PMID- 25144286
OWN - NLM
STAT- MEDLINE
DCOM- 20140930
LR  - 20140826
IS  - 0890-9091 (Print)
IS  - 0890-9091 (Linking)
VI  - 28
IP  - 7
DP  - 2014 Jul
TI  - Surgery for primary central nervous system lymphoma: is it time for reevaluation?
PG  - 632-7
LID - 200442 [pii]
AB  - The overall survival rate for primary central nervous system lymphoma (PCNSL) has 
      improved significantly. This prolongation in survival is related mainly to 
      advances in chemotherapy regimens and radiotherapy. In contrast, the role of 
      surgery in PCNSL has been limited because tumors are frequently not amenable to 
      resection and because most studies have failed to show that resection is 
      beneficial. A recent analysis of the German Primary CNS Lymphoma Study Group 1 
      (G-PCNSL-SG-1) trial has challenged this convention by showing that the survival 
      of patients with PCNSL may actually be prolonged if tumors are resected. While 
      there are a number of weaknesses in the analysis, many authorities now feel that 
      an attempt at gross total resection is reasonable for patients with solitary 
      lesions that can be removed without morbidity. However, even if resection does 
      benefit some patients, the diagnosis of lymphoma is almost always made in 
      retrospect, and there are few occasions when a neurosurgeon will actually need to 
      make a decision whether or not to resect a known PCNSL.
FAU - Bierman, Philip J
AU  - Bierman PJ
LA  - eng
PT  - Journal Article
PT  - Review
PL  - United States
TA  - Oncology (Williston Park)
JT  - Oncology (Williston Park, N.Y.)
JID - 8712059
SB  - IM
CIN - Oncology (Williston Park). 2014 Jul;28(7):637-8, 640, 642. PMID: 25144287
CIN - Oncology (Williston Park). 2014 Jul;28(7):641-2. PMID: 25144288
MH  - Central Nervous System Neoplasms/mortality/pathology/*surgery
MH  - Humans
MH  - Lymphoma/mortality/pathology/*surgery
MH  - *Neurosurgical Procedures/adverse effects
MH  - *Patient Selection
MH  - Risk Factors
MH  - Treatment Outcome
EDAT- 2014/08/22 06:00
MHDA- 2014/10/01 06:00
CRDT- 2014/08/22 06:00
PHST- 2014/08/22 06:00 [entrez]
PHST- 2014/08/22 06:00 [pubmed]
PHST- 2014/10/01 06:00 [medline]
AID - 200442 [pii]
PST - ppublish
SO  - Oncology (Williston Park). 2014 Jul;28(7):632-7.