PMID- 25143907
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20140821
LR  - 20211021
IS  - 2230-8210 (Print)
IS  - 2230-9500 (Electronic)
IS  - 2230-9500 (Linking)
VI  - 18
IP  - 4
DP  - 2014 Jul
TI  - Serum monocyte chemoattractant protein-1 is a biomarker in patients with diabetes 
      and periodontitis.
PG  - 505-10
LID - 10.4103/2230-8210.137498 [doi]
AB  - INTRODUCTION: The role of serum Monocyte Chemoattractant Protein-1 (MCP-1) as a 
      biomarker of periodontitis is well documented; however, its role in diabetic 
      patients with periodontitis is unknown. AIM: This study was conducted to 
      determine the presence and concentration of serum MCP-1 in diabetic patients with 
      and without periodontitis and correlate it glycemic status with periodontitis. 
      MATERIALS AND METHODS: Adult diabetic patients were enrolled and grouped into 
      group I, II, and III based on their glycemic status and serum MCP-1 estimated by 
      ELISA. Linear regression and correlation tests were performed using R statistical 
      software, Medcalc software to observe correlation between the serum MCP-1 and 
      glycated hemoglobin level among different groups. RESULTS: Serum samples obtained 
      from 37 patients tested positive for MCP-1. Mean serum MCP-1 concentration was 
      highest (482.3 pg/ml) in group III, lowest (149.3 pg/ml) in group I, and 
      intermediate 398.8 pg/ml in group II. Correlation and regression analysis was 
      done between HbA1c and serum MCP-1. A significant positive correlation (P < 
      0.001) was observed. Serum MCP-1 increased by 37.278 pg/ml for every 1% rise in 
      HbA1c, and the levels were raised in group II and group III than in group I 
      irrespective of their glycemic status. With an HbA1c range of 6.5-6.9% (group 
      II), the serum MCP-1 values cluster around 380-410 pg/ml. Elevated levels of 
      serum MCP-1 (>500 pg/ml) in three subjects corresponded to HbA1c values more than 
      12.2% (group III). CONCLUSION: To our knowledge, this is the first study to 
      document serum MCP-1 levels in diabetic patients with periodontitis. Glycemic 
      status influences serum MCP-1, and lack of glycemic control contributes to 
      increased serum MCP-1 levels. Serum MCP-1 may thus serve as a biomarker of 
      inflammation and disease progression in diabetes with periodontitis.
FAU - Radhakrishnan, Preethi
AU  - Radhakrishnan P
AD  - Department of Microbiology, Sri Ramachandra Medical College and Research 
      Institute, Sri Ramachandra University, Porur, Chennai, Tamil Nadu, India.
FAU - Srikanth, Padma
AU  - Srikanth P
AD  - Department of Microbiology, Sri Ramachandra Medical College and Research 
      Institute, Sri Ramachandra University, Porur, Chennai, Tamil Nadu, India.
FAU - Seshadri, Krishna G
AU  - Seshadri KG
AD  - Department of Endocrinology, Diabetes and Metabolism, Sri Ramachandra Medical 
      College and Research Institute, Sri Ramachandra University, Porur, Chennai, Tamil 
      Nadu, India.
FAU - Barani, Ramya
AU  - Barani R
AD  - Department of Microbiology, Sri Ramachandra Medical College and Research 
      Institute, Sri Ramachandra University, Porur, Chennai, Tamil Nadu, India.
FAU - Samanta, Maitreya
AU  - Samanta M
AD  - Environmental Health Engineering, Sri Ramachandra Medical College and Research 
      Institute, Sri Ramachandra University, Porur, Chennai, Tamil Nadu, India.
LA  - eng
PT  - Journal Article
PL  - India
TA  - Indian J Endocrinol Metab
JT  - Indian journal of endocrinology and metabolism
JID - 101555690
PMC - PMC4138906
OTO - NOTNLM
OT  - Glycemic control
OT  - periodontitis
OT  - serum Monocyte Chemoattractant Protein-1
COIS- Conflict of Interest: None declared
EDAT- 2014/08/22 06:00
MHDA- 2014/08/22 06:01
PMCR- 2014/07/01
CRDT- 2014/08/22 06:00
PHST- 2014/08/22 06:00 [entrez]
PHST- 2014/08/22 06:00 [pubmed]
PHST- 2014/08/22 06:01 [medline]
PHST- 2014/07/01 00:00 [pmc-release]
AID - IJEM-18-505 [pii]
AID - 10.4103/2230-8210.137498 [doi]
PST - ppublish
SO  - Indian J Endocrinol Metab. 2014 Jul;18(4):505-10. doi: 10.4103/2230-8210.137498.