PMID- 25145580
OWN - NLM
STAT- MEDLINE
DCOM- 20150519
LR  - 20211021
IS  - 1537-2995 (Electronic)
IS  - 0041-1132 (Linking)
VI  - 55
IP  - 3
DP  - 2015 Mar
TI  - Transfusion reactions in pediatric compared with adult patients: a look at rate, 
      reaction type, and associated products.
PG  - 563-70
LID - 10.1111/trf.12827 [doi]
AB  - BACKGROUND: The majority of reports on transfusion reactions address adult 
      patients. Less is known about the types, incidence, and other clinical details of 
      transfusion reactions in pediatric populations. Furthermore, to our knowledge, 
      there have been no previous reports directly comparing these aspects between 
      adults and pediatric patient populations to assess if there are differences. 
      STUDY DESIGN AND METHODS: Between the period of January 1, 2011, and February 1, 
      2013, all reported adult and pediatric transfusion reactions at Vanderbilt 
      University Medical Center (VUMC) were evaluated by transfusion medicine clinical 
      service. The information was subsequently shared with the hemovigilance database. 
      Data provided to hemovigilance included age, sex, blood product associated with 
      the reaction, severity of the reaction, and the type of transfusion reactions. 
      These were collated with hospital and blood bank information system-acquired data 
      on overall admission and product transfusion. RESULTS: A total of 133,671 
      transfusions were performed at VUMC during the study period including 20,179 
      platelet (PLT) transfusions, 31,605 plasma transfusions, 79,933 red blood cell 
      (RBC) transfusions, and 2154 cryoprecipitate transfusions. Over the same period, 
      108 pediatric and 277 adult transfusion reactions were recorded. This corresponds 
      to an incidence of 6.2 reactions per 1000 transfusions within the pediatric (age 
      < 21) population and an incidence of 2.4 reactions per 1000 transfusions within 
      the adult population. In both adult and pediatric populations, transfusion 
      reactions were most commonly associated with PLT, followed by RBC, and then 
      plasma transfusions. Within the pediatric population, subset analysis identified 
      multiple differences when compared to the adult population, including an 
      increased incidence of allergic transfusion reactions (2.7/1000 vs. 1.1/1000, p < 
      0.001), febrile nonhemolytic transfusion reactions (1.9/1000 vs. 0.47/1000, p < 
      0.001), and hypotensive transfusion reactions (0.29/1000 vs. 0.078/1000, p < 
      0.05). Interestingly, while the reaction incidence was the same between sexes in 
      adults, in pediatric patients, reactions were more common in male patients 
      (7.9/1000 pediatric males vs. 4.3/1000 pediatric females, p < 0.01). CONCLUSION: 
      To our knowledge this is the first study to provide detailed comparisons of acute 
      transfusion reactions to all blood products between pediatric and adult 
      populations at a single institution and supported by a single transfusion service 
      and culture. Collectively these data provide insight into pediatric transfusion 
      reactions and demonstrate a general increase in the incidence of transfusion 
      reactions within the pediatric compared to adult population.
CI  - (c) 2014 AABB.
FAU - Oakley, Fredrick D
AU  - Oakley FD
AD  - Department of Pathology, Microbiology and Immunology, Nashville, Tennessee.
FAU - Woods, Marcella
AU  - Woods M
FAU - Arnold, Shanna
AU  - Arnold S
FAU - Young, Pampee P
AU  - Young PP
LA  - eng
GR  - IK2 BX002498/BX/BLRD VA/United States
PT  - Comparative Study
PT  - Journal Article
DEP - 20140822
PL  - United States
TA  - Transfusion
JT  - Transfusion
JID - 0417360
RN  - 0 (cryoprecipitate coagulum)
RN  - 9001-27-8 (Factor VIII)
RN  - 9001-32-5 (Fibrinogen)
SB  - IM
CIN - Transfusion. 2015 Mar;55(3):466-7. PMID: 25759127
MH  - Acute Lung Injury/epidemiology/etiology
MH  - Adult
MH  - Age Distribution
MH  - Age of Onset
MH  - Blood Component Transfusion/adverse effects
MH  - Blood Group Incompatibility/epidemiology/etiology
MH  - Blood Safety
MH  - Child
MH  - Factor VIII/adverse effects
MH  - Female
MH  - Fibrinogen/adverse effects
MH  - Humans
MH  - Hypotension/epidemiology/etiology
MH  - Incidence
MH  - Male
MH  - Plasma
MH  - Prospective Studies
MH  - Sex Distribution
MH  - Shock/epidemiology/etiology
MH  - Tennessee/epidemiology
MH  - Transfusion Reaction/classification/*epidemiology/etiology
EDAT- 2014/08/26 06:00
MHDA- 2015/05/20 06:00
CRDT- 2014/08/23 06:00
PHST- 2014/04/25 00:00 [received]
PHST- 2014/07/14 00:00 [revised]
PHST- 2014/07/14 00:00 [accepted]
PHST- 2014/08/23 06:00 [entrez]
PHST- 2014/08/26 06:00 [pubmed]
PHST- 2015/05/20 06:00 [medline]
AID - 10.1111/trf.12827 [doi]
PST - ppublish
SO  - Transfusion. 2015 Mar;55(3):563-70. doi: 10.1111/trf.12827. Epub 2014 Aug 22.