medical University, Shimotsuke, 
      Japan.
FAU - Yazawa, Takuya
AU  - Yazawa T
FAU - Shishido-Hara, Yukiko
AU  - Shishido-Hara Y
FAU - Fujiwara, Masachika
AU  - Fujiwara M
FAU - Shimoyamada, Hiroaki
AU  - Shimoyamada H
FAU - Ishii, Jun
AU  - Ishii J
FAU - Sato, Hanako
AU  - Sato H
FAU - Tachibana, Keisei
AU  - Tachibana K
FAU - Takei, Hidefumi
AU  - Takei H
FAU - Kondo, Haruhiko
AU  - Kondo H
FAU - Goya, Tomoyuki
AU  - Goya T
FAU - Endo, Shunsuke
AU  - Endo S
FAU - Kamma, Hiroshi
AU  - Kamma H
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - Australia
TA  - Pathol Int
JT  - Pathology international
JID - 9431380
RN  - 0 (Biomarkers, Tumor)
RN  - 0 (Transcription Factors)
SB  - IM
MH  - Adult
MH  - Aged
MH  - Aged, 80 and over
MH  - Biomarkers, Tumor/*genetics
MH  - Carcinoid Tumor/*genetics/pathology
MH  - Female
MH  - Gene Expression Regulation, Neoplastic
MH  - Humans
MH  - Lung Neoplasms/*genetics/pathology
MH  - Male
MH  - Middle Aged
MH  - Neoplasm Grading/methods
MH  - Transcription Factors/*genetics
OTO - NOTNLM
OT  - ASCL1
OT  - BRN2
OT  - MEN1
OT  - TTF1
OT  - carcinoid tumor
OT  - high-grade neuroendocrine tumor
OT  - large cell neuroendocrine carcinoma
OT  - lung
OT  - small cell carcinoma
EDAT- 2014/08/22 06:00
MHDA- 2015/05/30 06:00
CRDT- 2014/08/22 06:00
PHST- 2013/10/30 00:00 [received]
PHST- 2014/06/22 00:00 [accepted]
PHST- 2014/08/22 06:00 [entrez]
PHST- 2014/08/22 06:00 [pubmed]
PHST- 2015/05/30 06:00 [medline]
AID - 10.1111/pin.12183 [doi]
PST - ppublish
SO  - Pathol Int. 2014 Aug;64(8):365-74. doi: 10.1111/pin.12183.